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Safety Harbor, FL Commercial Real Estate for Lease

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Downtown Safety Harbor Mixed-Use Space
$4,750 / Mo
2,975 SF

Downtown Safety Harbor Mixed-Use Space

125 5Th Ave N, Safety Harbor, FL 34695

Move-in ready office, retail, and live-in co-work space.

  • Prime location in vibrant Downtown Safety Harbor on 5th and Main Street with excellent frontage and visibility.
  • Versatile space suitable for office, retail, live‑in, co‑work, or short‑term rental/B&B with a wide range of allowable business uses.
  • Move‑in ready with renovated full‑size kitchen (stainless steel appliances), chic bathroom finishes, and new porcelain floor tile throughout.
  • Open concept split plan with 3 bedrooms and 2 full bathrooms spanning 1,456 square feet.
  • Walking distance to parks, shops, fine dining, marina, and the Safety Harbor Resort and Spa.
Updated: Jan 14
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Safety Harbor Office Space Available
$20 SF/Yr
3,650 SF

Safety Harbor Office Space Available

701 Enterprise Rd E, Safety Harbor, FL 34695

Stand-alone office space in Safety Harbor available for lease.

  • 3,650sf stand‑alone office space suitable for medical, professional, or creative use.
  • Budget‑friendly modified gross lease with no NNN fees (tenant pays utilities).
  • Abundant parking and convenient location near downtown Safety Harbor, Philippe Park, and McMullen Booth Rd retail.
  • Features individual office spaces, conference rooms, open team areas, kitchen, and a shower.
  • Three ADA restrooms and 100% air‑conditioned.
Updated: Sep 5, 2025
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Safety Harbor Office Space Available
$34 SF/Yr
3,498 SF

Safety Harbor Office Space Available

Office suites available for lease in Safety Harbor, Florida.

670 2Nd St N, Safety Harbor, FL 34695
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Prime Safety Harbor Retail Space
Contact for pricing
28,000 SF

Prime Safety Harbor Retail Space

Brand New, 28,000 SF Retail Building

1885 Cedar St, Safety Harbor, FL 34695
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Based on your search, we've compiled 14 Potential Opportunities for your consideration. Besides 4 Active listings in Safety Harbor, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

Explore Commercial Real Estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Northwood Commons Retail Space
Contact for pricing
28,015 SF

Northwood Commons Retail Space

Clearwater retail center, prime location.

2454 Mcmullen Booth Rd, Clearwater, FL 33759
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Clearwater Medical Office Space Available
$22 SF/Yr
1,869 SF

Clearwater Medical Office Space Available

Garden-style office unit for lease in Hidden Oaks Professional Park.

1700 Mcmullen Booth Rd, Clearwater, FL 33759
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Industrial Space Available For Sublease
Contact for pricing
85,000 SF

Industrial Space Available For Sublease

Sublease opportunity with subdivision potential and air conditioning.

375 Mears Blvd, Oldsmar, FL 34677
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Retail Space on Tampa Road
$19 SF/Yr
900 SF

Retail Space on Tampa Road

Retail space available for rent on Tampa Road, Oldsmar, FL.

3780 Tampa Rd, Oldsmar, FL 34677
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Explore Similar Spaces for Sale in Safety Harbor, FL

Consider Similar Space for Sale. We found 6 Spaces in Nearby Locations matching your search parameters.

Established Motel with Redevelopment Potential
$2,047,000
3,106 SF

Established Motel with Redevelopment Potential

8-unit motel on 1.54 acres, prime location, redevelopment opportunity.

3110 Philippe Pkwy, Safety Harbor, FL 34695
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Historic Mixed-Use Property on Main
Pending
$3,999,000
9,605 SF

Historic Mixed-Use Property on Main

Charming mixed-use property in Safety Harbor's vibrant downtown.

454 Main St, Safety Harbor, FL 34695
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Safety Harbor Mixed-Use Opportunity
$1,625,000
3,825 SF

Safety Harbor Mixed-Use Opportunity

Versatile property near downtown Safety Harbor with development potential.

1055 Philippe Pkwy, Safety Harbor, FL 34695
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Functional Office Building Near Main
$1,299,000
3,812 SF

Functional Office Building Near Main

Professional office building in downtown Safety Harbor, steps from Main.

108 4Th Ave S, Safety Harbor, FL 34695
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Profitable Marble and Granite Workshop
$99,500
12,680 SF

Profitable Marble and Granite Workshop

Turnkey marble and granite workshop in Safety Harbor, Florida.

Address Undisclosed Ct, Safety Harbor, FL 34695
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Safety Harbor Mixed-Use Property
$1,873,500
3,895 SF

Safety Harbor Mixed-Use Property

Prime location, endless possibilities. $1.87M

1055 Philippe Pkwy, Safety Harbor, FL 34695
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Safety Harbor, FL Commercial Real Estate Leasing Opportunities Market Analysis

Explore Commercial Real Estate leasing options in Safety Harbor, FL with 10 listings featured on our commercial real estate exchange. The current inventory includes 440,957,880 square feet of properties with an estimated lease value of $74 SF/Yr.

Estimated lease rates for Commercial Real Estate in Safety Harbor, FL begin at $20 SF/Yr, with an average of $24 SF/Yr and extend to $34 SF/Yr.

In Safety Harbor, FL, current lease rates show:

  • Office Properties & Spaces positioned at $24
  • Office space measuring $27
  • Individual retail properties assessed at $20
  • Medical offices calculated at $20
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