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    Columbia, IL Commercial Real Estate for Lease

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    Dupo, IL Saint Louis, MO Waterloo, IL Arnold, MO Millstadt, IL Mehlville, MO Imperial, MO Cahokia, IL
    7 properties
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    Build-to-Suit Retail Space
    Updated: Jun 11
    Build-to-Suit Retail Space

    548 S Main Street, Columbia, IL 62236

    $2,000/Mo
    Commercial space for lease at 548 S Main St in Columbia
    Lease rate listed as $20/sf (list price reflects a 1,200 SF lease)
    Built‑to‑suit main‑level space range: 1,000 to 3,500 SF, with potential for up to four individual units
    Minimum lease requirement is 800 SF
    Owner pays utilities; water source is public
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    Basement Office Unit with Utilities Included
    Updated: Nov 17, 2025
    Basement Office Unit with Utilities Included

    207 N Main Basement Unit B Street N, Columbia, IL 62236

    $525/Mo
    14,000 sqft
    Basement office unit B in a brick commercial building
    Water, sewer, trash, and heating/cooling included in rent
    One‑year lease term
    Forced air heating plus central air cooling
    Property on 0.41‑acre lot with 14,000 SF building
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    Retail Storefront Space
    Retail Storefront Space

    548 S Main Street, Columbia, IL 62236

    $2,000/Mo

    Storefront retail space available for rent with GPS-friendly directions in Monroe County.

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    Commercial Land with Drive-Through
    Commercial Land with Drive-Through

    310 Southport Dr, Columbia, IL 62236

    Contact for pricing
    1 sqft 1.00 AC lot

    Commercial development site with drive-through capabilities and dedicated access.

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    Office Suite with Kitchenette
    Office Suite with Kitchenette

    280 Southwoods Ctr, Columbia, IL 62236

    $1,250/Mo
    1,000 sqft

    Two private offices and a spacious main area create a practical professional workspace.

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    Move-in Ready Suites For Lease
    Move-in Ready Suites For Lease

    302-306 Southport Dr, Columbia, IL

    Contact for pricing
    1,525 sqft 4.56 AC lot

    Premium suites suitable for retail, office, or medical applications.

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    Move-in Ready Suites For Lease
    Move-in Ready Suites For Lease

    310-314 Southport Dr, Columbia, IL

    Contact for pricing
    1,525 sqft 4.56 AC lot

    Premium suites suitable for retail, office, or medical applications.

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    Based on your search, we've compiled 29 Potential Opportunities for your consideration. Besides 7 Active listings in Columbia, IL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 18 Properties for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Modern Warehouse with Tool Room
    Modern Warehouse with Tool Room

    1059 S JEFFERSON ST, Millstadt, IL 62260

    Contact for pricing
    4,000 sqft

    4,000 SF rebuilt 2026 warehouse offers 16' clear height, reinforced 6" concrete floor, and overhead doors with bathroom roughed-in.

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    Rebuilt Warehouse with Reinforced Floor
    Rebuilt Warehouse with Reinforced Floor

    1055 S Jefferson St, Millstadt, IL 62260

    Contact for pricing
    4,000 sqft

    4,000 SF rebuilt warehouse with 16' clear height, reinforced concrete floor, and two overhead doors.

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    Flex Space with Off-Street Parking
    Flex Space with Off-Street Parking

    2627 Telegraph Rd, Saint Louis, MO 63125

    $600/Mo

    Flex space available for lease with off-street parking.

    View details
    Retail Space in St. Louis
    Retail Space in St. Louis

    Saint Louis, MO 63129

    Contact for pricing

    Retail spaces available in South County Center, St. Louis.

    View details

    Similar Spaces for Sale in Columbia, IL

    Consider Similar Space for Sale. We found 18 Spaces matching your search parameters.

    Brick Mixed-Use Building
    Brick Mixed-Use Building

    123 S Main St, Columbia, IL 62236

    $425,000
    1,500 sqft

    Flexible commercial space with a bar, prep kitchen, basement storage, and two apartments.

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    New Corner Retail Building
    New Corner Retail Building

    548 S Main St, Columbia, IL 62236

    $250,000
    3,500 sqft

    To-be-built corner retail structure with flexible main-level configuration up to four units.

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    Versatile Commercial Condo For Sale
    Versatile Commercial Condo For Sale

    284 Southwoods Ctr, Columbia, IL 62236

    $115,000
    900 sqft

    900 SF commercial condo, tenant occupied, great investment opportunity.

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    Highway-Visible Commercial Land
    Highway-Visible Commercial Land

    310 Southport Dr, Columbia, IL 62236

    Contact for pricing
    1 sqft 1.00 AC lot

    One-acre commercial site with dedicated access and drive-through capabilities integrated into the planned development layout.

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    Newly Renovated Downtown Commercial Building
    Newly Renovated Downtown Commercial Building

    216 N Main St, Columbia, IL 62236

    $1,500,000

    Newly renovated commercial building with a new roof, HVAC, and electrical system throughout.

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    Two-Parcel Historic Tavern Property
    Two-Parcel Historic Tavern Property

    316/318 N Main St, Columbia, IL 62236

    $850,000

    Historic two-building package with a two-level tavern building and a 1850s structure on separate parcels.

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    Event and Banquet Venue
    Event and Banquet Venue

    300 Admiral Weinel Blvd, Columbia, IL 62236

    $3,500,000

    Versatile event venue with banquet rooms, commercial kitchen, walk-in freezer, and soundproof studios.

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    Commercial Development Site with Corner Location
    Commercial Development Site with Corner Location

    548 S Main Street, Columbia, IL 62236

    $250,000

    Corner development site with planned main-level commercial space fronting Main Street and the GM&O Trail.

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    Commercial Development Lot with Visibility
    Commercial Development Lot with Visibility

    5 Hill Castle Ln, Columbia, IL 62236

    Contact for pricing
    0.48 AC lot

    Zoned C3 with 135 feet of frontage and Route 3 visibility, plus concept plans for a small commercial building.

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    Tenant-Occupied Office Condo
    Tenant-Occupied Office Condo

    282 Southwoods Drive, Columbia, IL 62236

    $115,000
    0.88 AC lot

    Well-maintained 900 sf office condo with private half bath and functional layout, currently tenant occupied.

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    Tenant-Occupied Office Condo
    Tenant-Occupied Office Condo

    284 Southwoods Drive, Columbia, IL 62236

    $115,000
    0.88 AC lot

    Well-maintained office condo with a functional layout and half bath, currently tenant occupied.

    View details
    Commercial Land with Drive-Through Design
    Commercial Land with Drive-Through Design

    310 Southport Drive, Columbia, IL 62236

    Contact for pricing

    Commercial-zoned development site configured for drive-through use and build-to-suit projects.

    View details
    Newly Renovated Main Street Retail Building
    Newly Renovated Main Street Retail Building

    218 N Main St, Columbia, IL 62236

    Contact for pricing

    Newly renovated downtown retail building with updated roof, HVAC, electrical, ceilings, and flooring.

    View details
    Brick Office Condo with Half Bath
    Brick Office Condo with Half Bath

    272 Southwoods Drive, Columbia, IL 62236

    $115,000
    0.88 AC lot

    Well-maintained brick office condo with central air and forced-air electric heat, plus a half bathroom.

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    Single-Tenant Drugstore Leasehold
    Single-Tenant Drugstore Leasehold

    100 Admiral Weinel Blvd, Columbia, IL 62236

    Contact for pricing

    Single-tenant Walgreens property on a double net lease with roughly 11.75 years remaining and multiple 5-year options.

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    Two-Tenant Medical Office Building
    Two-Tenant Medical Office Building

    200 Admiral Trost Dr, Columbia, IL 62236

    Contact for pricing

    Two-tenant medical office building with multiple healthcare occupants and tenant improvements support.

    View details
    1.21 Acre Site on Route 3
    1.21 Acre Site on Route 3

    100 Southwoods Ctr, Columbia, IL

    Contact for pricing
    1.21 AC lot

    1.21 acre commercial land with C3 zoning on Route 3.

    View details

    Columbia, IL Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Columbia, IL with 7 listings featured on our commercial real estate exchange. The current inventory includes 18,051 square feet of properties with an estimated lease value of $15.

    Estimated lease rates for Commercial real estate in Columbia, IL average $15 SF/Yr.
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