649 Main Street, Waltham, MA 02451

Building Details

Year Built

1910

Listing office Lamacchia Realty, Inc. Show Phone

Listing date Jul 2, 2026

Source Corcoran

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All listing content including descriptions, pricing, images are the copyrighted material of Lamacchia Realty, Inc.

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Overview

This two-story commercial building has been recently renovated and is set up with an open floor plan supported by expansive storefront windows for strong natural light. The interior configuration includes multiple private offices or treatment rooms, along with an updated ADA-compliant restroom. A rear service area and separate rear access provide operational flexibility. The space is designed to accommodate a range of professional and service uses, including retail, office, medical, wellness, showroom, creative, or other professional applications.

The property is positioned on busy Main Street in the heart of downtown Waltham, offering visibility to passing traffic. It is located among established businesses, restaurants, and retail shops, with public transportation nearby and access to major commuter routes.

For an owner-user or an operating tenant, the combination of renovated finishes, storefront presence, and dedicated treatment or office rooms can support day-to-day patient or client services while maintaining privacy within the plan. The presence of a rear service area and separate entrance can also help with workflows that benefit from back-of-house access.

Suggested Use

Nursing Home Bed & Breakfast Tattoo & Piercing Shop Pet Grooming Service Arcade & Gaming Center Travel Agency Clothing & Fashion Store (Bike/Boat/Book/etc) Store Daycare Center Restaurant

Zoning and permitted uses should be independently verified with local authorities.

Location Insight

• Map
• Local Demand

City

Waltham

County

Middlesex

State

Massachusetts

Longitude

-71.2363491

Latitude

42.3765869

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FAQs

What type of property is this?

Office building - Renovated two-story suite with ADA-compliant restrooms, private treatment/offices, and separate rear access for flexible healthcare use.

Where is this office building located?

The property is located at 649 Main Street Waltham, MA.

What is the lease rate?

The lease rate is $27 SF/Yr.

What are key features of this property?

This property features: 3,890 SF two‑story commercial building with an open floor plan and expansive storefront windows.; Recently renovated interior with multiple private offices or treatment rooms.; Updated ADA‑compliant restroom(s) included.