Lauderdale County, AL Commercial real estate for sale

Renovated Commercial Building in Florence

$460,000

1,595 SF

Renovated Commercial Building in Florence

715 Cox Creek Pkwy, Florence, AL 35630

Turnkey commercial space in a sought-after Florence location.

Prime commercial location in a highly desirable and established business area of Florence.
Recently replaced HVAC system and roof (2024) reducing near‑term maintenance costs.
Move‑in ready condition with updated, well‑maintained finishes.
Functional floor plan with five private offices, a spacious conference room, full kitchen/break area, and two bathrooms.
1,595± sq ft building suitable for professional, medical, or service‑based businesses.

Updated: Feb 17

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Downtown Florence Medical Office Building

$2,950,000

14,477 SF

Downtown Florence Medical Office Building

201 E Dr Hicks Blvd, Florence, AL 35630

2.5-story medical office building in high-traffic downtown location.

High‑traffic downtown location with significant frontage on two streets (E. Dr. Hicks Blvd & Seminary St).
Substantial 14,477+\/- sq ft medical office building.
Versatile interior layout featuring multiple waiting rooms, exam rooms, private offices, and a conference room.
Existing infrastructure includes a drive‑thru, originally built for a bank.
Renovated in 2006.

Updated: Dec 29, 2025

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$1,175,000

8,750 SF

Commercial Office Building in Florence

Prime commercial office building in high-traffic downtown Florence, Alabama.

302 W Dr Hicks Blvd, Florence, AL 35630

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$559,900

3.19 Acres

Florence Blvd Commercial Opportunity

3.19-acre commercial parcel with high visibility and accessibility.

4055 Florence Blvd, Florence, AL 35634

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$794,000

3,876 SF

Florence Office Building For Sale

3,876 sq ft office building in high-traffic Florence location.

201 S Cox Creek Pkwy, Florence, AL 35630

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$589,000

5.00 Acres

Cleared Commercial Land in Florence, AL

5-acre commercial land in established corridor near national retailers.

00 County Road 46, Florence, AL 35630

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$589,000

4.89 Acres

Prime Commercial Land in Florence, AL

Cleared, level 4.89-acre commercial tract in established corridor.

County Road 46, Florence, AL 35630

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$349,900

2,400 SF

Commercial Property with Highway Access

Commercial property in Killen, AL, with easy highway access.

78 Commerce Way, Killen, AL 35645

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Rogersville Commercial Property on Highway

$549,000

1.45 Acres

Rogersville Commercial Property on Highway

Corner commercial property with high visibility and multiple metal structures.

16935 Highway 72, Rogersville, AL 35652

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Well-Maintained Church Building on 0.86 Acres

$425,000

3,906 SF

Well-Maintained Church Building on 0.86 Acres

Church building on 0.86 acres, perfect for ministries.

3651 Cole Ave, Florence, AL 35630

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Downtown Florence Commercial Opportunity

$1,950,000

28,429 SF

Downtown Florence Commercial Opportunity

37,579 SF facility in downtown Florence, Alabama for sale.

502 S Court St, Florence, AL 35630

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$544,000

0.75 Acres

Florence Commercial Land Opportunity

Three parcels of land with frontage on Pine Street.

000 Patterson Dr, Florence, AL 35630

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$915,000

6.07 Acres

Highway Frontage Commercial Land

Commercial property with highway frontage, metal building, and utilities.

13340 Highway 20, Florence, AL 35633

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$99,900

1,000 SF

Waterloo Commercial Building For Sale

Restaurant/business opportunity in downtown Waterloo with two buildings.

339 Main St, Waterloo, AL 35677

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$549,000

0.48 Acres

Commercial Lot Near Retail Hub

Corner lot with commercial potential near Walmart and Zaxby's.

Florence, AL 35633

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$1,300,000

7,962 SF

Updated Office Space in Florence

Updated office building in downtown Florence, ready for immediate occupancy.

109 N Court St, Florence, AL 35630

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$750,000

75.00 Acres

Highway Frontage Agricultural Land

75-acre land with highway frontage near Florence, Alabama.

1 Highway 20, Florence, AL 35633

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Versatile Commercial Building in Florence

$399,900

2,259 SF

Versatile Commercial Building in Florence

High-visibility commercial building with ample parking and updated facilities.

121 S Chestnut St, Florence, AL 35630

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Commercial Property in High-Traffic Area

$50,000

960 SF

Commercial Property in High-Traffic Area

B2-zoned commercial property with high potential in Florence, Alabama.

115 Indiana Ave, Florence, AL 35630

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$350,000

26.00 Acres

26 Acres Hunting and Farmland

Hardwood timber, pond, and farmland near town amenities.

8951 County Road 11, Florence, AL 35633

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$207,000

5.50 Acres

Killen Acreage with Barn

5.5 acres of level land with barn and fenced pastures.

8235 County Road 25, Killen, AL 35645

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$179,900

1,485 SF

Charming Farmhouse on Spacious Lot

Two-bedroom farmhouse with original hardwood floors on large lot.

235 County Road 7, Florence, AL 35630

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$129,900

15.40 Acres

Lexington Vacant Land with Pasture

15.4 acres of pasture and timberland with utilities.

2 County Road 496, Lexington, AL 35648

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$425,000

0.91 Acres

Commercial Lot on Highway 72

Commercial lot with highway frontage, Rogersville, Alabama.

16402 Highway 72, Rogersville, AL 35652

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Lauderdale County, AL Commercial Real Estate Investment Opportunities Market Analysis

Explore 136 commercial real estate for sale in Lauderdale County, AL, showcased through 310 active listings on our real estate platform. These investment opportunities span a total of 29,848,619 square feet of properties for sale, with an estimated market value of $51,738,590.

Sale prices for business properties in Lauderdale County, AL start at $42,500, averaging $608,689, and reaching up to $4,300,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Lauderdale County, AL Commercial Real Estate for Sale

Renovated Commercial Building in Florence

Turnkey commercial space in a sought-after Florence location.