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    Lewes, DE Medical Office Space for Lease

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    Versatile Lewes Office Space
    $23 SF/Yr

    Versatile Lewes Office Space

    16529 N COASTAL Highway, Lewes, DE 19958

    Professional office space ideal for medical or executive use.

    • Versatile layout ideal for medical, executive, or professional office use, featuring multiple private offices/exam rooms and flexible workspaces.
    • Excellent front‑facing visibility and convenient client access.
    • Strategically positioned near major healthcare destinations.
    • Opportunity to customize the layout based on operational needs.
    • Two potential reception areas at the main front entrance and a large lobby.
    Updated: Feb 23
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    Based on your search, we've compiled 9 Potential Opportunities for your consideration. Besides 1 Active listings in Lewes, DE, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

    Explore Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Seaford, DE Commercial Space For Lease
    $1,500 /Mo

    Seaford, DE Commercial Space For Lease

    Move-in ready commercial space ideal for medical or healthcare businesses.

    808 MIDDLEFORD Road unit: 6, Seaford, DE 19973
    View details
    Medical Office Space on Route 1
    $24 SF/Yr
    1,500 SF

    Medical Office Space on Route 1

    Medical office spaces available in Milford, DE, on Route 1.

    100 Silicato Pkwy, Milford, DE 19963
    View details
    Seaford, DE Medical Office Space
    $1,500 /Mo

    Seaford, DE Medical Office Space

    Move-in ready office space near Tidal Health Nanticoke hospital.

    808 MIDDLEFORD Road unit: 4, Seaford, DE 19973
    View details
    Medical/Office Space Available for Rent
    $24 SF/Yr
    1,350 SF

    Medical/Office Space Available for Rent

    1350 SF medical/office space available for rent.

    100 Silicato Pkwy, Milford, DE
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Coastal Highway Commercial Opportunity
    Contact for pricing

    Coastal Highway Commercial Opportunity

    Prime commercial parcel on Coastal Highway, available February 2026.

    18355 Coastal Hwy, Lewes, DE 19958
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    Millsboro Commercial Lot for Rent
    $800 /Mo

    Millsboro Commercial Lot for Rent

    0.78 AC commercial lot with C-1 zoning in Millsboro.

    Kerlyn Dr, Millsboro, DE
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    Millsboro Land for Lease
    Contact for pricing

    Millsboro Land for Lease

    Approximately 3.70 acres available for ground lease or joint venture.

    235 Mitchell St, Millsboro, DE 19966
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    Prime Retail/Dining Pad Site
    $42 SF/Yr

    Prime Retail/Dining Pad Site

    1.0 acre pad site available for lease.

    995 N Dupont Blvd, Milford, DE
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    Lewes, DE Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Lewes, DE with 1 listings featured on our commercial real estate exchange. The current inventory includes 2,030,296,718 square feet of properties with an estimated lease value of $23 SF/Yr.

    Estimated lease rates for Medical Office Space in Lewes, DE begin at $23 SF/Yr, with an average of $23 SF/Yr and extend to $23 SF/Yr.
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