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    Highland, IL Medical Office Space for Lease

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    Highland Retail/Office/Medical Spaces For Lease
    $14 SF/Yr
    1,775 SF

    Highland Retail/Office/Medical Spaces For Lease

    12603 State Rte 143, Highland, IL 62249

    Office, retail, and medical spaces available for lease in Highland.

    • Located on IL‑143 with nearly 10,000 ADT.
    • Situated at a Lighted Intersection.
    • In front of R.P. Lumber.
    • Suite 8: 2,604 SF – Office/Medical space with Waiting Area, Reception Area, Private Therapy Room, 3 Treatment Bays, Open Therapy Area, Private Office, Storage Room and Restroom.
    • Suite 6: 1,775 SF – Retail/Office space with Open Work Area, Supply Room, Private Office, Showroom, Restroom.
    Updated: Sep 22, 2025
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    Remodeled Medical Office Suite
    $10 SF/Yr
    3,040 SF

    Remodeled Medical Office Suite

    1628-1336 Mercantile Dr, Highland, IL

    3,040 SF remodeled medical office suite for lease.

    • Newly remodeled 3,040 SF medical office suite.
    • Features a staff lounge with kitchenette, waiting room with reception desk, (7) exam rooms, (1) lab/documentation area, and restrooms.
    • Strategically situated in Highland, IL, just off Highway 40 for easy access.
    • Proximity to St. Louis, MO (30 miles).
    • Well‑appointed space ideal for efficient and versatile office operations.
    Updated: Sep 19, 2023
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    Remodeled Medical Office Suite
    Contact for pricing
    3,040 SF

    Remodeled Medical Office Suite

    Newly remodeled medical office suite in Woodcrest Plaza, Highland, IL.

    1336 Mercantile Dr, Highland, IL 62249
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    Based on your search, we've compiled 13 Potential Opportunities for your consideration. Besides 3 Active listings in Highland, IL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

    Explore Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Professional Office Suite For Lease
    $14 SF/Yr
    3,200 SF

    Professional Office Suite For Lease

    3,200 SF office suite suitable for medical or professional use.

    4 Park Pl, Swansea, IL
    View details
    Collinsville Office Space for Lease
    $16 SF/Yr
    13,003 SF

    Collinsville Office Space for Lease

    13,000+ SF office space available in Collinsville's Eastport District.

    1616 Eastport Plaza Dr, Collinsville, IL
    View details
    Turnkey Medical Office For Lease
    $13 SF/Yr
    3,600 SF

    Turnkey Medical Office For Lease

    3,600 SF medical office with easy highway access.

    101 United Dr, Collinsville, IL
    View details
    Medical/Office Building with Walkout Basement
    Contact for pricing
    3,000 SF

    Medical/Office Building with Walkout Basement

    3,000 SF medical/office building with finished walkout basement.

    3214 N Illinois St, Swansea, IL 62226
    View details

    Explore Similar Spaces for Sale in Highland, IL

    Consider Similar Space for Sale. We found 2 Spaces matching your search parameters.

    Versatile Medical/Athletic Facility For Sale
    $449,000
    5,375 SF

    Versatile Medical/Athletic Facility For Sale

    5,375 SF building suitable for medical, athletic, or office use.

    1117 Washington St, Highland, IL
    View details
    New Office Space Available
    Contact for pricing
    1,855 SF

    New Office Space Available

    Newly constructed office space near St. Joseph's Hospital.

    5-25 Apex Dr, Highland, IL
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Highway 72 Corner Lot
    $6,500 /Mo
    1,875 SF

    Highway 72 Corner Lot

    1.6 acre commercial lot for rent on Highway 72.

    30472 Highway 72, Madison, AL 35756
    View details
    Prime Land in Upper St Clair
    $50,000

    Prime Land in Upper St Clair

    Commercial land for lease in Upper St Clair, PA.

    2585 Maple Lane, Upper St Clair, PA 15241
    View details
    Prime Commercial Lot For Rent
    $7,500 /Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
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    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    0 Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
    View details

    Highland, IL Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Highland, IL with 3 listings featured on our commercial real estate exchange. The current inventory includes 195,584,400 square feet of properties with an estimated lease value of $24 SF/Yr.

    Estimated lease rates for Medical Office Space in Highland, IL begin at $10 SF/Yr, with an average of $12 SF/Yr and extend to $14 SF/Yr.
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    Browse Medical Office Space for Lease Near Highland, IL

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    Most Searched ZIP Codes in Highland, IL

    • 62249

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