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    Rio Grande City, TX Medical Office Space for Sale

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    Rio Grande City Commercial Property
    $825,000
    8,300 SF

    Rio Grande City Commercial Property

    5448 E Us Highway 83, Rio Grande City, TX 78582

    8300 square foot commercial building suitable for medical, retail.

    • Prime location directly off US Highway 83.
    • Total of 8300 square feet of office space.
    • Four separate office spaces suitable for medical, retail, or other uses.
    • Located in Santa Cruz Medical Plaza.
    • Covered and special needs parking available.
    Updated: Dec 29, 2025
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    Medical Plaza Investment Opportunity
    $2,200,000

    Medical Plaza Investment Opportunity

    5322 E Us Highway 83, Rio Grande City, TX 78582

    Medical plaza for sale in Rio Grande City, Texas.

    • Dedicated medical plaza ideal for healthcare businesses.
    • Approximately 15,750 SF of space, suitable for various medical or office uses.
    • Sits on 1.11 acres, potentially allowing for expansion.
    • Strategic location in Rio Grande City.
    • Located in a high‑traffic area near Payne Dealership, City Offices, Holiday Inn Express, Exxon Mobil, Family Dollar Store & Tejano Mart.
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    Medical Plaza Investment Opportunity
    $2,200,000
    17,152 SF

    Medical Plaza Investment Opportunity

    Medical plaza for sale in Rio Grande City, Texas.

    5322 E Us Highway 83, Rio Grande City, TX 78582
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    Mixed-Use Property in Rio Grande
    Contact for pricing
    3,752 SF

    Mixed-Use Property in Rio Grande

    Two buildings suitable for office and retail in Rio Grande.

    115 N Britton Ave, Rio Grande City, TX 78582
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    Based on your search, we've compiled 8 Potential Opportunities for your consideration. Besides 4 Active listings in Rio Grande City, TX, we suggest exploring several alternatives: 4 properties in Nearby Cities

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    La Joya Commercial Space
    $359,000
    2,912 SF

    La Joya Commercial Space

    Prime commercial space off U.S. Highway 83 in La Joya.

    844 E Us Highway 83, La Joya, TX 78560
    View details
    La Joya Commercial Building
    $299,998
    2,912 SF

    La Joya Commercial Building

    2,912 SF commercial building in front of IDEA school.

    844 E Us Highway 83, La Joya, TX 78560
    View details
    Mission, TX Commercial Land
    $445,000
    3.95 Acres

    Mission, TX Commercial Land

    High-traffic location suitable for commercial or multifamily development.

    2210 W 5 Mile Line Rd, Mission, TX 78574
    View details
    Commercial Lot in Alton, Texas
    $395,000
    0.71 Acres

    Commercial Lot in Alton, Texas

    Prime commercial lot suitable for various business uses.

    1425 W Main Ave, Mission, TX 78573
    View details

    Rio Grande City, TX Medical Office Space Investment Opportunities Market Analysis

    Explore 4 medical office space for sale in Rio Grande City, TX, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 34,935 square feet of properties for sale, with an estimated market value of $825,000.

    Sale prices for medical spaces in Rio Grande City, TX start at $825,000, averaging $825,000, and reaching up to $825,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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