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South San Francisco Office Space
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5000 Shoreline Court, South San Francisco, CA 94080

Office space for rent in South San Francisco life science hub.

Space SizeContact for details
Days on Market262

Property Features for 5000 Shoreline Court

General Information

Standard status Active
Property subtype LifeSciences
Listing Agency: CBRE | San Francisco
Listed By: Chris Jacobs · License #00900432
Source: Cbre
Added: Nov 22, 2025 Changed: Jul 6 Last Checked: Aug 10 at 2:15PM

Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of CBRE | San Francisco

Investment Insights

Based on property information with market context.

This office space, totaling 73,216 square feet, is available for rent. The property is located in the core of the South San Francisco life science hub, known as the birthplace of biotech. It is in proximity to transit options. A spec suite is ready for occupancy.

Key Highlights

  • Spec suite is ready for immediate occupancy.
  • Located in the core of the South San Francisco life science hub.
  • Proximity to transit options.

Property Analytics

Current Use

Bishop-McCann Marketing & Advertising ChargePoint Charging Station Electric Vehicle Charging Station Sing Tao Daily Publishing House Actelion Pathways Home Health Care Service KSI Corporation Logistics Company

Suggested Use

Top Pick Building Supply HVAC Service Real Estate Agency Garden Center Spa & Massage Center Skin Care Clinic

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Lease Details

NNN (Triple Net)
Lease Type

Location Intelligence

Trade Area within ½ mile

585
Businesses Nearby

Demographics for 94080, CA

66,592
Population
23,364
Households
2.9
Avg Household Size
40
Median Age
40%
College-Educated
86%
High-School Grad
10.2 sq mi
ZIP Area
6,529
Density / Sq Mi
$135,966
Median Household Income
$61,138
Median Earnings
$2,840
Median Rent
$1,159,500
Median Home Value

Market

Lease Benchmarks for South San Francisco, CA

$22.86 /SF/Yr
Avg Asking Price
$20.16–$27 /SF/Yr
Price Range
22,635 SF
Avg Space Size

Vacancy Rate% for Office in West region

11% 2019
14.1% 2020
15.5% 2021
17.2% 2022
19.9% 2023
21% 2024
20.8% 2025
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Frequently Asked Questions

What type of property is this?
Office units - Office space for rent in South San Francisco life science hub.
Where is this office units located?
The property is located at 5000 Shoreline Court South San Francisco, CA.
What are key features of this property?
This property features: Spec suite is ready for immediate occupancy.; Located in the core of the South San Francisco life science hub.; Proximity to transit options.
More about this property
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