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Frederick, MD Office Units for Lease

53 results
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Frederick Commercial Space with Drive-Through
$18 SF/Yr

Frederick Commercial Space with Drive-Through

198 THOMAS JOHNSON Drive unit: 207, Frederick, MD 21701

Versatile commercial space in Frederick, ideal for various businesses.

  • High‑visibility location in Frederick City with heavy traffic flow.
  • Versatile +/- 1,890sf space suitable for various businesses.
  • Benefit from Drive‑through access (formerly a bank).
  • ADA accessibility with main‑level ramp.
  • Large parking lot.
Updated: Nov 9, 2025
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Charming Frederick Office Space Available
$800 /Mo

Charming Frederick Office Space Available

3390 URBANA Pike unit: Suite 2, Frederick, MD 21704

Sophisticated office space in a character-rich building with parking.

  • Prime location with strategic accessibility and prestigious community presence.
  • Dedicated parking lot for convenient client and employee parking.
  • High ceilings and abundant natural light create an uplifting and inspiring workspace.
  • Opportunity to create a bespoke interior space tailored to specific business needs.
  • Charming, character‑rich building with a professional and welcoming atmosphere.
Updated: Dec 11, 2025
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Frederick Commercial Space with Drive-Through
$18 SF/Yr

Frederick Commercial Space with Drive-Through

Versatile commercial space in Frederick, ideal for various businesses.

198 THOMAS JOHNSON Drive unit: 205-206, Frederick, MD 21701
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Frederick Commercial Space For Lease
$18 SF/Yr

Frederick Commercial Space For Lease

Highly visible commercial space with ADA access and ample parking.

198 THOMAS JOHNSON Drive unit: 8, Frederick, MD 21701
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Downtown Frederick Office Space
$20 SF/Yr

Downtown Frederick Office Space

Charming office building in historic Downtown Frederick.

22 SECOND Street E, Frederick, MD 21701
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Charming Frederick Office Space Available
$800 /Mo

Charming Frederick Office Space Available

Sophisticated office space in a character-rich building with negotiable lease.

3390 URBANA Pike unit: Suite 4, Frederick, MD 21704
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Charming Frederick Office Space Available
$800 /Mo

Charming Frederick Office Space Available

Exquisite commercial lease opportunity with historic elegance and modern functionality.

3390 URBANA Pike unit: Suite 3, Frederick, MD 21704
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Office Space in Frederick, MD
$2,120 /Mo

Office Space in Frederick, MD

Office space available for lease in Frederick, Maryland.

6550 MERCANTILE Drive E unit: 105, Frederick, MD 21703
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Charming Frederick Office Space Available
$800 /Mo

Charming Frederick Office Space Available

Sophisticated office space in a character-rich building with negotiable lease.

3390 URBANA Pike unit: Suite 1, Frederick, MD 21704
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Frederick Commercial Space with Drive-Through
$18 SF/Yr

Frederick Commercial Space with Drive-Through

Versatile commercial space in Frederick, ideal for various businesses.

198 THOMAS JOHNSON Drive unit: 1,2, Frederick, MD 21701
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Ambers Professional Center Office Space
$17 SF/Yr
3,000 SF

Ambers Professional Center Office Space

Office suites available in Frederick, ranging from 400-3,000 sqft.

178 THOMAS JOHNSON Dr SUITE 100, Frederick, MD 21702
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Charming Cottage for Commercial Leasing
$1,200 /Mo

Charming Cottage for Commercial Leasing

Standalone cottage blending historic character with modern comfort, ideal for professionals.

3390 Urbana #cottage, Frederick, MD 21704
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Commercial/Medical Office Space Available
$16 SF/Yr
9,000 SF

Commercial/Medical Office Space Available

Commercial/medical office space for lease, convenient location, remodeling options.

46 Thomas Johnson Dr, Frederick, MD 21702
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Thomas Johnson Drive Office Space
$18 SF/Yr
7,844 SF

Thomas Johnson Drive Office Space

7,844± SF of professional office space for lease.

70 Thomas Johnson Dr, Frederick, MD
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Downtown Frederick Flex/Warehouse Space
$7 SF/Yr
7,268 SF

Downtown Frederick Flex/Warehouse Space

Flex/warehouse space near I-70 and Frederick Municipal Airport.

215 E 8th St, Frederick, MD
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Urbana Pike Retail/Office Space
$3,875 /Mo

Urbana Pike Retail/Office Space

Professional suites off 355 in Urbana, available in 2023.

3535 URBANA Pike unit: 201, Frederick, MD 21704
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Office/Warehouse Flex Space Available
$33 SF/Yr
4,694 SF

Office/Warehouse Flex Space Available

Office space with small warehouse component for rent.

5310 Spectrum Dr, Frederick, MD
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Downtown Frederick Office Space
$15 SF/Yr
3,030 SF

Downtown Frederick Office Space

Office space in downtown Frederick, walking distance to amenities.

116-120 E 2nd St, Frederick, MD
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Office Space for Rent
Contact for pricing

Office Space for Rent

Office space available for lease in Frederick, Maryland.

5285 Westview Drive, Frederick, MD 21703
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Flex Space Near Biotech Hub
Contact for pricing
38,120 SF

Flex Space Near Biotech Hub

Flex/R&D space in Frederick County near key institutions.

424 Mohican Dr, Frederick, MD
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Frederick Flex/R&D Space Available
Contact for pricing
38,120 SF

Frederick Flex/R&D Space Available

Flex/R&D space in Frederick's biotech hub.

436 Mohican Dr, Frederick, MD
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Flex Space Near Biotech Hub
Contact for pricing
38,120 SF

Flex Space Near Biotech Hub

Flex/R&D space ideal for biotech, office, warehouse, distribution.

430 Mohican Dr, Frederick, MD
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Urbana Pike Retail/Office Space
$5,935 /Mo

Urbana Pike Retail/Office Space

Retail and office suites available for lease in Frederick, MD.

3535 URBANA Pike unit: 101, Frederick, MD 21704
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Frederick Office Space For Rent
$12 SF/Yr
19,121 SF

Frederick Office Space For Rent

19,121 square foot office space available for lease.

7430 Technology Way, Frederick, MD
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Frederick, MD Office Units Leasing Opportunities Market Analysis

Explore Office Units leasing options in Frederick, MD with 53 listings featured on our commercial real estate exchange. The current inventory includes 25,446,149,538 square feet of properties with an estimated lease value of $131 SF/Yr.

Estimated lease rates for Office Units in Frederick, MD begin at $2 SF/Yr, with an average of $14 SF/Yr and extend to $20 SF/Yr.
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