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    Brookline, MO

    Brookline, MO Commercial Real Estate for Lease

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    14 properties
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    Office Duplex with Open Work Areas
    Updated: Dec 2, 2025
    Office Duplex with Open Work Areas

    871 Us Highway 60 E, Republic, MO 65738

    $1,800/Mo
    Commercial duplex space in Republic with a professional layout featuring a front desk/reception and lobby
    Includes a private office, bathroom, and two open areas for workstations or conference space
    Central air with natural gas heating and gas cooling
    Driveway parking
    Composition roof; built in 1986
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    US-60 Endcap Retail/Service Space
    Updated: Jul 26
    US-60 Endcap Retail/Service Space

    411 Us Highway 60 E, Republic, MO 65738

    $18 SF/Yr
    4,800 sqft
    Endcap retail/office/service space +/- 4,800 SF at 411‑417 US‑60
    Multiple direct access points from US‑60 for convenient customer entry
    Western endcap offers potential drive‑thru opportunity
    On US‑60 directly west of TR Fitness and Domino's
    Year built 1980
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    Prime Retail Space in Republic
    Prime Retail Space in Republic

    2510-2544 S. State Hwy MM, Republic, MO 65738

    $18 SF/Yr
    24,000 sqft

    Retail spaces available in a high-growth Republic, MO location.

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    Retail/Office Suite with Open Layout
    Retail/Office Suite with Open Layout

    201-267 W US Hwy 60, Republic, MO 65738

    Contact for pricing
    2,750 sqft

    Mostly wide-open former martial arts suite available in a retail/office center with C-1 zoning and prominent Hwy 60 access.

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    2024 Warehouse with Office
    2024 Warehouse with Office

    2958 US-60, Republic, MO 65738

    Contact for pricing
    24,000 sqft

    Newly built 24,000 SF warehouse for lease with a 1,300 SF office buildout and two dock doors.

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    Office and Medical Building
    Office and Medical Building

    975 N Lindsey Ave, Republic, MO 65738

    Contact for pricing

    Office and medical space available in Republic with convenient access to US-60 and nearby development.

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    Republic Office Space For Rent
    Republic Office Space For Rent

    201-267 W US Hwy 60, Republic, MO

    Contact for pricing
    1,394 sqft

    Office spaces available, ranging from 127 to 1,606 SF.

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    Retail Suite with Utilities Included
    Retail Suite with Utilities Included

    201-267 W US Hwy 60, Republic, MO 65738

    Contact for pricing
    1,313 sqft

    Multiple retail-office suites are available in a C-1 shopping center with gas, water, and electric included.

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    Republic Industrial Building For Lease
    Republic Industrial Building For Lease

    3135 Hankins Road, Republic, MO 65619

    $8 SF/Yr
    52,120 sqft

    52,120 SF industrial building in Republic, Missouri available October 2025.

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    Republic Industrial Building For Lease
    Republic Industrial Building For Lease

    3130 E Hankins Rd, Republic, MO 65738

    $7.75 SF/Yr

    75,160 SF industrial building in Republic, Missouri.

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    Prime Commercial Land for Lease
    Prime Commercial Land for Lease

    1600 U.S. 60, Republic, MO 65738

    Contact for pricing
    1 sqft

    Exceptional property with high visibility and easy access.

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    Prime Commercial Space For Lease
    Prime Commercial Space For Lease

    542 E Harrison St, Republic, MO 65738

    Contact for pricing

    Commercial property for lease with high visibility and ample parking.

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    Republic Industrial Building For Lease
    Republic Industrial Building For Lease

    3135 E Hankins Rd, Republic, MO 65738

    Contact for pricing
    52,120 sqft

    Industrial building for lease in Republic, Missouri, available October 2025.

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    Retail Pad Site For Lease
    Retail Pad Site For Lease

    Republic, 1355 US Hwy 60, Republic, MO 65738

    Contact for pricing

    Land lease opportunity next to future Andy's Frozen Custard.

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    Based on your search, we've compiled 119 Potential Opportunities for your consideration. Besides 14 Active listings in Brookline, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 101 Properties for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Shop Building with Land
    Shop Building with Land

    4011 State Highway Zz, Billings, MO 65610

    $1,000/Mo

    Commercial shop building with land available for lease.

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    New Industrial Space For Rent
    New Industrial Space For Rent

    2851 US Hwy 60 N, Billings, MO

    Contact for pricing
    2,000 sqft

    New industrial property for rent, completion estimated October 2025.

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    Retail Endcap with Drive-Through
    Retail Endcap with Drive-Through

    4100 Wilson Creek Marketplace Road, Battlefield, MO 65619

    $24 SF/Yr

    Newly planned endcap retail suite with drive-through option for QSR use in a retail-focused C-2 development.

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    Retail Endcap with Drive-Through
    Retail Endcap with Drive-Through

    4100 Wilson Creek Marketplace Road, Battlefield, MO 65619

    $30 SF/Yr

    New retail endcap with drive-through is being built as a white-box suite in a multi-tenant development.

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    Similar Spaces for Sale in Brookline, MO

    Consider Similar Space for Sale. We found 101 Spaces matching your search parameters.

    Prime Commercial Land Opportunity
    Prime Commercial Land Opportunity

    2756 N Brookline Avenue, Republic, MO 65619

    $335,000
    1,200 sqft 1.05 AC lot

    1.05 acre commercial land across from Amazon Distribution Center.

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    Industrial/Service Development Land
    Industrial/Service Development Land

    2756 N, Brookline, MO 65619

    $335,000
    1,200 sqft 1.05 AC lot

    Development land across from an Amazon distribution center with utilities nearby for restaurant, service, or small industrial use.

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    Republic MO Office Building For Sale
    Republic MO Office Building For Sale

    209-213 North Main Street, Republic, MO 65738

    $415,000
    6,491 sqft

    Office building with multiple offices, conference room, and parking.

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    General Retail Development Lot
    General Retail Development Lot

    1397 E US-60, Republic, MO 65738

    $649,000
    1.61 AC lot

    Shovel-ready General Retail zoned lot with utilities on site and direct access via an inserted street for retail development.

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    Commercial Land with Highway Frontage
    Commercial Land with Highway Frontage

    2513 South State Highway MM, Republic, MO 65738

    $1,037,000
    3.40 AC lot

    Development lot with Highway MM frontage and signalized intersection access near an Amazon fulfillment center.

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    Commercial Land Across From Amazon
    Commercial Land Across From Amazon

    2756 N Brookline Avenue, Republic, MO 65619

    $335,000
    1.05 AC lot

    1.05+/- acre commercial tract in R1 zoning with water and sewer lines along the property and an existing house included no value.

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    High Visibility Republic Land Tract
    High Visibility Republic Land Tract

    6140 W Farm Road 156, Republic, MO 65738

    $1,500,000
    86.60 AC lot

    Large tract in a rapidly developing area near Springfield, MO.

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    High Visibility Land in Republic
    High Visibility Land in Republic

    6140 W Farm Road 156, Republic, MO 65738

    $1,500,000
    86.60 AC lot

    Large tract in a rapidly developing area near Springfield, MO.

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    Commercial Development Land Parcel
    Commercial Development Land Parcel

    825 E Colter Drive # Lot 10, Republic, MO 65738

    $124,000
    1.00 AC lot

    Vacant commercial lot with convenient access near the main commercial district off US-60 and Hwy 174.

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    Highway Frontage Commercial Lot
    Highway Frontage Commercial Lot

    U.S. Highway 60 E, Republic, MO 65738

    $419,000
    0.94 AC lot

    Prime commercial lot on Highway 60 in Republic, Missouri.

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    Brookline, MO Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Brookline, MO with 14 listings featured on our commercial real estate exchange. The current inventory includes 80,920 square feet of properties with an estimated lease value of $44 SF/Yr.

    Estimated lease rates for Commercial real estate in Brookline, MO begin at $8 SF/Yr, with an average of $14.67 SF/Yr and extend to $18 SF/Yr.
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    Most Searched ZIP Codes in Brookline, MO

    • 65738
    • 65619

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