2221 Pamplico Highway, Florence, SC 29505
Two remodeled buildings offer retail and office configurations with on-site parking.
Property Features for 2221 Pamplico Highway
General Information
Site & Location
Amenities
Building Details
Spaces For Lease
at 2221 Pamplico Highway Contact us- Size
- 1,200 SF
- Type
- Office, Retail
- Lease Type
- Modified Gross
- Availability
- Active
Space 1
- Size
- 400 SF
- Type
- Office, Retail
- Lease Type
- Modified Gross
- Availability
- Active
Space 2
Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of Old River Real Estate
Investment Insights
Based on property information with market context.
The property is located at 2221 Pamplico Highway in Florence, between Freedom Boulevard and E Howe Springs/Claussen Road. The area recorded 20,600 VPD in 2025 according to SCDOT traffic data. Surrounding context includes high-density and single-family housing, schools, a hospital, grocery stores, and big-box retail. The property was built in 1955 and may accommodate retail or office users based on its existing configuration.
Key Highlights
- 1,200 SF main building plus a separate 400 SF executive office building
- Both buildings remodeled in recent years
- Approximately 16 parking spaces, including 12 spaces at the rear
Property Analytics
Current Use
Lease Details
Location Intelligence
Trade Area within ½ mile
Demographics for 29505, SC
Market
Vacancy Rate% for Office in South region