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Columbiana, AL

Medical Premises

Columbiana, AL Medical Office Space for Sale

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Birmingham, AL Chelsea, AL Calera, AL Wilsonville, AL Shelby, AL Alabaster, AL Pelham, AL Sylacauga, AL

Adaptable Office/Medical Building on Highway

Updated: Nov 22, 2025

Adaptable Office/Medical Building on Highway

22727 Alabama 25, Columbiana, AL 35051

Contact for pricing

3,889 sqft

High‑visibility location on Highway 25 with prominent signage opportunities.
Adaptable 4,000± SF building suitable for medical or professional office use.
Large 1.55± acre site with ample surface parking and easy site circulation.
Flexible layout with multiple private rooms ideal for exam rooms, offices, or consult rooms.
Single‑tenant configuration ideal for owner‑occupant.

Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center

Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 1 Active listings in Columbiana, AL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 7 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Medical Office Space For Sale

Medical Office Space For Sale

3055 Lorna Road, Hoover, AL 35216

$1,350,000

2,400 sqft

Located in Hoover near I-65 and Hwy. 31.

Alabaster Medical Mile Opportunity

Alabaster Medical Mile Opportunity

223 1st N Street, Alabaster, AL 35007

$475,000

3,290 sqft

Prime location in Alabaster's Medical Mile District.

Medical Office Building For Sale

Medical Office Building For Sale

300 1st Street North |, Alabaster, AL 35007

$1,575,000

3.50 AC lot

100% occupied medical office building near Shelby Baptist Medical Center.

Freestanding Medical Office Building

Freestanding Medical Office Building

1575 Montgomery Highway, Hoover, AL 35216

Contact for pricing

6,218 sqft 0.94 AC lot

Freestanding medical/office building formerly an urgent care facility with 32 parking spaces and frontage on Montgomery Hwy.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Lot on Corner Location

Commercial Lot on Corner Location

747 Memorial Drive, Bessemer, AL 35022

$104,900

0.76 AC lot

Corner 0.76-acre commercial lot near UAB West Hospital.

Highway Frontage Investment Property

Highway Frontage Investment Property

2400 Highway 14, Millbrook, AL 36054

$3,980,250

17.69 AC lot

Investment property with highway frontage in a fast-growing corridor.

Highway 14 Investment Opportunity

Highway 14 Investment Opportunity

2400 Highway 14, Millbrook, AL 36054

$3,980,250

770,576 sqft

Commercial land with highway frontage near I-65 in Millbrook, AL.

Commercial Land in Pike Road

Commercial Land in Pike Road

12645 Highway 80, Pike Road, AL 36064

$4,207,025

Commercial land available in high-traffic Pike Road location.

Off-Market Properties in Columbiana, AL

Consider similar Off-Market properties in Columbiana, AL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

108 Mildred St

MEDICAL BUILDING

108 Mildred St, Columbiana, AL 35051-9381

Value Estimation by Request

1,487 sqft 0.26 AC lot

112 Main St

MEDICAL BUILDING

112 Main St, Columbiana, AL 35051-5395

Value Estimation by Request

3,051 sqft 0.17 AC lot

247 Walton St

MEDICAL BUILDING

247 Walton St, Columbiana, AL 35051-9701

$815,000

Estimated value

5,881 sqft 0.87 AC lot

22266 Hwy 25

MEDICAL BUILDING

22266 Hwy 25, Columbiana, AL 35051-8618

$1,800,000

Estimated value

14,327 sqft 3.62 AC lot

Columbiana, AL 35051

MEDICAL BUILDING

Columbiana, AL 35051

Value Estimation by Request

3,889 sqft 1.55 AC lot

21591 Hwy 25

MEDICAL BUILDING

21591 Hwy 25, Columbiana, AL 35051-8607

$590,000

Estimated value

3,530 sqft 1.04 AC lot

201 Hwy 25th E

MEDICAL BUILDING

201 Hwy 25th E, Columbiana, AL 35051-9373

$530,000

Estimated value

3,360 sqft 0.58 AC lot

Columbiana, AL Medical Office Space Market Trends and Statistics

Explore 8 medical office space for sale in Columbiana, AL on our real estate platform. These investment opportunities span a total of 3,889 square feet of properties for sale.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 10K

Population Growth (5Y) +12.2%

Median Household Income $73,682

College Educated 27.4%

High-Yield Neighborhoods for Investment

Identify Columbiana submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
35051	$1.2M

Taxes & Financing

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Shelby County

New Delisted

Total CRE Inventory on Market (SF)

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