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    Murphysboro, IL Commercial Real Estate for Sale

    6 results
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    Historic Murphysboro Event Center
    $650,000
    0.18 Acres

    Historic Murphysboro Event Center

    1329 WALNUT Street, Murphysboro, IL 62966

    Historic event center and gaming facility in downtown Murphysboro.

    • Turnkey gaming facility and event center (Rosie's Gaming) with business included
    • Historic landmark building ("Old Elks Building") with a grand ballroom and capacity for up to 500 guests
    • Versatile spaces including a lounge, full bar, renovated Great Hall, and kitchens
    • Potential for adaptive reuse as a banquet hall, performance venue, gallery, conference space, or mixed‑use development
    • Prime downtown Murphysboro location
    Updated: Oct 21, 2025
    View details
    Murphysboro Multi-Story Brick Building
    $150,000
    0.28 Acres

    Murphysboro Multi-Story Brick Building

    1501 PINE Street, Murphysboro, IL 62966

    14,000 sq ft multi-story building in Murphysboro, Illinois.

    • 14,000 sq ft multi‑story brick building offering generous interior space.
    • Located in the heart of Murphysboro on a corner lot.
    • Suitable for various uses: congregation, nonprofit, daycare, events, or redevelopment (subject to approval).
    • Includes two parcels dedicated to paved parking across the street.
    • Features large gathering areas, offices, classrooms, restrooms, and a kitchen.
    Updated: Jul 29, 2025
    View details
    Commercial Land on High-Traffic Highway
    $450,000

    Commercial Land on High-Traffic Highway

    Commercial land suitable for retail, restaurant, hotel, and more.

    COUNTRY CLUB Road, Murphysboro, IL 62966
    View details
    Mixed-Use Investment Opportunity
    $525,000
    6.16 Acres

    Mixed-Use Investment Opportunity

    Income-generating property with apartments, storage units, and RV/boat parking.

    10543 State Highway 149, Murphysboro, IL 62966
    View details
    Versatile Commercial Space in Murphysboro
    $89,900
    1,701 SF

    Versatile Commercial Space in Murphysboro

    Adaptable commercial property suitable for various business or educational purposes.

    507 N 9th, Murphysboro, IL 62966
    View details
    Murphysboro Multifamily Portfolio Investment Opportunity
    $1,190,000
    21,996 SF

    Murphysboro Multifamily Portfolio Investment Opportunity

    27-unit, six-property multifamily portfolio in Murphysboro, Illinois for sale.

    153 Youngman Rd, Murphysboro, IL 62966
    View details
    Based on your search, we've compiled 621 Potential Opportunities for your consideration. Besides 6 Active listings in Murphysboro, IL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 611 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Executive Office in Cedar Court
    $359,900
    0.40 Acres

    Executive Office in Cedar Court

    Modern, updated executive offices in Carbondale's premier office park.

    1160 CEDAR Court, Carbondale, IL 62901
    View details
    Carbondale Commercial Building For Sale
    $489,000
    0.58 Acres

    Carbondale Commercial Building For Sale

    One-story building in premier business park, adaptable for various uses.

    1235 CEDAR Court, Carbondale, IL 62901
    View details
    Remodeled Office Space For Sale
    $249,900
    0.14 Acres

    Remodeled Office Space For Sale

    Remodeled office space in Carbondale, perfect for medical or general use.

    1001 N Beadle Drive, Carbondale, IL 62901
    View details
    Carbondale Medical Office Building
    $489,000

    Carbondale Medical Office Building

    Adaptable medical office in premier business park.

    1235 CEDAR Court, Carbondale, IL 62901
    View details

    Explore Off-Market Properties in Murphysboro, IL

    Consider similar Off-Market properties in Murphysboro, IL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    115 8th St

    115 8th St

    COMMERCIAL (GENERAL)
    Value Estimation by Request
    115 8th St, Murphysboro, IL 62966-2624
    View details
    17th St

    17th St

    VACANT COMMERCIAL LAND • 0.06 Acres
    Value Estimation by Request
    17th St, Murphysboro, IL 62966
    View details
    17th St

    17th St

    VACANT COMMERCIAL LAND • 0.06 Acres
    Value Estimation by Request
    17th St, Murphysboro, IL 62966
    View details
    17th St

    17th St

    VACANT COMMERCIAL LAND • 0.06 Acres
    Value Estimation by Request
    17th St, Murphysboro, IL 62966
    View details
    Murphysboro, IL 62966

    Murphysboro, IL 62966

    COMMERCIAL (GENERAL) • 0.06 Acres
    Value Estimation by Request
    Murphysboro, IL 62966
    View details
    113 12th St

    113 12th St

    COMMERCIAL (GENERAL) • 0.27 Acres
    Value Estimation by Request
    113 12th St, Murphysboro, IL 62966-2106
    View details
    430 11th St

    430 11th St

    COMMERCIAL CONDOMINUIM
    Value Estimation by Request
    430 11th St, Murphysboro, IL 62966-2178
    View details
    110 6th St

    110 6th St

    COMMERCIAL (GENERAL)
    Value Estimation by Request
    110 6th St, Murphysboro, IL 62966-2646
    View details
    Murphysboro, IL 62966

    Murphysboro, IL 62966

    COMMERCIAL (GENERAL) • 0.53 Acres
    Value Estimation by Request
    Murphysboro, IL 62966
    View details
    Murphysboro, IL 62966

    Murphysboro, IL 62966

    VACANT COMMERCIAL LAND • 0.76 Acres
    Value Estimation by Request
    Murphysboro, IL 62966
    View details
    Murphysboro, IL 62966

    Murphysboro, IL 62966

    COMMERCIAL (GENERAL)
    Value Estimation by Request
    Murphysboro, IL 62966
    View details
    223 13th St

    223 13th St

    OFFICE (GENERAL) • 0.50 Acres
    Value Estimation by Request
    223 13th St, Murphysboro, IL 62966-2512
    View details
    Murphysboro, IL 62966

    Murphysboro, IL 62966

    COMMERCIAL (GENERAL) • 0.89 Acres
    Value Estimation by Request
    Murphysboro, IL 62966
    View details
    1106 Locust St

    1106 Locust St

    COMMERCIAL (GENERAL) • 0.04 Acres
    Value Estimation by Request
    1106 Locust St, Murphysboro, IL 62966-2119
    View details
    1904 Walnut St

    1904 Walnut St

    COMMERCIAL (GENERAL) • 0.16 Acres
    Value Estimation by Request
    1904 Walnut St, Murphysboro, IL 62966-1910
    View details
    2036 Spruce St

    2036 Spruce St

    COMMERCIAL (GENERAL) • 1.01 Acres
    Value Estimation by Request
    2036 Spruce St, Murphysboro, IL 62966-2341
    View details
    Murphysboro, IL 62966

    Murphysboro, IL 62966

    VACANT COMMERCIAL LAND
    Value Estimation by Request
    Murphysboro, IL 62966
    View details
    17 Ventura Ln

    17 Ventura Ln

    COMMERCIAL (GENERAL) • 1.79 Acres
    Value Estimation by Request
    17 Ventura Ln, Murphysboro, IL 62966
    View details

    Murphysboro, IL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 617 commercial real estate for sale in Murphysboro, IL, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 1,017,126 square feet of properties for sale, with an estimated market value of $2,860,000.

    Sale prices for business properties in Murphysboro, IL start at $150,000, averaging $572,000, and reaching up to $900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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