222 S Central Ave, Clayton, MO

Spaces For Lease

at 222 S Central Ave Contact us

Listing office CBRE k***@cbre.com Show Phone

Listing date Nov 24, 2025

Source Moodyscre

Displayed information is deemed reliable but is not guaranteed and should be independently verified.

All listing content including descriptions, pricing, images are the copyrighted material of CBRE

Report an issue

---

Overview

This 11-story office building is situated in the heart of Clayton. The building has undergone major renovations, including a newly refinished second-floor lobby and common areas, a building conference center, and a tenant fitness center equipped with new equipment. The property is in close proximity to courthouses, restaurants, and hotels. Its location provides convenient access to the entrance ramp to Clayton from Forest Park Parkway, facilitating quick access in and out of Clayton by car or via the Metrolink. The available office space is 3,346 square feet.

Suggested Use

Auto Repair Shop Auto Parts Store Grocery & Convenience Store Daycare Center Storage Facility Grocery & Convenience Store Food Market Building Supply Discount Store (Bike/Boat/Book/etc) Store

Zoning and permitted uses should be independently verified with local authorities.

Location Insight

• Map
• Local Demand

City

Clayton

County

St. Louis

State

Missouri

Longitude

-90.3237263

Latitude

38.6425518

Nearby Similar for Lease

• 

  $129-$17,029/Mo

  11-1,999 SF

  Sevens Building

  7777 Bonhomme Ave, Unit 1800, Clayton, MO 63105

  View Details
• 

  $129-$17,029/Mo

  11-1,999 SF

  Sevens Building

  7777 Bonhomme Ave, Unit 1800, Clayton, MO 63105

  View Details
• Sponsored

  

  $129-$19,437/Mo

  11-2,041 SF

  Pierre Laclede

  7733 Forsyth Blvd, Unit 11TH, Clayton, MO 63105

  View Details
• 

  $30 SF/Yr

  4,288 SF

  Clayton Office Space Available Now

  Former law firm space with elevator exposure and tenant amenities.

  231 S Bemiston Ave, Clayton, MO

  View Details
• 

  $35 SF/Yr

  2,610 SF

  Class A Office Tower Clayton

  Class A office tower in downtown Clayton for lease.

  8235 Forsyth Blvd, Clayton, MO

  View Details
• 

  $21 SF/Yr

  102,600 SF

  Downtown Clayton Office Building

  Two interconnected office buildings in downtown Clayton with on-site amenities.

  225-235 S Meramec Ave, Clayton, MO 63105

  View Details
• 

  $32 SF/Yr

  1,464 SF

  Clayton CBD Office Space

  Move-in ready office suites in central Clayton location.

  7777 Bonhomme Ave, Clayton, MO

  View Details
• 

  $35 SF/Yr

  4,086 SF

  Class A Office Tower Clayton

  Class A office tower in downtown Clayton for lease.

  8182 Maryland Ave, Clayton, MO

  View Details
• 

  $29 SF/Yr

  1,737 SF

  Downtown Clayton Office Space Available

  Office space for lease in downtown Clayton with amenities.

  150 N Meramec Ave, Clayton, MO

  View Details
• 

  $14 SF/Yr

  350 SF

  Clayton Office Space For Rent

  Office spaces in the heart of Clayton near I-170 & I-64/40.

  30-44 N Brentwood Blvd, Clayton, MO

  View Details
• 

  $29 SF/Yr

  2,372 SF

  Downtown Clayton Office Space Available

  Office space for rent in downtown Clayton, Missouri.

  165 N Meramec Ave, Clayton, MO

  View Details
• 

  $25 SF/Yr

  2,709 SF

  Professionally Managed Office Space Available

  Office space for lease with covered parking and convenient location.

  8151 Clayton Rd, Clayton, MO

  View Details

FAQs

What type of property is this?

Office units - Eleven-story office building in Clayton with recent renovations.

Where is this office units located?

The property is located at 222 S Central Ave Clayton, MO.

What is the lease rate?

The lease rate is $26 SF/Yr.

What are key features of this property?

This property features: Newly renovated building with refinished lobby, conference center, and tenant fitness center.; Prime location in the heart of Clayton.; Convenient access to Forest Park Parkway and Metrolink.