Panama City, FL Office space for Rent & Lease

$21 SF/Yr

1,906 SF

Downtown Panama City Office Space

455 Harrison Ave, Panama City, FL 32401

Professional office space in downtown Panama City for lease.

Prime Downtown Panama City location on Harrison Avenue.
1906 sq ft of professional office space.
Well‑maintained: Rebuilt in the early 2000s and consistently occupied since.
Includes a large executive office, two senior level offices, three staff offices, and a conference room.
Features two accessible bathrooms and a breakroom.

Updated: Feb 12

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$2,500 / Mo

1,903 SF

Panama City Office Space Available

309 E 7Th St, Panama City, FL 32401

Well-located office building ideal for small businesses or professional services.

Ready for immediate occupancy, allowing for a quick business setup.
Ideal for various business types: small businesses, medical, or professional services.
Functional layout includes 4 private offices, reception area, full bathroom, and kitchen/break area.
Convenient location with easy access to major roads, local businesses, and amenities.
Clean and modern office building.

Updated: Dec 21, 2025

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$4,000 / Mo

8,376 SF

Downtown Panama City Commercial Space

Rare 3,000 SF commercial space for lease on Harrison Ave.

602 Harrison Ave, Panama City, FL 32401

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$3,500 / Mo

6,500 SF

Versatile Commercial Space Off Highway

Flexible leasing options near Highway 231, ideal for various businesses.

6804 Bayou George Dr, Panama City, FL 32404

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$5,000 / Mo

Versatile Office and Warehouse Space

Versatile office and warehouse space in an ideal location.

1337 W 19Th St, Panama City, FL 32405

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$15 SF/Yr

2,700 SF

Downtown Panama City Commercial Space

Versatile commercial space in historic downtown Panama City with parking.

416 Jenks Ave, Panama City, FL 32401

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$13 SF/Yr

7,200 SF

Panama City Flex Warehouse

7,200 SF flex warehouse in Panama City for lease.

1117 Saint Andrews Blvd, Panama City, FL 32405

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Versatile Multi-Tenant Building For Lease

Contact for pricing

5,000 SF

Versatile Multi-Tenant Building For Lease

Multi-tenant building with flexible space options and strategic location.

501 West 11Th St, Panama City, FL 32401

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$2,500 / Mo

2,000 SF

Remodeled Retail and Office Space

2,000 SF remodeled space suitable for retail or office.

748 E 15Th St, Panama City, FL 32401

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$26 SF/Yr

1,522 SF

Office Space in Town Centre

4,500 SF office suite with multiple offices and amenities.

101 W 5Th St, Panama City, FL 32401

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$10,000 / Mo

15,000 SF

Panama City Office Space

Office space available for lease in Panama City, Florida.

1502 Tennessee Ave, Panama City, FL

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Customizable Office/Flex Space Available

Contact for pricing

7,500 SF

Customizable Office/Flex Space Available

Versatile office/flex space for lease with highway frontage.

2830 Highway 390 East, Panama City, FL 32405

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$20 SF/Yr

9,999 SF

Panama City Office Space

Office space available for lease in Panama City, Florida.

510 N Macarthur Ave, Panama City, FL 32401

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$14 SF/Yr

Flex Building with Office, Warehouse

Flex building featuring office and warehouse space for lease.

7622 Mc Elvey Rd, Panama City, FL 32408

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$1,146 / Mo

24,852 SF

Class A Office Space Available

First floor office space with utilities included, convenient location.

2605 Thomas Dr, Panama City, FL 32408

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$4,800 / Mo

2,310 SF

Medical Office Space Available

Medical office space for rent featuring exam rooms and restrooms.

2101 Northside Dr, Panama City, FL 32405

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$16 SF/Yr

4,845 SF

Functional Office Building For Rent

Professional office building in Panama City's business district.

833 Harrison Ave, Panama City, FL 32401

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$21 SF/Yr

3,255 SF

Spacious Former Doctor's Office

Commercial lease featuring a large lobby and multiple exam rooms.

2316 W 23Rd St, Panama City, FL 32405

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$12 SF/Yr

65,955 SF

Renovated Office Space For Rent

Professional office space with flexible layout in high-visibility location.

615 Highway 231, Panama City, FL 32405

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$4,500 / Mo

3,200 SF

Downtown St Andrews Retail/Office Space

3200 sq ft retail/office space in the heart of St Andrews.

1107 Beck Ave, Panama City, FL 32401

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Contact for pricing

5,000 SF

Commercial Flex Building For Lease

5,000 SF flex building with office and warehouse space.

7622 Mcelvey Rd, Panama City, FL

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Contact for pricing

1,250 SF

New Commercial Building on Navy

New commercial building ideal for retail, office, showroom, and flex.

200 Thomas Dr, Panama City, FL 32408

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$25 SF/Yr

24,852 SF

Class A Office Space Available

First floor office space with utilities included, central location.

2605 Thomas Dr, Panama City, FL 32408

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$19 SF/Yr

8,001 SF

Spacious Medical Office Suite Available

3,250 SF medical office suite for lease.

2428 Jenks Ave, Panama City, FL 32405

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Panama City, FL Office space Leasing Opportunities Market Analysis

Explore Office space leasing options in Panama City, FL with 72 listings featured on our commercial real estate exchange. The current inventory includes 58,011,857,640 square feet of properties with an estimated lease value of $777 /Mo.

Estimated lease rates for Office space in Panama City, FL begin at $0.55 SF/Yr, with an average of $16 SF/Yr and extend to $44 SF/Yr.

Panama City, FL Office Space for Lease

Downtown Panama City Office Space

Professional office space in downtown Panama City for lease.

Panama City Office Space Available

Well-located office building ideal for small businesses or professional services.

Downtown Panama City Commercial Space

Versatile Commercial Space Off Highway

Versatile Office and Warehouse Space

Downtown Panama City Commercial Space

Panama City Flex Warehouse

Versatile Multi-Tenant Building For Lease

Remodeled Retail and Office Space

Office Space in Town Centre

Panama City Office Space

Customizable Office/Flex Space Available

Panama City Office Space

Flex Building with Office, Warehouse

Class A Office Space Available

Medical Office Space Available

Functional Office Building For Rent

Spacious Former Doctor's Office

Renovated Office Space For Rent

Downtown St Andrews Retail/Office Space

Commercial Flex Building For Lease

New Commercial Building on Navy

Class A Office Space Available

Spacious Medical Office Suite Available

Panama City, FL Office space Leasing Opportunities Market Analysis

Browse Office space for Lease Near Panama City, FL

Popular Searches in Panama City, FL

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Panama City, FL Office Space for Lease

Downtown Panama City Office Space

Professional office space in downtown Panama City for lease.

Panama City Office Space Available

Well-located office building ideal for small businesses or professional services.

Downtown Panama City Commercial Space

Versatile Commercial Space Off Highway

Versatile Office and Warehouse Space

Downtown Panama City Commercial Space

Panama City Flex Warehouse

Versatile Multi-Tenant Building For Lease

Remodeled Retail and Office Space

Office Space in Town Centre

Panama City Office Space

Customizable Office/Flex Space Available

Panama City Office Space

Flex Building with Office, Warehouse

Class A Office Space Available

Medical Office Space Available

Functional Office Building For Rent

Spacious Former Doctor's Office

Renovated Office Space For Rent

Downtown St Andrews Retail/Office Space

Commercial Flex Building For Lease

New Commercial Building on Navy

Class A Office Space Available

Spacious Medical Office Suite Available

Panama City, FL Office space Leasing Opportunities Market Analysis

Browse Office space for Lease Near Panama City, FL

Popular Searches in Panama City, FL

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Most Searched ZIP Codes in Panama City, FL

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