Joplin, MO Mixed-use properties for sale

Versatile Commercial Building on Route 66

$1,798,500

15,000 SF

Versatile Commercial Building on Route 66

204 East 7Th St, Joplin, MO 64801

Adaptable commercial building in downtown Joplin with high visibility.

High‑visibility location off Main Street and Route 66 in downtown Joplin with strong traffic counts.
Approximately 15,000 square feet of space, allowing for current operations and future expansion.
Adaptable layout with multiple usable areas suitable for various business models (retail, office, service).
Existing professional insurance office space with quality finishes ready for immediate use.
Ample parking with approximately 41 spaces for staff, customers, and growth.

Updated: Jan 10

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$575,000

1,984 SF

Unique Cigar Lounge on Route 66

1209 W 7Th St, Joplin, MO 64801

Cigar lounge with humidor, patio, and Route 66 location.

Established cigar lounge business with memberships included in sale.
Prime location on historic Route 66, attracting locals and tourists.
Large walk‑in humidor with significant inventory and selection.
Unique vintage charm with antique furniture and decor.
Outdoor patio seating for social gatherings.

Updated: Dec 31, 2025

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$3,900,000

23,470 SF

Restored Mixed-Use Building in Joplin

Historic building with residential and commercial units in downtown Joplin.

223 W 3Rd St, Joplin, MO 64801

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Pending

$4,100,000

43,053 SF

Prime Commercial Property on Main

4.14-acre commercial property with showroom, apartment, and high visibility.

5014 S Main St, Joplin, MO 64804

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$1,150,000

5,200 SF

Versatile Live-Work Property in Joplin

4,000 sq ft shop with 1,200 sq ft living space.

4445 E Cypress Rd, Joplin, MO 64801

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$990,000

11,081 SF

Historic Route 66 Mixed-Use Property

Mixed-use property with retail/office space and luxury loft residence.

524 S Main St, Joplin, MO 64801

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$225,000

1,984 SF

Route 66 Commercial Property

Unique commercial space with live-work potential on historic Route 66.

1209 W 7Th St, Joplin, MO 64801

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$299,000

5,700 SF

Historic Mixed-Use Building, Joplin

Prime downtown location with retail, commercial, and residential potential.

405 S Main St, Joplin, MO 64801

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Unique Redevelopment Opportunity in Joplin

$2,750,000

52,000 SF

Unique Redevelopment Opportunity in Joplin

52,000 sq ft property with redevelopment potential in Joplin, MO.

510 S Wall Ave, Joplin, MO 64801

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$200,000

15,000 SF

Historic Mixed-Use Property in Joplin

15,000 sq ft historic property in Joplin's Historic District.

830 Main St, Joplin, MO 64801

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$2,200,000

17,940 SF

Downtown Joplin Mixed-Use Property

Premier mixed-use property with luxury apartments and commercial spaces.

702 S Wall Ave, Joplin, MO 64801

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$850,000

42,907 SF

Versatile Mixed-Use Commercial Property

42,907 SF mixed-use property with office and warehouse space.

902 E 4Th St, Joplin, MO 64801

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$2,600,000

30,200 SF

Joplin Retail & Warehouse Opportunity

High-Visibility Commercial Property, Missouri

2920 Range Line Rd, Joplin, MO 64804

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Joplin Union Depot: Redevelopment Opportunity

Contact for pricing

22,640 SF

Joplin Union Depot: Redevelopment Opportunity

Historic Train Station, 22,640 sq ft

205 Main St, Joplin, MO 64801

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$2,200,000

32,750 SF

Joplin Warehouse/Office Space

32,750 SF Mixed-Use Property, Vacant

5571 Main Street Rd, Joplin, MO 64801

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$1,800,000

20,185 SF

WestPointe Centre: Joplin Investment

Thriving Mixed-Use Property on Route 66

2207 7Th St, Joplin, MO 64801

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$3,525,000

30,000 SF

Joplin MO Industrial Flex Space

30,000 SF Multi-Tenant Office/Warehouse

4830 32Nd St, Joplin, MO 64804

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Explore Off-Market Properties in Joplin, MO

Consider similar Off-Market properties in Joplin, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

5571 Main Street Rd

Individual retail properties • 32,750 SF

Value Estimation by Request

5571 Main Street Rd, Joplin, MO 64801

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3502 Red Iron Dr

Distribution properties • 7,700 SF

Value Estimation by Request

3502 Red Iron Dr, Joplin, MO 64801

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810 Maiden Ln

Restaurants • 9.82 Acres

Value Estimation by Request

810 Maiden Ln, Joplin, MO 64801

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2207 7Th St

Mixed-use properties • 20,185 SF

Value Estimation by Request

2207 7Th St, Joplin, MO 64801

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4531 Range Line Rd

Distribution properties • 5,000 SF

Value Estimation by Request

4531 Range Line Rd, Joplin, MO 64804

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5734 Main St

Churches & religious facilities • 4,615 SF

Value Estimation by Request

5734 Main St, Joplin, MO 64804

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Joplin, MO 64804

OFFICE/RESIDENTIAL (MIXED USE) • 1,208 SF

Value Estimation by Request

Joplin, MO 64804

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Joplin, MO Mixed-Use Properties Investment Opportunities Market Analysis

Explore 67 mixed-use properties for sale in Joplin, MO, showcased through 17 active listings on our real estate platform. These investment opportunities span a total of 21,783,922 square feet of properties for sale, with an estimated market value of $28,599,000.

Prices for multi use buildings in Joplin, MO start at $155,000, averaging $583,653, and reaching up to $4,100,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

Joplin, MO Mixed-use Properties for Sale

Versatile Commercial Building on Route 66

Adaptable commercial building in downtown Joplin with high visibility.

Unique Cigar Lounge on Route 66

Cigar lounge with humidor, patio, and Route 66 location.

Restored Mixed-Use Building in Joplin

Prime Commercial Property on Main

Versatile Live-Work Property in Joplin

Historic Route 66 Mixed-Use Property

Route 66 Commercial Property

Historic Mixed-Use Building, Joplin

Unique Redevelopment Opportunity in Joplin

Historic Mixed-Use Property in Joplin

Downtown Joplin Mixed-Use Property

Versatile Mixed-Use Commercial Property

Joplin Retail & Warehouse Opportunity

Joplin Union Depot: Redevelopment Opportunity

Joplin Warehouse/Office Space

WestPointe Centre: Joplin Investment

Joplin MO Industrial Flex Space

Explore Off-Market Properties in Joplin, MO

5571 Main Street Rd

3502 Red Iron Dr

810 Maiden Ln

2207 7Th St

4531 Range Line Rd

5734 Main St

Joplin, MO 64804

Joplin, MO Mixed-Use Properties Investment Opportunities Market Analysis

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Joplin, MO Mixed-use Properties for Sale

Versatile Commercial Building on Route 66

Adaptable commercial building in downtown Joplin with high visibility.

Unique Cigar Lounge on Route 66

Cigar lounge with humidor, patio, and Route 66 location.

Restored Mixed-Use Building in Joplin

Prime Commercial Property on Main

Versatile Live-Work Property in Joplin

Historic Route 66 Mixed-Use Property

Route 66 Commercial Property

Historic Mixed-Use Building, Joplin

Unique Redevelopment Opportunity in Joplin

Historic Mixed-Use Property in Joplin

Downtown Joplin Mixed-Use Property

Versatile Mixed-Use Commercial Property

Joplin Retail & Warehouse Opportunity

Joplin Union Depot: Redevelopment Opportunity

Joplin Warehouse/Office Space

WestPointe Centre: Joplin Investment

Joplin MO Industrial Flex Space

Explore Off-Market Properties in Joplin, MO

5571 Main Street Rd

3502 Red Iron Dr

810 Maiden Ln

2207 7Th St

4531 Range Line Rd

5734 Main St

Joplin, MO 64804

Joplin, MO Mixed-Use Properties Investment Opportunities Market Analysis

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Most Searched ZIP Codes in Joplin, MO

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