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    Murphysboro, IL Commercial Real Estate for Sale

    8 results
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    Historic Murphysboro Event Center
    $650,000
    0.18 Acres

    Historic Murphysboro Event Center

    1329 Walnut St, Murphysboro, IL 62966

    Historic event center and gaming facility in downtown Murphysboro.

    • Turnkey gaming facility and event center (Rosie's Gaming) with business included
    • Historic landmark building ("Old Elks Building") with a grand ballroom and capacity for up to 500 guests
    • Versatile spaces including a lounge, full bar, renovated Great Hall, and kitchens
    • Potential for adaptive reuse as a banquet hall, performance venue, gallery, conference space, or mixed‑use development
    • Prime downtown Murphysboro location
    Updated: Nov 24, 2025
    View details
    Murphysboro Multi-Story Brick Building
    $150,000
    0.28 Acres

    Murphysboro Multi-Story Brick Building

    1501 Pine St, Murphysboro, IL 62966

    14,000 sq ft multi-story building in Murphysboro, Illinois.

    • 14,000 sq ft multi‑story brick building offering generous interior space.
    • Located in the heart of Murphysboro on a corner lot.
    • Suitable for various uses: congregation, nonprofit, daycare, events, or redevelopment (subject to approval).
    • Includes two parcels dedicated to paved parking across the street.
    • Features large gathering areas, offices, classrooms, restrooms, and a kitchen.
    Updated: Nov 13, 2025
    View details
    Mixed-Use Investment Opportunity
    $525,000
    6.16 Acres

    Mixed-Use Investment Opportunity

    Income-generating property with apartments, storage units, and RV/boat parking.

    10543 State Hwy, Murphysboro, IL 62966
    View details
    Murphysboro Commercial Land - 15 Acres
    $900,000
    15.89 Acres

    Murphysboro Commercial Land - 15 Acres

    High-visibility commercial land, prime Murphysboro location.

    Birkner Ln, Murphysboro, IL 62966
    View details
    Murphysboro Commercial Building - Huge Potential
    $59,900
    3,200 SF

    Murphysboro Commercial Building - Huge Potential

    3200 sq ft, two entrances, needs TLC. Great price!

    1012 14Th St, Murphysboro, IL 62966
    View details
    Prime Murphysboro Retail Space
    $635,000
    7,000 SF

    Prime Murphysboro Retail Space

    7,000 SF Retail/Warehouse, High Visibility

    60 Niemann Ln, Murphysboro, IL 62966
    View details
    Meadow Vista Mobile Home Park
    $300,000
    4.22 Acres

    Meadow Vista Mobile Home Park

    15-unit Mobile Home Park in Murphysboro, IL

    1219 20Th St, Murphysboro, IL 62966
    View details
    Murphysboro Duplex Investment
    $123,900
    2,016 SF

    Murphysboro Duplex Investment

    Two-unit rental property, great income potential.

    2202 Illinois Ave, Murphysboro, IL 62966
    View details
    Based on your search, we've compiled 623 Potential Opportunities for your consideration. Besides 8 Active listings in Murphysboro, IL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 611 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Carbondale Flex Space - $249,900
    $249,900

    Carbondale Flex Space - $249,900

    Updated Commercial Building, Excellent Location

    1001 Beadle Dr, Carbondale, IL 62901
    View details
    Remodeled Office Space For Sale
    $249,900
    0.14 Acres

    Remodeled Office Space For Sale

    Remodeled office space in Carbondale, perfect for medical or general use.

    1001 N Beadle Dr, Carbondale, IL 62901
    View details
    DeSoto, IL Mobile Home Park
    $85,000
    1.50 Acres

    DeSoto, IL Mobile Home Park

    High cash flowing mobile home park with expansion potential.

    101 Poplar St, De Soto, IL 62924
    View details
    De Soto, IL Mobile Home Park Investment
    $95,000

    De Soto, IL Mobile Home Park Investment

    High-cash-flow 8-unit mobile home park in Illinois.

    101 Poplar St, De Soto, IL 62924
    View details

    Explore Off-Market Properties in Murphysboro, IL

    Consider similar Off-Market properties in Murphysboro, IL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    4600 Ava Rd

    4600 Ava Rd

    Mixed-use properties • 7,296 SF
    Value Estimation by Request
    4600 Ava Rd, Murphysboro, IL 62966
    View details
    602 Mulberry St

    602 Mulberry St

    Multifamily properties
    Value Estimation by Request
    602 Mulberry St, Murphysboro, IL 62966
    View details
    2202 Illinois Ave

    2202 Illinois Ave

    Multifamily properties • 2,016 SF
    Value Estimation by Request
    2202 Illinois Ave, Murphysboro, IL 62966
    View details
    Birkner Ln

    Birkner Ln

    Commercial real estate
    Value Estimation by Request
    Birkner Ln, Murphysboro, IL 62966
    View details
    1012 14Th St

    1012 14Th St

    Commercial real estate • 3,200 SF
    Value Estimation by Request
    1012 14Th St, Murphysboro, IL 62966
    View details
    1761 Marina Rd

    1761 Marina Rd

    Commercial real estate • 2,400 SF
    Value Estimation by Request
    1761 Marina Rd, Murphysboro, IL 62966
    View details
    60 Niemann Ln

    60 Niemann Ln

    Commercial real estate • 7,000 SF
    Value Estimation by Request
    60 Niemann Ln, Murphysboro, IL 62966
    View details
    1761 Marina Rd

    1761 Marina Rd

    Multifamily properties • 2,400 SF
    Value Estimation by Request
    1761 Marina Rd, Murphysboro, IL 62966
    View details
    330 North St

    330 North St

    Commercial real estate • 2,300 SF
    Value Estimation by Request
    330 North St, Murphysboro, IL 62966
    View details
    714 23Rd St

    714 23Rd St

    Multifamily properties • 1,800 SF
    Value Estimation by Request
    714 23Rd St, Murphysboro, IL 62966
    View details
    8671 Old Rt 13

    8671 Old Rt 13

    Multifamily properties • 5,900 SF
    Value Estimation by Request
    8671 Old Rt 13, Murphysboro, IL 62966
    View details
    2034 Illinois Avenue Ext

    2034 Illinois Avenue Ext

    Multifamily properties • 2,016 SF
    Value Estimation by Request
    2034 Illinois Avenue Ext, Murphysboro, IL 62966
    View details
    Birkner Ln

    Birkner Ln

    Commercial real estate • 15.89 Acres
    Value Estimation by Request
    Birkner Ln, Murphysboro, IL 62966
    View details
    Murphysboro, IL 62966

    Murphysboro, IL 62966

    INDUSTRIAL (GENERAL) • 10.00 Acres
    Value Estimation
    $290,000
    Murphysboro, IL 62966
    View details
    500 19th St

    500 19th St

    INDUSTRIAL (GENERAL) • 14.32 Acres
    Value Estimation
    $280,000
    500 19th St, Murphysboro, IL 62966-1704
    View details
    Murphysboro, IL 62966

    Murphysboro, IL 62966

    INDUSTRIAL (GENERAL) • 3.63 Acres
    Value Estimation
    $465,000
    Murphysboro, IL 62966
    View details

    Murphysboro, IL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 464 commercial real estate investment opportunities in Murphysboro, IL with 8 listings featured on our commercial real estate marketplace. The current inventory includes 21,069,255 square feet of properties with an estimated value of $53,483,000.

    Estimated prices for commercial real estate in Murphysboro, IL begin at $30,000, with an average of $243,104 and extend to $900,000.

    In Murphysboro, IL, current investment values show:

    • Other commercial real estate positioned at $242,265
    • Office Properties & Spaces measuring $219,687
    • Other office properties assessed at $219,687
    • Industrial properties calculated at $311,666
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    Most Searched ZIP Codes in Murphysboro, IL

    • 62966

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