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    Anderson, SC Commercial Real Estate for Lease

    80 results
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    Class A Office Space
    $3,400 / Mo

    Class A Office Space

    2315 N Main St, Anderson, SC 29621

    Professional office suite for rent in Anderson, SC.

    • Prime Main Street location ideal for high‑visibility professional business.
    • Class A office building with included maintenance, electric, and water.
    • Versatile 2,800 sq ft suite suitable for medical or professional use.
    • Functional layout with five private offices, open floor plan, two restrooms, and a kitchen area.
    • Includes a welcoming reception area and large parking space.
    Updated: Dec 9, 2025
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    Downtown Anderson Commercial Space For Rent
    $1,150 / Mo
    2,614 SF

    Downtown Anderson Commercial Space For Rent

    122 W Whitner St, Anderson, SC 29624

    Versatile 1,300 SF space in historic downtown Anderson.

    • Prime location in historic downtown Anderson, across from the Anderson County Courthouse.
    • Versatile 1,300 square‑foot upper‑level space suitable for office, retail, or studio.
    • Adjacent to the City Parking Garage with ample street parking available.
    • Wood flooring throughout.
    • Adaptable floor plan.
    Updated: Feb 25
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    Industrial Building in Anderson, SC
    $5,500 / Mo

    Industrial Building in Anderson, SC

    Industrial building suitable for wholesale distribution in Anderson, SC.

    1821 S Mcduffie St, Anderson, SC 29624
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    Retail Space in Whitehall Commons
    $13 SF/Yr

    Retail Space in Whitehall Commons

    Retail or office space available in a high-traffic area.

    1486 Pearman Dairy Rd, Anderson, SC 29625
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    Flex Building with Office/Warehouse Space
    $4,000 / Mo

    Flex Building with Office/Warehouse Space

    Flex building with office and warehouse space for lease.

    113 Old Denver Rd, Anderson, SC 29625
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    Flex Building with Office, Warehouse
    $4,000 / Mo

    Flex Building with Office, Warehouse

    Flex building with office and warehouse space for lease.

    109 Old Denver Rd, Anderson, SC 29625
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    Miracle Mile Commercial Building
    $9 SF/Yr

    Miracle Mile Commercial Building

    Approximately 4000 SF building for lease with high visibility.

    102 Miracle Mile Dr, Anderson, SC 29621
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    Industrial Building Near I-85
    Contact for pricing

    Industrial Building Near I-85

    8,850 SF industrial building with fenced yard near I-85.

    1046 Watkins Road Ext, Anderson, SC 29625
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    Retail Space at Anderson Mall
    Contact for pricing

    Retail Space at Anderson Mall

    Inline retail space available for lease in Anderson, SC.

    3131 N Main St, Anderson, SC 29621
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    Commercial Building Near I-85
    Contact for pricing

    Commercial Building Near I-85

    Commercial building for lease near I-85 in Anderson, SC.

    107 Hurricane Rd, Anderson, SC 29621
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    Downtown Anderson Flex Space Available
    $1,800 / Mo

    Downtown Anderson Flex Space Available

    Flex space for lease in downtown Anderson near redevelopments.

    114-118 Tribble St, Anderson, SC 29625
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    East Greenville Street Office Space
    Contact for pricing
    2,000 SF

    East Greenville Street Office Space

    Office or medical suite with ample parking and high visibility.

    1403 East Greenville St, Anderson, SC 29621
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    Renovated Office Building For Rent
    $1,300 / Mo

    Renovated Office Building For Rent

    Renovated office building with versatile space for rent.

    1311 South Murray Avenue Ext, Anderson, SC 29624
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    Office Space Near Downtown Anderson
    $1,300 / Mo

    Office Space Near Downtown Anderson

    Office suite with three private offices, reception, and kitchenette.

    1214 North Main Street Ext, Anderson, SC 29621
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    Modern Office Space Available
    $500 / Mo

    Modern Office Space Available

    Updated office space with 9 offices, conference room, and breakroom.

    521 N Mcduffie St, Anderson, SC 29621
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    Well-Finished Office Space Available
    $18 SF/Yr

    Well-Finished Office Space Available

    High-visibility office space with ample parking in Anderson, SC.

    1801 N Main St, Anderson, SC 29621
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    Pad Ready Commercial Property
    Contact for pricing

    Pad Ready Commercial Property

    Pad-ready property on a busy corridor near AnMed North Campus.

    1807 E Greenville St, Anderson, SC 29621
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    Subdividable Manufacturing and Distribution Space
    $4 SF/Yr

    Subdividable Manufacturing and Distribution Space

    Approximately 386,000 sq ft available for lease near I-85.

    2415 Highway 81, Anderson, SC 29621
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    Warehouse Building Near Anderson Airport
    $9 SF/Yr

    Warehouse Building Near Anderson Airport

    4960 SF warehouse space available for lease near airport.

    3226 Highway 24, Anderson, SC 29626
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    Renovated Office/Retail Space Available
    $15 SF/Yr

    Renovated Office/Retail Space Available

    Newly renovated 1,200 SF office/retail space for lease.

    1207 Whitehall Rd, Anderson, SC 29625
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    Former Bank Branch with Drive-Thru
    $18 SF/Yr

    Former Bank Branch with Drive-Thru

    Former bank branch with drive-thru located near major retailers.

    3898 Liberty Hwy, Anderson, SC 29621
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    Retail Spaces Available For Lease
    $4 SF/Yr

    Retail Spaces Available For Lease

    Retail spaces for lease at 505-511 Sayre Street.

    505-511 Sayre St, Anderson, SC 29624
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    Retail Land Lease Opportunity
    Contact for pricing

    Retail Land Lease Opportunity

    Land available for ground lease in Anderson, SC retail development.

    3415 Clemson Blvd, Anderson, SC 29621
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    Retail Space on Clemson Blvd
    $25 SF/Yr

    Retail Space on Clemson Blvd

    5,336 SF retail building for lease on Clemson Blvd.

    4022 Clemson Blvd, Anderson, SC 29621
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    Anderson, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Anderson, SC with 246 listings featured on our commercial real estate exchange. The current inventory includes 20,262,613,540 square feet of properties with an estimated lease value of $174 SF/Yr.

    Estimated lease rates for Commercial real estate in Anderson, SC begin at $1.00 SF/Yr, with an average of $11 SF/Yr and extend to $25 SF/Yr.
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