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Cambridge Office Space For Lease
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141 Portland Street, Cambridge, MA 02139

High-quality office space in a prime Cambridge location.

Space SizeContact for details
Days on Market266

Property Features for 141 Portland Street

General Information

Standard status Active
Property subtype Office
Listing Agency: CBRE | Boston
Listed By: Tess Chandler
Source: Cbre
Added: Nov 22, 2025 Changed: Aug 8 Last Checked: Aug 8 at 12:11PM

Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of CBRE | Boston

Investment Insights

Based on property information with market context.

Available for lease is 4,715 to 63,337 square feet of office space at 141 Portland Street in Cambridge, Massachusetts. The space is located on the lower level, floors 1-2, and floors 8-10. The building is situated across from Technology Square and One Kendall Square, providing a location suitable for companies seeking a Kendall Square address. The property is located minutes from downtown Boston, Logan Airport, Harvard Square, and Back Bay. Access is facilitated by Interstate 93, the Red Line Kendall MBTA Station, and the EZ Ride Shuttle Bus. The surrounding neighborhood includes shops, restaurants, and cinemas at Kendall Square. Neighboring institutions and corporations include MIT, Amgen, Biogen, and Novartis.

Key Highlights

  • Prime Kendall Square location, highly desirable for technology and research companies.
  • Excellent access to public transportation (Red Line, EZ Ride Shuttle) and major highways (I‑93).
  • Proximity to major institutions and corporations like MIT, Amgen, Biogen, and Novartis.

Property Analytics

Current Use

Christopher Maynard Financial Advisor edX High School FedEx Drop Box Postal Service Twitter (Bike/Boat/Book/etc) Store Google, Inc (Bike/Boat/Book/etc) Store

Suggested Use

Top Pick Nail Salon Hair Salon Big Box & Wholesale Store Food Market Kitchen & Bath Showroom Nursing Home

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Lease Details

NNN (Triple Net)
Lease Type

Location Intelligence

Trade Area within ½ mile

4,583
Businesses Nearby

Demographics for 02139, MA

39,525
Population
16,930
Households
2.3
Avg Household Size
30
Median Age
78%
College-Educated
94%
High-School Grad
1.6 sq mi
ZIP Area
24,703
Density / Sq Mi
$124,648
Median Household Income
$61,025
Median Earnings
$2,613
Median Rent
$1,066,200
Median Home Value

Market

Lease Benchmarks for Cambridge, MA

$41.67 /SF/Yr
Avg Asking Price
$4.71–$70.87 /SF/Yr
Price Range
9,718 SF
Avg Space Size

Vacancy Rate% for Office in Northeast region

13.1% 2019
15.4% 2020
17.6% 2021
19.1% 2022
20.2% 2023
20.9% 2024
19.9% 2025
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Frequently Asked Questions

What type of property is this?
Office units - High-quality office space in a prime Cambridge location.
Where is this office units located?
The property is located at 141 Portland Street Cambridge, MA.
What are key features of this property?
This property features: Prime Kendall Square location, highly desirable for technology and research companies.; Excellent access to public transportation (Red Line, EZ Ride Shuttle) and major highways (I‑93).; Proximity to major institutions and corporations like MIT, Amgen, Biogen, and Novartis.
More about this property
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