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South San Francisco Office Space
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331 Oyster Point Boulevard, South San Francisco, CA 94080

60,000 square foot office space available for rent.

Space SizeContact for details
Days on Market261

Property Features for 331 Oyster Point Boulevard

General Information

Standard status Active
Property subtype LifeSciences
Listing Agency:
Listed By: Mary Hines · License #01281208
Source: Cbre
Added: Nov 22, 2025 Changed: Aug 8 Last Checked: Aug 10 at 10:45AM

Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of Mary Hines

Investment Insights

Based on property information with market context.

This property offers 60,000 square feet of office space and is located in South San Francisco, California.

Key Highlights

  • 60,000 square foot office space available.

Property Analytics

Current Use

Prothena Biosciences Corporate Office Assembly Biosciences Corporate Office

Suggested Use

Top Pick Dental Office Hair Salon Kitchen & Bath Showroom Nail Salon Electrical Service (Bike/Boat/Book/etc) Store

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Lease Details

NNN (Triple Net)
Lease Type

Location Intelligence

Trade Area within ½ mile

975
Businesses Nearby

Demographics for 94080, CA

66,592
Population
23,364
Households
2.9
Avg Household Size
40
Median Age
40%
College-Educated
86%
High-School Grad
10.2 sq mi
ZIP Area
6,529
Density / Sq Mi
$135,966
Median Household Income
$61,138
Median Earnings
$2,840
Median Rent
$1,159,500
Median Home Value

Market

Lease Benchmarks for South San Francisco, CA

$22.86 /SF/Yr
Avg Asking Price
$20.16–$27 /SF/Yr
Price Range
22,635 SF
Avg Space Size

Vacancy Rate% for Office in West region

11% 2019
14.1% 2020
15.5% 2021
17.2% 2022
19.9% 2023
21% 2024
20.8% 2025
Rey
Questions? Ask Rey
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Frequently Asked Questions

What type of property is this?
Office units - 60,000 square foot office space available for rent.
Where is this office units located?
The property is located at 331 Oyster Point Boulevard South San Francisco, CA.
What are key features of this property?
This property features: 60,000 square foot office space available.
More about this property
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