Putnam County, FL Commercial Real Estate for Sale

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Updated: Nov 25, 2025

Medical Office Building with Imaging Rooms

6905 OLD WOLF BAY Road, Palatka, FL 32177

$980,000

6,420 sqft 1.02 AC lot

6,420 SF medical office building currently used as Putnam Diagnostic Imaging Center
Located just SW of HCA Florida Putnam Hospital in a well‑established medical district
1.02 +/- acres with 150 ft of road frontage
Imaging‑ready layout includes MRI, CT, X‑ray, bone density, and mammography rooms plus exam room and physician offices
Zoned C‑1A (Commercial, Neighborhood District) for retail, medical, and professional office uses

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Here's a quick look at some key insights for

6905 OLD WOLF BAY Road, Palatka, FL 32177

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Est. Cap Rate

8.9%
Above avg (5.9%)
Est. NOI

$87K
Annual
Price @ 7% Cap

$1.24M
Above asking
Property Type

Professional Building
Built 1997

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Updated: Apr 20

Flex Warehouse with Office Space

607 N PALM Avenue, Palatka, FL 32177

$799,900

12,120 sqft 1.53 AC lot

Expansive commercial building with 12,000+ total sqft on 1.53 acres, including 6,489 sqft heated/cooled space
Approximately 210 ft of frontage on Palm Ave with two driveways and AADT of 5,900 vehicles
Metal roof installed in 2007; central heating and central air
13 parking spaces plus three roll‑up doors (one side, two rear) and a detached truck‑height loading dock
Fenced storage area and chain‑link fencing; includes public water and septic tank sewer

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Mixed-Use STR Portfolio with Warehouse

100 PILOTHOUSE Court, Palatka, FL 32177

$2,499,000

11,839 sqft 9.08 AC lot

Seven-building 11-unit STR and long-term income portfolio plus 5,500 SF warehouse with integrated office in Palatka.

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Melrose Retail Investment Opportunity

881 N State Rd 21, Melrose, FL

$1,188,337

9,440 sqft 2.96 AC lot

NNN leased Family Dollar with CPI-linked increases.

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East Palatka Commercial Development Opportunity

138 STATE ROAD 207, East Palatka, FL 32131

$1,375,000

1,120 sqft 2.01 AC lot

2.01-acre commercial land with high visibility and diverse zoning.

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Former Bank Office Building

350 N SUMMIT Street, Crescent City, FL 32112

$949,000

3,290 sqft 0.67 AC lot

Former bank building with lobby, private offices, drive-through lanes, and a built-in vault on two entrances.

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Palatka Commercial Property with Residence

101 E HARRIS Street, Palatka, FL 32177

$225,000

1,920 sqft 0.27 AC lot

Commercial property with a residence in historic Palatka, Florida.

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Melrose Mixed-Use Commercial Center

307/309 STATE ROAD 26, Melrose, FL 32666

$949,000

0.76 AC lot

Two attractive buildings in the heart of Melrose, Florida.

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Commercial Land with Office Building

6100 CRILL Avenue, Palatka, FL 32177

$289,900

1,088 sqft 1.83 AC lot

Nearly cleared 1.83-acre site with C-1 and R-2 zoning and an existing 1,088 sq ft mixed-use office/residential building.

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Freestanding Retail and Service Building

111 N Summit Street, Crescent City, FL 32112

$275,000

7,504 sqft 0.23 AC lot

Freestanding commercial building on Highway 17 with showroom/retail space and a separate shop, warehouse, or garage area.

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Melrose Country Retreat with Pool

101 Ramsey Drive, Melrose, FL 32666

$895,000

3,516 sqft 10.00 AC lot

Spacious Melrose home on 10+ acres with pool and pond.

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Country Farm Estate with Pool

101 RAMSEY DRIVE, Melrose, FL 32666

$895,000

3,516 sqft 10.30 AC lot

Move-in ready 4-bedroom home on 10+ acres with a renovated interior, stocked pond, and resort-style pool setting.

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Turnkey Family Medical Practice

1326 FL-100, Melrose, FL 32666

$480,000

2,624 sqft 0.64 AC lot

Operating primary care and obstetric practice with 20-room layout designed for exam, administration, nursing, and lab draw services.

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Turnkey Family Medical Practice Facility

1326 State Road 100, Melrose, FL 32666

$480,000

2,624 sqft

Well-maintained 20-room family practice with obstetric care, administrative support space, and Rural Health Center eligibility.

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Signalized Intersection Commercial Land

738 S HIGHWAY 17, San Mateo, FL 32187

$299,000

1.51 AC lot

C-2 zoned land with strong highway visibility and existing utilities, positioned at a signalized intersection for redevelopment.

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C-2 Zoned Commercial Development Site

738 S HIGHWAY 17, San Mateo, FL 32187

$299,000

1.51 AC lot

Signalized-intersection frontage and neighboring retailers support a range of redevelopment and service uses under C-2 zoning.

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Commercial Land Development Site

138 State Road 207, East Palatka, FL 32131

$1,375,000

1,120 sqft 2.01 AC lot

2.01-acre C-3-zoned site with strong SR 207 frontage and visibility, suited for a range of commercial uses.

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Highway 17 Commercial Building

111 N SUMMIT STREET, Crescent City, FL 32112

$275,000

7,500 sqft 0.23 AC lot

7,500 SF mixed-use building on Highway 17 in Florida.

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209,278 RSF Shopping Plaza

400 N State Road 19, Palatka, FL 32177

$12,012,500

209,278 sqft 27.46 AC lot

209,278 RSF shopping plaza on 27.46 acres.

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Standalone Retail-Office Building

203 Laurel St, Palatka, FL 32177

$584,500

0.05 AC lot

Standalone waterview building near the St. Johns River, with downtown DR zoning and parking lot access in front.

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Former Restaurant on Large Lot

175 US-17, East Palatka, FL 32131

$1,450,000

2,265 sqft 1.08 AC lot

Former restaurant building on a 1.08 acre lot.

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Medical/Professional Office Condo

205 Zeagler Drive, Palatka, FL 32177

$669,000

3,576 sqft 0.05 AC lot

Condo office unit currently tenant-occupied, suitable for owner use or long-term leasing, with possible division into two units.

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Riverfront Acreage on St. Johns

227 S. Highway 17, East Palatka, FL 32131

$649,000

1 sqft

Over an acre of wooded riverfront property near St. Augustine.

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Commercial Land with Road Frontage

1101 N Summit Street, Crescent City, FL 32112

$199,000

0.79 AC lot

Vacant parcel with road frontage and GC-1 zoning, supporting retail and financial development options.

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Putnam County, FL Commercial Real Estate Market Trends and Statistics

Explore 177 commercial real estate for sale in Putnam County, FL, showcased through 177 active listings on our real estate platform. These investment opportunities span a total of 3,389,698 square feet of properties for sale, with an estimated market value of $51,851,521.

Sale prices for business properties in Putnam County, FL start at $54,000, averaging $1,178,443, and reaching up to $12,012,500 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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