Lauderdale County, AL commercial real estate for sale

Downtown Rogersville Commercial Investment Property

$209,000

6,699 SF

Downtown Rogersville Commercial Investment Property

1625 Lee St, Rogersville, AL 35652

Prime commercial investment in historic downtown Rogersville, Alabama.

Prime commercial investment property.
Located in growing Historic Downtown Rogersville.
Approximately 3,300 sq ft main level plus 3,300 sq ft upstairs (total 6,600 sq ft).
Currently occupied by an Upscale Consignment Shop.
Central heating and cooling.

Updated: Aug 13, 2025

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Downtown Florence Medical Office Building

$2,950,000

14,477 SF

Downtown Florence Medical Office Building

201 E Dr Hicks Blvd, Florence, AL 35630

2.5-story medical office building in high-traffic downtown location.

High‑traffic downtown location with significant frontage on two streets (E. Dr. Hicks Blvd & Seminary St).
Substantial 14,477+\/- sq ft medical office building.
Versatile interior layout featuring multiple waiting rooms, exam rooms, private offices, and a conference room.
Existing infrastructure includes a drive‑thru, originally built for a bank.
Renovated in 2006.

Updated: Nov 12, 2025

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$1,300,000

7,962 SF

Updated Office Space in Florence

Updated office building in downtown Florence, ready for immediate occupancy.

109 N Court St, Florence, AL 35630

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Downtown Florence Commercial Building For Sale

$725,000

2,760 SF

Downtown Florence Commercial Building For Sale

Commercial building in downtown Florence, Alabama, with investment potential.

111 N Court St, Florence, AL 35630

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Versatile Commercial Building in Florence

$399,900

0.38 Acres

Versatile Commercial Building in Florence

High-visibility commercial building with ample parking and updated facilities.

121 S Chestnut St, Florence, AL 35630

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$99,900

1,000 SF

Waterloo Commercial Building For Sale

Restaurant/business opportunity in downtown Waterloo with two buildings.

339 Main St, Waterloo, AL 35677

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Well-Maintained Church Building on 0.86 Acres

$425,000

3,906 SF

Well-Maintained Church Building on 0.86 Acres

Church building on 0.86 acres, perfect for ministries.

3651 Cole Ave, Florence, AL 35630

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$794,000

3,876 SF

Florence Office Building For Sale

3,876 sq ft office building in high-traffic Florence location.

201 S Cox Creek Pkwy, Florence, AL 35630

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Downtown Florence Commercial Opportunity

$1,950,000

28,429 SF

Downtown Florence Commercial Opportunity

37,579 SF facility in downtown Florence, Alabama for sale.

502 S Court St, Florence, AL 35630

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$1,175,000

8,750 SF

Commercial Office Building in Florence

Prime commercial office building in high-traffic downtown Florence, Alabama.

302 W Dr Hicks Blvd, Florence, AL 35630

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$2,200,000

Industrial Space with Office Component

Industrial space featuring offices and conference room in industrial park.

4504 Helton Dr, Florence, AL 35630

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$1,100,000

Downtown Florence Two-Story Office Building

Two-story office building in downtown Florence with recent updates.

301 E Limestone St, Florence, AL 35630

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$465,000

Updated Office Building For Sale

Commercial office building in a prime, high-demand location.

715 Cox Creek Pkwy, Florence, AL 35630

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$499,900

1,892 SF

Hwy 72 Commercial Property, 5 Acres

High-traffic location, versatile commercial space.

5852 Highway 72, Killen, AL 35645

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$1,200,000

8,114 SF

High-Traffic Hwy 72 Commercial Land

15 Acres, 8,114 sqft, High Visibility

2154 Highway 72, Killen, AL 35645

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$1,100,000

6,000 SF

Downtown Florence Commercial Gem

Historic Loft & Retail Space - High Potential

217 Court St, Florence, AL 35630

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$825,000

2,359 SF

Florence Blvd Commercial Property

High-Visibility Restaurant Site, 2,359 sq ft

909 Florence Blvd, Florence, AL 35630

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$750,000

5.00 Acres

High-Potential Florence Commercial Land

Five Acres, Prime Location, High Visibility

Cox Creek Pkwy, Florence, AL 35630

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$425,000

3,379 SF

2 treatment rooms

5 restrooms

6459 Highway 72, Killen, AL 35645

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$95,000

800 SF

Prime Killen Commercial Property

800 sq ft, 0.82 acre lot, great potential

4721 Co Rd, Killen, AL 35645

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High-Visibility Commercial Land in Killen, AL

$599,900

1.69 Acres

High-Visibility Commercial Land in Killen, AL

Prime Highway 72 location, 1.69 acres, high traffic.

5390 Highway 72, Killen, AL 35645

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$525,000

8,862 SF

9993 Highway 64, Lexington, AL 35648

Office Properties & Spaces • 8,862 SF

9993 Highway 64, Lexington, AL 35648

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Lexington Commercial Building - High Visibility

$395,000

4,690 SF

Lexington Commercial Building - High Visibility

Prime location, 4,690 sq ft commercial space.

11257 Highway 101, Lexington, AL 35648

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$399,900

4,215 SF

Prime Florence Commercial Building

Versatile space, high visibility, move-in ready.

121 Chestnut St, Florence, AL 35630

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Lauderdale County, AL Commercial Real Estate Investment Opportunities Market Analysis

Explore 1879 commercial real estate investment opportunities in Lauderdale County, AL with 283 listings featured on our commercial real estate marketplace. The current inventory includes 140,935,658 square feet of properties with an estimated value of $504,963,097.

Estimated prices for commercial real estate in Lauderdale County, AL begin at $30,000, with an average of $444,901 and extend to $13,395,000.

In Lauderdale County, AL, current investment values show:

Office Properties & Spaces positioned at $443,794
Office buildings measuring $424,896
Investment properties assessed at $495,164
Mixed-use properties calculated at $498,260

Lauderdale County, AL Commercial Real Estate for Sale

Downtown Rogersville Commercial Investment Property

Prime commercial investment in historic downtown Rogersville, Alabama.