Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Back to Search
    The Largest CRE Database in the US with Over 1 Million Listings

    331 Oyster Point Boulevard South San Francisco, CA 94080

    View on Map
    Claim this Listing
    Loading data...
    Loading data...
    Loading data...
    For Lease
    Contact for pricing

    60,000 square foot office space available for rent.

    Type:LifeSciences
    Property size:
    60,000 SF
    Added:
    Nov 22, 2025
    Days on Market:
    159
    Last Refresh:
    Apr 5 at 8:50 pm

    Property Features for 331 Oyster Point Boulevard

    General Information

    Standard status
    Active
    Size
    60,000 SF
    Property subtype
    LifeSciences

    We can help!

    Listing Contact
    Mary Hines

    Listing agent Mary Hines License #01281208

    Listing office

    Listing date Nov 22, 2025

    Source Cbre

    Displayed information is deemed reliable but is not guaranteed and should be independently verified.

    All listing content including descriptions, pricing, images are the copyrighted material of Mary Hines

    Overview

    South San Francisco Office Space

    This property offers 60,000 square feet of office space and is located in South San Francisco, California.
    Location Intelligence

    Current Use by Public Records

    Prothena Biosciences Corporate Office Assembly Biosciences Corporate Office

    Suggested Use

    Restaurant Real Estate Agency Law Firm Building Supply Spa & Massage Center Dental Office Auto Repair Shop Big Box & Wholesale Store Hair Salon Nail Salon

    Zoning and permitted uses should be independently verified with local authorities.

    Location Insight

    • Map
    • Local Demand
    City
    South San Francisco
    County
    San Mateo
    State
    California
    Longitude
    -122.387
    Latitude
    37.6626

    Nearby Similar for Lease

    • Sponsored
      Contact for pricing

      CA, South San Francisco - Spaces Oyster Point

      611 Gateway Blvd, South San Francisco, CA 94080
      View Details
    • $2 SF/Yr

      Corner Office Space Available

      Prominent corner office space near transportation and shopping.
      1486 Huntington Avenue, South San Francisco, CA, 94080
      View Details
    • Contact for pricing

      South San Francisco Office/Lab Sublease

      Full floor office/lab space available for sublease through July 2029.
      651 Gateway Boulevard, South San Francisco, CA 94080
      View Details
    • $1.75 SF/Yr

      Office/Warehouse Suite For Rent

      Office/warehouse suite featuring dock-high loading and ample parking.
      461-477 Littlefield Ave, S San Francisco, CA
      View Details
    • Contact for pricing

      Prime Retail Space in California

      Exceptional retail leasing opportunity in a vibrant South San Francisco location.
      200 Airport Boulevard, South San Francisco, CA 94080
      View Details
    • Contact for pricing

      South San Francisco Industrial Building

      Freestanding industrial building with office/lab space for rent.
      250 Hillside Boulevard, South San Francisco, CA, 94080
      View Details
    • Contact for pricing

      Functional Lab/Office Space Available

      Prime location, functional lab/office space near transportation.
      600 Gateway Blvd, South San Francisco, CA 94080
      View Details
    • $2 SF/Yr

      South San Francisco Warehouse Space

      6,000 SF office warehouse with secure yard near Hwy 101.
      150 West Harris Avenue, South San Francisco, CA, 94080
      View Details
    • Contact for pricing

      Oyster Point Flex/Lab Space

      30,140 SF flex/lab space available for lease.
      333 Oyster Point Blvd, South San Francisco, CA 94080
      View Details
    • Contact for pricing

      Class A Lab & Office

      Sublease opportunity: 34,988 SF of Class A lab & office.
      131 Oyster Point Blvd, South San Francisco, CA 94080
      View Details
    • Contact for pricing

      South San Francisco Flex Space

      Flex space available for rent in South San Francisco.
      400 E Jamie Ct, South San Francisco, CA 94080
      View Details
    • Contact for pricing

      Retail Space on Airport Boulevard

      Retail space available for lease in South San Francisco.
      200 Airport Blvd, South San Francisco, CA 94080
      View Details

    FAQs

    What type of property is this?
    Office units - 60,000 square foot office space available for rent.
    Where is this office units located?
    The property is located at 331 Oyster Point Boulevard South San Francisco, CA.
    What are key features of this property?
    This property features: 60,000 square foot office space available.
    (650) 494-5179
    We can help!
    Listing Contact
    Mary Hines
    Real Estate License ID: 01281208
    Learn More
    Request Owner's contact information
    Message sent successfully
    Error
    If you are the owner or broker of this property and would like to edit or remove this listing please send a message to web site administrator.
    Message sent successfully
    Error
    Email to Your Friends
    Link copied to clipboard
    Separate multiple addresses with a comma
    Message sent successfully
    Error

    Realmo Value Estimations

    Realmo estimates a property’s market value using a proprietary methodology that incorporates public data and user-submitted information. This cumulative value is generated by integrating a variety of conventional and innovative methods. 

    Disclaimer

    These figures are not official appraisals and should not be used as a substitute for a valuation performed by a licensed appraiser.
    Actual market value may differ due to factors not captured in the data. Estimates are offered for informational purposes only, and users should conduct independent research before making financial or investment decisions.
    By using this feature, you acknowledge that Realmo is not responsible for actions taken based on these estimates.

    AI approach

    Realmo AI Method estimates property value using machine learning models trained on millions of comparable listings, transactions, and market signals. It analyzes property features, location intelligence data, and current market dynamics to predict the most probable market value in real time.

    Realmo CapRate Calculation

    Realmo calculates the Capitalization Rate (Cap Rate) to help estimate a property's potential return on investment. The Cap Rate is a fundamental metric in commercial real estate that measures the relationship between a property's net operating income and its market value.

    How We Calculate Cap Rate

    Cap Rate Formula:
    Cap Rate (%) = (Net Operating Income / Property Value) × 100

    Net Operating Income (NOI) Formula:
    NOI = Area × Lease Rate × (1 - Vacancy Rate) × (1 - Operating Expense Ratio)

    Components

    Net Operating Income (NOI) represents the annual income a property generates after operating expenses:

    • Area: Building square footage from property records
    • Lease Rate: Annual $/sqft based on market data for the property type and geographic location
    • Vacancy Rate: Percentage of unoccupied space based on market data for the property type and location
    • Operating Expense Ratio: Operating costs as a percentage of income, varies by property type

    Property Value is derived from:

    • Recent sale price (if available)
    • Statistical models using comparable sales
    • AI-powered valuation estimates

    Example Calculation

    For a 100,000 sqft Office Building:

    • Lease Rate: $25.00/sqft/year (market data for Office in this area)
    • Vacancy Rate: 8% (market data for Office in this area)
    • Operating Expense Ratio: 35% (typical for Office properties)
    • Property Value: $15,000,000

    Step 1: Calculate NOI

    NOI = 100,000 × $25.00 × (1 - 0.08) × (1 - 0.35)
    NOI = 100,000 × $25.00 × 0.92 × 0.65
    NOI = $1,495,000/year

    Step 2: Calculate Cap Rate

    Cap Rate = ($1,495,000 / $15,000,000) × 100
    Cap Rate = 9.97%

    Property Type Considerations

    Net Operating Income calculations vary by property type due to different operating expense ratios:

    • Office: Higher expenses (30-40%) for HVAC, utilities, maintenance
    • Retail: Moderate expenses (25-35%) for common area maintenance
    • Industrial/Warehouse: Lower expenses (15-25%) for minimal tenant services
    • Multifamily: Moderate expenses (35-45%) including property management
    • Self-Storage: Lower expenses (25-35%) due to minimal maintenance

    Market lease rates and vacancy rates are specific to each property type and geographic location, reflecting local market conditions.

    Disclaimer

    These calculations are estimates for informational purposes only and should not be used as a substitute for professional financial analysis or appraisal.

    • Cap Rate calculations depend on market data that may change over time
    • Actual operating expenses, lease rates, and vacancy rates may differ from market averages
    • Individual property conditions, lease terms, and tenant quality significantly impact actual NOI
    • Property value estimates are approximations and not official appraisals
    • Cap rates vary widely by market, property condition, and investment risk profile

    Professional Guidance Recommended: Before making any investment or financial decisions, consult with licensed appraisers, commercial real estate brokers, and financial advisors who can evaluate your specific property and circumstances.
    By using this feature, you acknowledge that Realmo is not responsible for investment decisions or actions taken based on these estimates.

    Cap approach

    Capitalization Method calculates value based on estimated net operating income (NOI) and applying a market-based capitalization rate (cap rate), we estimate what a typical investor might be willing to pay for it.

    Comparable approach

    Comparable estimate is based on recent sales of similar nearby properties, adjusted for factors like size, condition, and location.

    Relative

    Relative property class coefficient uses factors that account for typical price differences between various asset types (e.g., retail vs. industrial) to provide a more accurate market-aligned estimate.

    Geo

    Comparable Sales Method, enhanced by Geo coefficients — location-based adjustment factors that reflect differences in price levels across neighborhoods, cities, or regions ensuring a more accurate, market-sensitive valuation.

    Stat Estimate

    This method estimates value based on actual market adjusted recent (~5 years) sales of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all similar sales ($/sqft) are above this value
    • Range-to: 75% of all similar sales ($/sqft) are below this value
    AI Estimate

    This method estimates value based on AI market estimation of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all estimations ($/sqft) are above this value
    • Range-to: 75% of all estimations ($/sqft) are below this value
    Alternative use

    Estimate considers the property’s potential value if used for a different purpose-based on zoning, demand, and market feasibility.

    More about this property
    Thanks! Your message was sent.
    Error! Your message wasn't sent.
    Please enter your name
    Please enter email
    Please enter the email in the correct format
    Please enter phone
    Please enter the number in the correct format
    Please enter message
    Thank You

    You are Unsubscribed From Notifications

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!