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    Port St Lucie, FL Commercial Real Estate for Lease

    51 results
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    Freestanding Building on US Highway
    $26 SF/Yr
    46,609 SF

    Freestanding Building on US Highway

    10244 S Us Highway 1, Port St Lucie, FL 34952

    General Commercial zoning ideal for retail, medical, or restaurant.

    • High‑traffic location on US Hwy 1 with 35,500 AADT and 187' frontage.
    • General Commercial zoning suitable for retail, medical, restaurant, or professional use.
    • Ideal sub‑lease option with two separate entrances.
    • Existing electronic and media infrastructure wiring throughout.
    • Modular interior wall system allows for easy reconfiguration.
    Updated: Nov 16, 2025
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    Medical Office Space For Rent
    $24 SF/Yr
    998 SF

    Medical Office Space For Rent

    1801 SE Hillmoor Dr, Port St Lucie, FL 34952

    Updated medical office space available for rent in Port St. Lucie.

    • Updated with new vinyl plank flooring, paint, and cabinetry.
    • Features 3 exam rooms and 1 lab/kitchen.
    • Includes 2 bathrooms and 2 business offices.
    • Equipped with central heating and air conditioning.
    • Built in 1996 with block and concrete construction.
    Updated: Aug 31, 2025
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    Freestanding Building on US Highway
    $26 SF/Yr

    Freestanding Building on US Highway

    Versatile commercial space ideal for retail, medical, or restaurant use.

    10244 S Us Highway 1, Port St Lucie, FL 34952
    View details
    Port St. Lucie Executive Office
    $1,527 / Mo
    998 SF

    Port St. Lucie Executive Office

    Executive office suite in Port St. Lucie medical corridor.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Professional Office Space Available
    $27,444

    Professional Office Space Available

    Class A office space in professional center for lease.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Professional Office Space Available
    $2,287 / Mo
    998 SF

    Professional Office Space Available

    Class A office suite with private offices and open space.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Tradition Village Square Office Space
    $27 SF/Yr
    28,959 SF

    Tradition Village Square Office Space

    Office space for lease in vibrant Tradition community.

    10801 SW Tradition Sq, Port St Lucie, FL 34987
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    Port St. Lucie Retail Center
    $23 SF/Yr

    Port St. Lucie Retail Center

    Retail strip center with high-traffic exposure on US-1 Highway.

    7630 S Us Highway 1, Port St Lucie, FL 34952
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    Visible Corner Office Space Available
    $24 SF/Yr
    3,900 SF

    Visible Corner Office Space Available

    Office space with high visibility and convenient access.

    481 Southwest Port St Lucie Blvd, Port St Lucie, FL 34953
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    Open Bay Warehouse For Rent
    $1,331 / Mo

    Open Bay Warehouse For Rent

    940 SF warehouse with office and loft space available.

    1576 South Niemeyer Cir, Port St Lucie, FL 34952
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    Retail Space on Village Parkway
    Contact for pricing
    11,504 SF

    Retail Space on Village Parkway

    Versatile retail spaces in rapidly growing Port St. Lucie.

    10704 Southwest Village Pkwy, Port St Lucie, FL 34987
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    St. Lucie West Office Building
    $35 SF/Yr
    18,000 SF

    St. Lucie West Office Building

    Office building in a high-growth area with excellent visibility.

    9265 Commerce Centre Dr, Port St Lucie, FL 34986
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    Port St. Lucie Flex Warehouse
    $20 SF/Yr
    26,880 SF

    Port St. Lucie Flex Warehouse

    Flex warehouse buildings with office space and roll-up doors.

    532-534 Northwest Mercantile Pl, Port St Lucie, FL 34986
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    Medical Office Space on US-1
    $18 SF/Yr
    5,473 SF

    Medical Office Space on US-1

    Newly renovated medical space with high visibility and convenient access.

    7664 South Us Highway 1 U.S, Port St Lucie, FL 34952
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    Port St. Lucie Flex Space
    $20 SF/Yr
    22,500 SF

    Port St. Lucie Flex Space

    5,000 SF flex space available for lease.

    603-619 NW Mercantile Pl, Port St Lucie, FL 34986
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    Tradition Commercial Land Lease Opportunity
    $95,000
    7 SF

    Tradition Commercial Land Lease Opportunity

    Prime commercial land available for lease in a growing area.

    Crosstown Pkwy, Port St Lucie, FL 34987
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    Port St. Lucie Flex Space
    $1,600 / Mo
    7,030 SF

    Port St. Lucie Flex Space

    Small bay industrial flex building with convenient highway access.

    1726 Southwest Biltmore St, Port St Lucie, FL 34984
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    Outparcels Available For Lease
    Contact for pricing

    Outparcels Available For Lease

    Outparcel opportunities in Lowe’s anchored shopping center.

    SW Village Pkwy, Port St Lucie, FL 34953
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    Prime Retail Outparcel on US-1
    Contact for pricing
    2 SF

    Prime Retail Outparcel on US-1

    High-visibility land for lease, ground lease, or build-to-suit.

    10400 South Us Highway 1 U.S, Port St Lucie, FL 34952
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    Retail Space in St Lucie
    Contact for pricing
    4,529 SF

    Retail Space in St Lucie

    Retail space available in a busy shopping center.

    1315-1367 St Lucie Blvd W, Port St Lucie, FL
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    Land Available Near Future Residences
    Contact for pricing

    Land Available Near Future Residences

    3.76 acres available near future residential development.

    Crosstown Pkwy, Port St Lucie, FL 34987
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    Retail Unit in PSL Centre
    Contact for pricing
    950 SF

    Retail Unit in PSL Centre

    950 SF commercial unit with US 1 visibility.

    8479-8521 S Us Highway 1, Port St Lucie, FL 34952
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    29 Acre Development Site
    Contact for pricing

    29 Acre Development Site

    29 acre commercial development site at Florida Turnpike and Port.St.Lucie.Blvd

    Nwc Of Prt St Lucie Blvd & Fl Tpke, Port St Lucie, FL 34953
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    Medical Office Space on Lake
    Contact for pricing
    3,915 SF

    Medical Office Space on Lake

    Single-story medical office with lake views and recent upgrades.

    573 NW Lake Whitney Pl, Port St Lucie, FL 34986
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    Port St Lucie, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Port St Lucie, FL with 51 listings featured on our commercial real estate exchange. The current inventory includes 8,094,527,033 square feet of properties with an estimated lease value of $454 /Mo.

    Estimated lease rates for Commercial real estate in Port St Lucie, FL begin at $2 SF/Yr, with an average of $25 SF/Yr and extend to $40 SF/Yr.
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