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    Florence, SC Commercial Real Estate for Sale

    150 results
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    Industrial Building in Florence, SC
    $550,000
    67,518 SF

    Industrial Building in Florence, SC

    121 Lawson St, Florence, SC 29501

    Standalone industrial building suitable for various commercial and industrial uses.

    • Standalone industrial building with approximately 5,000 SF interior space plus 2,000 SF of covered area.
    • Light Industrial zoning supports a wide range of commercial and industrial uses.
    • Suitable for fabrication, automotive uses, contractor operations, or storage.
    • Includes interior office space.
    • Features include delivery door, lifts, loading dock, security system, 220/440 volts, and drive‑in door.
    Updated: Mar 3
    View details
    Historic Downtown Florence Commercial Building
    $2,700,000
    16,304 SF

    Historic Downtown Florence Commercial Building

    248-260 W Evans St, Florence, SC 29501

    16,000 SF historic building in thriving downtown Florence.

    • Prime downtown Florence location in a thriving area.
    • Large 16,000 sq ft historic building with limitless potential.
    • Significant parking available (over 100 spaces), rare for downtown.
    • Versatile space currently configured with multiple tenants (Law Firm, H&R Block, Hair Studio).
    • Spacious 1.47‑acre lot allows for growth and development.
    Updated: Mar 9
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    Industrial Buildings with Power & Access
    $199,000
    40,000 SF

    Industrial Buildings with Power & Access

    Two industrial buildings ideal for fabrication, automotive, or storage.

    120 N Guerry St, Florence, SC 29501
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    Established Auto Body Business For Sale
    $1,305,000
    4,125 SF

    Established Auto Body Business For Sale

    Turn-key auto body business with equipment, client roster, and real estate.

    803 Ranch Rd, Florence, SC 29506
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    Florence Commercial Land For Sale
    $396,396
    0.91 Acres

    Florence Commercial Land For Sale

    0.91 acre commercial land parcel in Florence, South Carolina.

    Presbyterian Rd, Florence, SC 29501
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    Florence Commercial Land For Sale
    $792,792
    1.82 Acres

    Florence Commercial Land For Sale

    1.82 acre commercial land near I-95 in Florence, SC.

    Tbd Presbyterian Rd, Florence, SC 29501
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    Prime Commercial Development Site
    $980,000
    4.76 Acres

    Prime Commercial Development Site

    4.76-acre commercial land with high traffic exposure in Florence, SC.

    917 S Cashua Dr, Florence, SC 29501
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    Vacant Corner Lot For Sale
    Contact for pricing

    Vacant Corner Lot For Sale

    Vacant corner lot to be sold via online auction.

    813 Chase St, Florence, SC 29501
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    Prime Commercial Land Near I-95
    $1,500,000
    7.27 Acres

    Prime Commercial Land Near I-95

    7.27 acres of commercial land near I-95 in Florence, SC.

    3312 Meadors Rd, Florence, SC 29501
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    Unzoned Acreage in Florence, SC
    $255,000
    6.54 Acres

    Unzoned Acreage in Florence, SC

    6.54 acres of unzoned land with potential uses.

    6.54 Acres-Tbd Alligator Rd, Florence, SC 29501
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    Florence Commercial Building on Evans
    $79,000
    1,200 SF

    Florence Commercial Building on Evans

    Standalone building on Evans Street with redevelopment potential.

    617 W Evans St, Florence, SC 29501
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    Commercial Lot Near National Cemetery
    $50,000
    0.18 Acres

    Commercial Lot Near National Cemetery

    Unimproved commercial lot near Florence National Cemetery, zoned R-5A.

    Tbd National Cemetery Rd, Florence, SC 29506
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    Commercial Property on S Cashua Drive
    $638,800
    13,801 SF

    Commercial Property on S Cashua Drive

    Three buildings on three lots near Walmart in Florence, SC.

    818 Delmae Dr, Florence, SC 29501
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    Commercial Lot on Darlington Street
    $31,000
    0.19 Acres

    Commercial Lot on Darlington Street

    Vacant commercial lot with frontage on Darlington Street, Florence, SC.

    East Darlington St, Florence, SC 29506
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    Commercial Lot on Darlington Street
    $31,000
    0.19 Acres

    Commercial Lot on Darlington Street

    Commercial lot with frontage on East Darlington Street, Florence, SC.

    East Darlington St, Florence, SC 29506
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    Florence Commercial Land For Sale
    $278,784
    0.64 Acres

    Florence Commercial Land For Sale

    0.64 acre commercial land parcel in Florence, South Carolina.

    Presbyterian Rd, Florence, SC 29501
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    Florence Commercial Lot For Sale
    $1,500,000
    4.02 Acres

    Florence Commercial Lot For Sale

    4.02 acre mixed-use lot with high visibility in Florence, SC.

    1714 2Nd Loop Rd, Florence, SC 29501
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    Vacant Land in Florence, SC
    Contact for pricing

    Vacant Land in Florence, SC

    Vacant lot sold via online auction. Buyer responsible for due diligence.

    813 N Dargan St, Florence, SC 29506
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    Florence Commercial Land For Sale
    $49,900
    0.17 Acres

    Florence Commercial Land For Sale

    B-6 zoned property with commercial and redevelopment options.

    720 S Barringer St, Florence, SC 29506
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    Corner Lot in Florence, SC
    $125,000
    0.10 Acres

    Corner Lot in Florence, SC

    Commercial corner lot available in Florence, South Carolina.

    360 N Dargan St, Florence, SC 29501
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    Florence Office Building For Sale
    $1,500,000
    7,517 SF

    Florence Office Building For Sale

    Office building with 7,517 square feet of space in Florence.

    1706 2Nd Loop Rd, Florence, SC 29501
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    Versatile Commercial Building on Acreage
    $500,000

    Versatile Commercial Building on Acreage

    Single-tenant building with showroom, warehouse, and fenced yard.

    511 Irby St, Florence, SC 29501
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    Mixed-Use Property on Palmetto Street
    $400,000

    Mixed-Use Property on Palmetto Street

    2600 SF residence on 1.6 acres, suitable for conversion.

    2901 W Palmetto St, Florence, SC 29501
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    Former Convenience Store Investment Property
    $125,000
    2,400 SF

    Former Convenience Store Investment Property

    Fixer-upper retail property with 150' frontage, great investment potential.

    1134 E Howe Springs Rd, Florence, SC 29505
    View details

    Florence, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 91 commercial real estate for sale in Florence, SC, showcased through 150 active listings on our real estate platform. These investment opportunities span a total of 23,809,896 square feet of properties for sale, with an estimated market value of $59,363,541.

    Sale prices for business properties in Florence, SC start at $31,000, averaging $1,060,063, and reaching up to $16,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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