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    Leesburg, FL Commercial Real Estate for Lease

    43 results
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    Medical Office Near UF Health
    $26 SF/Yr
    8,642 SF

    Medical Office Near UF Health

    640 S Lake St, Leesburg, FL 34748

    Medical office space for lease near UF Health Leesburg Hospital.

    • Directly across from UF Health Leesburg Hospital in a key medical hub.
    • 4,072 SQFT medical office space zoned C‑2.
    • Features eight exam rooms, multiple private offices, and a dedicated surgery room with private waiting room.
    • Abundant parking with 44+ spaces.
    • Recently replaced roof (3 years ago).
    Updated: Jan 22
    View details
    Leesburg Mixed-Use Office/Warehouse Facility
    $2,400 / Mo
    1,976 SF

    Leesburg Mixed-Use Office/Warehouse Facility

    2848 W Main St, Leesburg, FL 34748

    Office/warehouse with mixed-use potential in Leesburg Commerce Park.

    • Excellent visibility facing W Main Street in Leesburg Commerce Park.
    • Convenient access to Highway 27, I‑75, and the Turnpike.
    • Mixed‑use potential including office, warehouse, and light manufacturing.
    • Warehouse with a 14‑foot roll‑up door.
    • Features two private offices and a conference room.
    Updated: Nov 11, 2025
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    Leesburg Mixed-Use Highway Frontage
    $1,850 / Mo
    5,400 SF

    Leesburg Mixed-Use Highway Frontage

    Updated mixed-use building with high visibility on US Highway 441.

    1539 Us Highway 441, Leesburg, FL 34748
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    Downtown Leesburg Office Suites
    $4,800 / Mo

    Downtown Leesburg Office Suites

    Office suites available in historic downtown Leesburg.

    711 W Main St, Leesburg, FL 34748
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    Retail Space in Growing Area
    Contact for pricing
    8,700 SF

    Retail Space in Growing Area

    High-visibility retail space with ample parking in Leesburg, Florida.

    911 S 14Th St, Leesburg, FL 34748
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    Medical Office Space Available
    Contact for pricing
    5,396 SF

    Medical Office Space Available

    Move-in ready, renovated medical suites with ample parking.

    600 W North Blvd, Leesburg, FL 34748
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    Leesburg Retail Space Available Immediately
    Contact for pricing
    20,572 SF

    Leesburg Retail Space Available Immediately

    20,572 SF retail space with high visibility in Leesburg.

    27405 Us Highway 27, Leesburg, FL 34748
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    Downtown Leesburg Office Space Available
    $92,962

    Downtown Leesburg Office Space Available

    Leesburg office space for lease in growing downtown area.

    410 W Main St, Leesburg, FL 34748
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    Retail Plaza on Highway 441/27
    $10,080 / Mo

    Retail Plaza on Highway 441/27

    Retail spaces available in Leesburg with high traffic visibility.

    2111-2199 Citrus Blvd, Leesburg, FL 34748
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    Medical Professional Building on US Hwy
    $57,600

    Medical Professional Building on US Hwy

    3,600+/- SF medical professional building for lease on US Hwy

    9846 Us Highway 441, Leesburg, FL 34788
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    Turnkey Medical/Professional Office Space
    $24,750

    Turnkey Medical/Professional Office Space

    Turnkey medical/professional office space for lease in Leesburg, Florida.

    33049 Professional Dr, Leesburg, FL 34788
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    Downtown Leesburg Freestanding Office Building
    $28,800

    Downtown Leesburg Freestanding Office Building

    1,600 SF office building in historic downtown Leesburg.

    2017 W Main St, Leesburg, FL 34748
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    Medical Suite Near UF Health
    $21,000

    Medical Suite Near UF Health

    Medical suite for lease directly across from UF Health.

    601 E Dixie Ave, Leesburg, FL 34748
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    Retail Space on US Highway
    $40,432

    Retail Space on US Highway

    Retail space available in Leesburg with highway frontage.

    25010 Ef /67, Leesburg, FL 34748
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    Retail Space on US Hwy 27
    $22,500

    Retail Space on US Hwy 27

    Retail space for lease in a high-traffic area.

    27900 Us Hwy 27 Hwy, Leesburg, FL 34748
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    Commercial Land For Lease
    Contact for pricing

    Commercial Land For Lease

    Commercial land available for ground lease or build to suit.

    9745 Silver Lake Dr, Leesburg, FL 34788
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    Leesburg Industrial Warehouse and Office
    $48,000

    Leesburg Industrial Warehouse and Office

    Industrial warehouse and office space for lease in Leesburg.

    3601 Parkway Blvd, Leesburg, FL 34748
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    Leesburg Warehouse Space Available
    $100,100

    Leesburg Warehouse Space Available

    7,700 SF warehouse space in Leesburg, available 2/1/2026.

    302 Richey Rd, Leesburg, FL 34748
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    Retail Space Available For Rent
    $63,600

    Retail Space Available For Rent

    Retail space for rent at $11 per square foot.

    1904 A, Leesburg, FL 34748
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    Retail Space in Publix-Anchored Center
    Contact for pricing
    1,090 SF

    Retail Space in Publix-Anchored Center

    Retail space available in Leesburg, Florida with high visibility.

    27615 Us Highway 27, Leesburg, FL 34748
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    Retail Space in Leesburg Center
    Contact for pricing
    2,420 SF

    Retail Space in Leesburg Center

    Retail space available in shopping center anchored by Aldi.

    2219-2241 Citrus Blvd, Leesburg, FL 34748
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    Retail Space in Leesburg Center
    Contact for pricing
    2,086 SF

    Retail Space in Leesburg Center

    Retail space available in shopping center anchored by national tenants.

    2243-2263 Citrus Blvd, Leesburg, FL 34748
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    Retail Space in Growing Leesburg
    Contact for pricing
    200 SF

    Retail Space in Growing Leesburg

    Retail space available in rapidly growing Leesburg, Florida.

    10401 Us Highway 441, Leesburg, FL 34788
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    Retail Space in Palm Plaza
    Contact for pricing
    830 SF

    Retail Space in Palm Plaza

    Retail space for lease in a busy Leesburg shopping center.

    701 N 14Th St, Leesburg, FL 34748
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    Leesburg, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Leesburg, FL with 138 listings featured on our commercial real estate exchange. The current inventory includes 462,520,080 square feet of properties with an estimated lease value of $40 SF/Yr.

    Estimated lease rates for Commercial real estate in Leesburg, FL begin at $14 SF/Yr, with an average of $20 SF/Yr and extend to $26 SF/Yr.
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