Brookline, MO Commercial Real Estate for Lease

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12 properties

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Updated: Aug 5

Renovated Office Units

564 U.S. Highway 60 E, Republic, MO 65738

$2,500/Mo

0.33 AC lot

2017 renovation included roof, windows, exterior siding, plumbing, lighting, and HVAC updates
Office layout supports up to 16 desk areas with reception and conference space
Two private offices and two semi‑private offices
Highway 60 frontage with direct access at 564 U.S. Highway 60 E
0.33‑acre property with exterior storage shed

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Updated: Dec 2, 2025

Duplex Office Units

871 Us Highway 60 E, Republic, MO 65738

$1,800/Mo

0.20 AC lot

Duplex office property with reception area and lobby
Private office, bathroom, and two open rooms for flexible use
0.2‑acre site at 871 US Highway 60 E, Republic, MO 65738
Zoned INC
Central Air, gas cooling, and natural gas heating

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US-60 Endcap Retail/Service Space

411 Us Highway 60 E, Republic, MO 65738

$18 SF/Yr

4,800 sqft

Endcap space with multiple direct US-60 access points and potential drive-thru opportunity on a busy commercial corridor.

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Prime Retail Space in Republic

2510-2544 S. State Hwy MM, Republic, MO 65738

$18 SF/Yr

24,000 sqft

Retail spaces available in a high-growth Republic, MO location.

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Signalized-Corner Strip Mall

533-591 E Elm St 542-590 E Harrison St, Republic, MO 65738

$20 SF/Yr

Established retail center with on-site parking, pylon signage, and access to community amenities.

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Office and Medical Building

975 N Lindsey Ave, Republic, MO 65738

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3,864 sqft

Office and medical space available in Republic with convenient access to US-60 and nearby development.

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Warehouse Space With Dock Doors

3570 E Sawyer Rd, Republic, MO 65619

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25,000 sqft

Industrial leasing opportunity with loading access, three-phase power, and an NNN lease structure.

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2024 Warehouse with Office

2958 US-60, Republic, MO 65738

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24,000 sqft

Newly built 24,000 SF warehouse for lease with a 1,300 SF office buildout and two dock doors.

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Prime Commercial Land for Lease

1600 U.S. 60, Republic, MO 65738

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1 sqft

Exceptional property with high visibility and easy access.

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Republic Office Space For Rent

201-267 W US Hwy 60, Republic, MO

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1,394 sqft 3.16 AC lot

Office spaces available, ranging from 127 to 1,606 SF.

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Republic Industrial Building For Lease

3135 Hankins Road, Republic, MO 65619

$7.50 SF/Yr

52,120 sqft

52,120 SF industrial building in Republic, Missouri available October 2025.

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Republic Industrial Building For Lease

3130 E Hankins Rd, Republic, MO 65738

$7.25 SF/Yr

75,160 SF industrial building in Republic, Missouri.

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Based on your search, we've compiled 108 Potential Opportunities for your consideration. Besides 12 Active listings in Brookline, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 92 Properties for Sales.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Retail Suite with Multiple Entry Points

3202 W. Republic Rd, Springfield, MO 65807

$16 SF/Yr

Two workrooms, a private office, storage, restrooms, and parking support a flexible commercial layout.

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Retail Space at Signalized Intersection

3535 W Sunshine St, Springfield, MO 65807

$23.68 SF/Yr

Retail space available at a high-traffic, anchored location.

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Retail Endcap with Drive-Through

4100 Wilson Creek Marketplace Road, Battlefield, MO 65619

$30 SF/Yr

1.24 AC lot

New C-2 retail space is planned for white-box delivery at a signalized intersection.

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Retail Endcap with Drive-Through

4100 Wilson Creek Marketplace Road, Battlefield, MO 65619

$24 SF/Yr

1.24 AC lot

New C-2 retail construction offered in white-box condition at a signalized intersection.

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Similar Spaces for Sale in Brookline, MO

Consider Similar Space for Sale. We found 92 Spaces matching your search parameters.

Industrial/Service Development Land

2756 N, Brookline, MO 65619

$335,000

1,200 sqft 1.05 AC lot

Development land across from an Amazon distribution center with utilities nearby for restaurant, service, or small industrial use.

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Renovated Office Units

564 Us Highway 60 E, Republic, MO 65738

$350,000

0.33 AC lot

Highway 60 frontage, flexible work areas, and a 2017 renovation support a range of established office configurations.

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Republic MO Office Building For Sale

209-213 North Main Street, Republic, MO 65738

$415,000

6,491 sqft

Office building with multiple offices, conference room, and parking.

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General Retail Development Lot

1397 E US-60, Republic, MO 65738

$649,000

1.61 AC lot

Shovel-ready General Retail zoned lot with utilities on site and direct access via an inserted street for retail development.

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Commercial Land with Highway Frontage

2513 South State Highway MM, Republic, MO 65738

$1,037,000

3.40 AC lot

Development lot with Highway MM frontage and signalized intersection access near an Amazon fulfillment center.

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Office and Medical Building

975 N Lindsey Ave, Republic, MO 65738

Contact for pricing

3,864 sqft

Versatile office building near US-60 in Republic, suited for office, medical, or professional service users.

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Gym With Retractable Basketball Goals

931 N Walnut Avenue, Republic, MO 65738

$1,200,000

0.69 AC lot

Flexible sports facility with batting cages, offices, restrooms, storage, and controlled keypad entry.

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Republic Commercial Land For Sale

3001 East Sawyer Road, Republic, MO 65738

$777,000

4.46 AC lot

Development lots available next to Amazon Fulfillment Center.

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Commercial Land Across From Amazon

2756 N Brookline Avenue, Republic, MO 65619

$335,000

1.05 AC lot

One-acre tract with water and sewer lines along the property.

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Commercial Land with Freeway Frontage

6140 W Farm Road 156, Republic, MO 65738

$1,500,000

86.60 AC lot

Large commercial tract with Farm Road 156 access and electricity available.

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Highway-Frontage Commercial Land

6140 W Farm Road 156, Republic, MO 65738

$1,500,000

86.60 AC lot

AG-zoned tract with blacktop access from Farm Road 156.

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Commercial Development Land Parcel

825 E Colter Drive # Lot 10, Republic, MO 65738

$124,000

1.00 AC lot

Vacant commercial lot with convenient access near the main commercial district off US-60 and Hwy 174.

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Brookline, MO Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in Brookline, MO with 12 listings featured on our commercial real estate exchange. The current inventory includes 135,179 square feet of properties with an estimated lease value of $70.75.

Estimated lease rates for Commercial real estate in Brookline, MO begin at $7.25 SF/Yr, with an average of $14.15 SF/Yr and extend to $20 SF/Yr.

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