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    Research Triangle Park, NC Commercial Real Estate for Lease

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    Charlotte, NC Raleigh, NC Greensboro, NC
    152 results
    Versatile Office/Medical Space Available
    $3,000/Mo
    2,400 SF

    Versatile Office/Medical Space Available

    3925 N Duke Street, Durham, NC 27704

    2400 sq ft office/medical suite in prime Durham location.

    • Prime Durham location, minutes from downtown and Duke Regional Hospital.
    • Versatile 2400 sq ft space suitable for office, medical, or service‑based businesses.
    • Five private offices plus open central workspace.
    • Previously configured for dental and salon use.
    • Large reception area ideal for client‑facing businesses.
    Updated: Feb 18
    View details
    Durham Office Condo For Lease
    $1,500/Mo
    478 SF

    Durham Office Condo For Lease

    3201 Yorktown Ave., Durham, NC 27713

    Recently remodeled office condo with easy access and great location.

    • Recently remodeled with new paint, flooring, ceilings, light fixtures, updated bathroom and kitchenette, and new HVAC system
    • Easy access from parking lot
    • Convenient location: Minutes to Hwy 40 and 885
    • Proximity to Amenities: 2 Miles to Lowes Shopping Plaza, 4 Miles to RTP, 5 Miles to Southpoint Mall and Downtown Durham
    • Includes a brand new refrigerator
    Updated: Feb 10
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    Office Suite with Private Offices
    $36,000 SF/Yr
    1,760 SF

    Office Suite with Private Offices

    Office suite featuring multiple private office spaces for rent.

    5315 Highgate Drive, Durham, NC 27713
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    Durham Office Space For Lease
    $45,045 SF/Yr
    2,145 SF

    Durham Office Space For Lease

    Flexible office unit with ample parking and recent upgrades.

    1906 Carolina 54, Durham, NC 27713
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    NC, Durham - Spaces Mangum Street
    Contact for pricing

    NC, Durham - Spaces Mangum Street

    We offer workspace options fully tailored to your needs in NC, Durham - Spaces Mangum Street

    555 Mangum St, Unit 100, Durham, NC 27701
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    NC, Durham - 3511 Shannon Road
    Contact for pricing

    NC, Durham - 3511 Shannon Road

    Discover many ways to work your way in NC, Durham - 3511 Shannon Road

    3511 Shannon Rd, Durham, NC 27707
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    Versatile Building Available for Lease/Sale
    $3,950,000 SF/Yr
    9,790 SF

    Versatile Building Available for Lease/Sale

    Adaptable building suitable for restaurant, fitness, or office use.

    211 Rigsbee Ave, Durham, NC 27701
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    RTP Imperial
    Contact for pricing

    RTP Imperial

    Discover many ways to work your way in RTP Imperial

    4819 Emperor Blvd, Unit 400, Durham, NC 27703
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    Durham Medical/Office Building for Lease
    $23 SF/Yr
    4,769 SF

    Durham Medical/Office Building for Lease

    Freestanding 4,769 SF building suitable for medical or office use.

    110 E. Carver Street, Durham, NC 27704
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    Professional Office Condos For Lease
    $2,400/Mo
    5,120 SF

    Professional Office Condos For Lease

    Office condos for lease near Duke University Medical Center.

    2741 Campus Walk Ave, Building 400, Durham, NC 27705
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    Durham Office and Retail Space
    $27 SF/Yr
    16,679 SF

    Durham Office and Retail Space

    Office and retail suites available for lease in Durham.

    404 Hunt Street, Durham, NC 27701
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    Retail Space on N Duke
    $3,000/Mo
    2,400 SF

    Retail Space on N Duke

    Retail space available for rent on N Duke Street.

    3925 N Duke Street 121, Durham, NC 27704
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    Plug and Play Lab Space
    $30 SF/Yr
    94,603 SF

    Plug and Play Lab Space

    Move-in ready lab and office space in Durham, NC.

    4025 Stirrup Creek Drive, Durham, NC 27703
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    Historic Brick Building in Durham
    $33 SF/Yr
    19,931 SF

    Historic Brick Building in Durham

    Historic 91,168 SF brick building in Durham's Warehouse District.

    333 Liggett Street, Durham, NC 27701
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    Prime Medical Office Space Available
    $18 SF/Yr
    2,312 SF

    Prime Medical Office Space Available

    Versatile medical/office space in Durham's thriving North Duke corridor.

    2609 N Duke Street, Durham, NC 27704
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    Office Space Available For Rent
    $34 SF/Yr
    18,502 SF

    Office Space Available For Rent

    Office space for rent with convenient parking and amenities.

    215 Morris Street, Durham, NC 27701
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    Class A Office Space
    $23 SF/Yr
    79,440 SF

    Class A Office Space

    Class A office space for lease in North Durham.

    4321 Medical Park Dr, Durham, NC 27704
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    Office/Medical Building Near Southpoint Mall
    $26 SF/Yr
    18,395 SF

    Office/Medical Building Near Southpoint Mall

    Single-story office/medical building near Southpoint Mall available for lease.

    5501 Fortunes Ridge Drive, Durham, NC 27713
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    Downtown Durham Office Space Available
    $29 SF/Yr
    32,522 SF

    Downtown Durham Office Space Available

    Move-in ready office space in downtown Durham with modern amenities.

    505 S Duke St, Durham, NC 27701
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    Roxboro Road Professional Office Space
    $20 SF/Yr
    2,408 SF

    Roxboro Road Professional Office Space

    Office space ideal for professional services and medical offices.

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704
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    Downtown Durham Office Space Available
    $32 SF/Yr
    25,678 SF

    Downtown Durham Office Space Available

    Suites available in historic Art Deco building, downtown Durham.

    331 W Main Street, Durham, NC 27707
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    Luxury Mixed-Use Development Near Duke
    $25 SF/Yr
    118,000 SF

    Luxury Mixed-Use Development Near Duke

    Class A mixed-use development near Duke University and hospitals.

    2812 & 2816 Erwin Rd |, Durham, NC 27705
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    Office Space Near Universities
    $1,995/Mo
    1,000 SF

    Office Space Near Universities

    Office space in Durham, close to amenities and universities.

    1804 Martin Luther King Junior Parkway, Durham, NC 27707
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    Research Triangle Park, NC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Research Triangle Park, NC with 152 listings featured on our commercial real estate exchange. The current inventory includes 713,481 square feet of properties with an estimated lease value of $4,031,788.

    Estimated lease rates for Commercial real estate in Research Triangle Park, NC begin at $5 SF/Yr, with an average of $118,582 and extend to $3,950,000.
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