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    Hannibal, MO Bed & Breakfasts for Sale

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    Historic Landmark Estate and Venue
    $2,400,000
    9,021 SF

    Historic Landmark Estate and Venue

    11069 New London Gravel Rd, Hannibal, MO 63401

    36-acre Victorian estate with ties to Mark Twain.

    • Historical Significance: Landmark estate with direct ties to Mark Twain, offering a unique opportunity to own a piece of American literary history.
    • Turn‑Key Business Opportunity: Established and acclaimed bed & breakfast and wedding venue with international name recognition and income‑generating cottages.
    • Expansive Estate: 36 acres of manicured lawns, rolling pastures, and wooded privacy, providing a serene and picturesque setting.
    • Authentic Victorian Features: Original hand‑carved walnut woodwork, marble fireplaces, light fixtures, and furnishings, preserving the mansion's 19th‑century charm.
    • Multiple Accommodation Options: 17 total bedrooms, most with private ensuite bathrooms, suitable for various uses including a private residence, corporate retreat, or family compound.
    Updated: Mar 5
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    Remodeled Building in Downtown Hannibal
    $1,850,000
    14,638 SF

    Remodeled Building in Downtown Hannibal

    408 N Main St, Hannibal, MO 63401

    Renovated building with Airbnb units and bar areas.

    • Prime downtown corner location with high traffic, across from the Mark Twain Museum
    • Significant remodel completed 2022‑2024 by Bleigh Construction, enhancing the building's value
    • Two fully equipped Airbnb/VRBO units on the upper level
    • Two bars (one upstairs, one at the front) and a fully equipped kitchen
    • Roll‑up garage‑style doors opening to an outdoor patio
    Updated: Nov 17, 2025
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    Based on your search, we've compiled 6 Potential Opportunities for your consideration. Besides 2 Active listings in Hannibal, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Grafton Bed & Breakfast Opportunity
    $2,700,000
    4,800 SF

    Grafton Bed & Breakfast Opportunity

    Bed & breakfast with stunning river views and growth potential.

    1 Tara Point Dr, Grafton, IL 62037
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    Grafton Commercial Property on Main
    $429,000
    1,600 SF

    Grafton Commercial Property on Main

    Turn-key commercial property on Main Street in Grafton, Illinois.

    222 E Main St, Grafton, IL 62037
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    Katy Trail Hospitality Opportunity
    Contact for pricing

    Katy Trail Hospitality Opportunity

    Unique property with multiple income streams on the Katy Trail.

    112 Defiance Rd, Defiance, MO 63341
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    Katy Trail Hospitality Opportunity
    Contact for pricing

    Katy Trail Hospitality Opportunity

    Unique property with multiple income streams on the Katy Trail.

    100 Defiance Rd, Defiance, MO 63341
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    Hannibal, MO Bed & Breakfasts Investment Opportunities Market Analysis

    Explore 2 bed & breakfasts for sale in Hannibal, MO on our real estate platform. These investment opportunities span a total of 1,592,989 square feet of properties for sale, with an estimated market value of $4,250,000.

    Sale prices for inns in Hannibal, MO start at $1,850,000, averaging $2,125,000, and reaching up to $2,400,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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