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    Sussex County, DE Medical Office Space for Lease

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    Newark, DE New Castle, DE Dover, DE
    9 results
    Versatile Lewes Office Space
    $23 SF/Yr

    Versatile Lewes Office Space

    16529 N COASTAL Highway, Lewes, DE 19958

    Professional office space ideal for medical or executive use.

    • Versatile layout ideal for medical, executive, or professional office use, featuring multiple private offices/exam rooms and flexible workspaces.
    • Excellent front‑facing visibility and convenient client access.
    • Strategically positioned near major healthcare destinations.
    • Opportunity to customize the layout based on operational needs.
    • Two potential reception areas at the main front entrance and a large lobby.
    Updated: Feb 23
    View details
    Retail Space in Seaford Redevelopment
    $16 SF/Yr

    Retail Space in Seaford Redevelopment

    1000 W STEIN Highway, Seaford, DE 19973

    Front-facing suite in mixed-use redevelopment with high visibility.

    • Front‑facing suite with direct exposure to Stein Highway, offering strong daily traffic and excellent visibility.
    • Located in The Nylon Capital Center, a Class A mixed‑use redevelopment totaling over 218,000 SF.
    • Anchor tenants include TidalHealth, Delaware Technical Community College, Dollar Tree, Community Bank, and The Mill.
    • Ideal for retail, medical, or service‑oriented businesses.
    • Ample parking and multiple access points.
    Updated: Nov 7, 2025
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    Prime Retail/Medical Space Available
    $18 SF/Yr

    Prime Retail/Medical Space Available

    Freestanding building in Seaford's transformative mixed-use redevelopment.

    900 W STEIN Highway, Seaford, DE 19973
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    Seaford, DE Commercial Space For Lease
    $1,500 /Mo

    Seaford, DE Commercial Space For Lease

    Move-in ready commercial space ideal for medical or healthcare businesses.

    808 MIDDLEFORD Road, Seaford, DE 19973
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    Medical Office Space on Route 1
    $24 SF/Yr
    1,500 SF

    Medical Office Space on Route 1

    Medical office spaces available in Milford, DE, on Route 1.

    100 Silicato Pkwy, Milford, DE 19963
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    Seaford, DE Medical Office Space
    $1,500 /Mo

    Seaford, DE Medical Office Space

    Move-in ready office space near Tidal Health Nanticoke hospital.

    808 MIDDLEFORD Road, Seaford, DE 19973
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    Seaford, DE Commercial Condo Suite
    $12 SF/Yr

    Seaford, DE Commercial Condo Suite

    Commercial condo suite in Seaford with multiple exam and private offices.

    543 N SHIPLEY Street, Seaford, DE 19973
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    Medical/Office Space Available for Rent
    $24 SF/Yr
    1,350 SF

    Medical/Office Space Available for Rent

    1350 SF medical/office space available for rent.

    100 Silicato Pkwy, Milford, DE
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    Lewes Georgetown Hwy Leasing Opportunity
    Contact for pricing
    7,500 SF

    Lewes Georgetown Hwy Leasing Opportunity

    Premier commercial property with high visibility and multiple unit sizes.

    26866 Lewes Georgetown Hwy, Harbeson, DE 19951
    View details
    Based on your search, we've compiled 23 Potential Opportunities for your consideration. Besides 9 Active listings in Sussex County, DE, we suggest exploring alternatives. Similar 10 Properties for Sales.

    Explore Similar Spaces for Sale in Sussex County, DE

    Consider Similar Space for Sale. We found 10 Spaces matching your search parameters.

    Seaford Office Building For Sale
    $780,000
    0.51 Acres

    Seaford Office Building For Sale

    Professional office building in prime location with expansion potential.

    924 MIDDLEFORD Road, Seaford, DE 19973
    View details
    Commercial Property on Major Highway
    $1,250,000
    4,200 SF

    Commercial Property on Major Highway

    C-1 zoned commercial property on 2 acres for sale.

    8991 REDDEN ROAD, Bridgeville, DE 19933
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    Milton Medical Park Investment Opportunity
    $3,975,000
    12,860 SF

    Milton Medical Park Investment Opportunity

    Fully leased medical office park with expansion potential in Milton, DE.

    611 Federal Street, Milton, DE 19968
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    Freestanding Building in Seaford Redevelopment
    Contact for pricing
    12,738 SF

    Freestanding Building in Seaford Redevelopment

    Highly visible 12,738 SF building in mixed-use redevelopment.

    900 West Stein Highway, Seaford, DE 19973
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    Freestanding Building in Mixed-Use Development
    Contact for pricing
    12,738 SF

    Freestanding Building in Mixed-Use Development

    12,738 SF building suitable for retail, medical, or institutional use.

    900 West Stein Highway, Seaford, DE 19973
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    Medical Office Investment Opportunity
    $1,250,000
    4,800 SF

    Medical Office Investment Opportunity

    4,800 SF Medical office Building occupied by a nationally recognized tenant.

    800 HEALTH SERVICES DRIVE, Seaford, DE 19973
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    Seaford Medical Office Space For Sale
    $275,000

    Seaford Medical Office Space For Sale

    Class A medical office space in professional park, Seaford, DE.

    1350 Middleford Road Suite 502, Seaford, DE 19973
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    Milton Medical Park Investment Opportunity
    $3,975,000
    12,860 SF

    Milton Medical Park Investment Opportunity

    Fully leased medical office park with expansion potential in Milton, DE.

    611 Federal Street, Milton, DE 19968
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    Professional Office Near TidalHealth Campus
    $299,000
    2,011 SF

    Professional Office Near TidalHealth Campus

    Commercial investment property with long-term tenant, Chesapeake Bay Orthopedics.

    1340 Middleford Road #403, Seaford, DE 19973
    View details
    Medical Office Investment Opportunity
    $1,250,000
    4,800 SF

    Medical Office Investment Opportunity

    4,800 SF Medical office Building occupied by nationally recognized tenant.

    800 Health Services Dr, Seaford, DE 19973
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Lot For Rent
    $7,500 /Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
    View details
    Highway 72 Corner Lot
    $6,500 /Mo
    1,875 SF

    Highway 72 Corner Lot

    1.6 acre commercial lot for rent on Highway 72.

    30472 Highway 72, Madison, AL 35756
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    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    0 Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
    View details
    Winter Park Mixed-Use Opportunity
    $8,500 /Mo
    23,056 SF

    Winter Park Mixed-Use Opportunity

    Double commercial lot in Winter Park, FL, for lease.

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792
    View details

    Sussex County, DE Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Sussex County, DE with 9 listings featured on our commercial real estate exchange. The current inventory includes 4,275,701,394 square feet of properties with an estimated lease value of $48 SF/Yr.

    Estimated lease rates for Medical Office Space in Sussex County, DE begin at $0.72 SF/Yr, with an average of $12 SF/Yr and extend to $24 SF/Yr.
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    Browse Medical Office Space for Lease Near Sussex, DE

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