Office Building

Lexington, KY Office Buildings for Lease

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19 properties
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Renovated Historic Office Building
Updated: Jan 21
Renovated Historic Office Building

642 W Main Street, Lexington, KY 40508

$5,000/Mo
2,846 sqft 0.25 AC lot
2,846‑square‑foot office building constructed in 1855
Flexible layout for approximately 5 to 8 private offices
Full kitchen and dedicated break room
Covered front porch and two half bathrooms, one on each floor
B‑2 zoning on a 0.2468‑acre site
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18-Story Class-A Office Building
Updated: Jul 23, 2025
18-Story Class-A Office Building

333 W Vine Street, Lexington, KY 40507

$19 SF/Yr
3,770 sqft 0.40 AC lot
Approximately 45,000 contiguous SF available; suites are divisible and combinable
18‑story office building with concrete, steel, and glass construction
Signalized corners at Main/Mill and Vine/Mill
Connected parking garage plus additional Landlord‑owned parking nearby
24/7 tenant access, on‑site security, and electronic lobby directories
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Renovated Creative Office Space
Renovated Creative Office Space

146 E Third Street, Lexington, KY 40508

$18 SF/Yr
6,848 sqft 0.21 AC lot

Two-story office property with adaptable work areas, historic finishes, elevator access, and a private rooftop deck.

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Historic Office Building
Historic Office Building

117 W Second St, Lexington, KY 40507

$3,500/Mo
1,848 sqft

Two-level commercial building with office suites, meeting areas, kitchen, fireplaces, and B-2 zoning for office or retail use.

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Class-A Office Building
Class-A Office Building

333 W Vine Street, Lexington, KY 40507

$19 SF/Yr
14,826 sqft 0.40 AC lot

Multi-story office property with secure access, structured parking, and connections to nearby hospitality, entertainment, and convention amenities.

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Office Building Near Nicholasville Road
Office Building Near Nicholasville Road

2417 Regency Road, Lexington, KY 40503

$13.50 SF/Yr
9,880 sqft

Leasing opportunities in a +/-9,880 SF office building near Nicholasville Road and Regency Road.

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18-Story Class-A Office Building
18-Story Class-A Office Building

333 W Vine St Unit 500, Lexington, KY 40507

$18 SF/Yr
242,024 sqft 0.40 AC lot

Lexington office property with structured parking, loading access, and professionally managed building systems.

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Office Units with Connected Parking
Office Units with Connected Parking

333 W Vine St Unit 206, Lexington, KY 40507

$19 SF/Yr
242,024 sqft 0.40 AC lot

Multi-story office property offers contiguous space, controlled access, on-site security, and a connected parking garage.

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Renovated Two-Story Office Building
Renovated Two-Story Office Building

881 Corporate Drive, Lexington, KY 40503

$21.50 SF/Yr
27,247 sqft

Newly renovated two-story office building offers elevator, updated common areas, and available first-floor suites.

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Multi-Tenant Office Suite
Multi-Tenant Office Suite

2355 Huguenard Dr, Lexington, KY 40503

$16 SF/Yr
6,840 sqft 0.50 AC lot

First-floor office suite with dedicated exterior access, private rooms, meeting space, and kitchenette.

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Four-Story Office Building
Four-Story Office Building

151 N Eagle Creek Dr, Lexington, KY 40509

$18.95 SF/Yr
35,144 sqft

Multi-suite office space with full-height glass, scenic views, and access to three major Lexington roadways.

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Office Space with Strong Leestown Access
Office Space with Strong Leestown Access

1716-1720 Sharkey Way, Lexington, KY 40511

$18.50 SF/Yr

Office leasing in Townley Center with strong visibility and direct access to Leestown Road traffic.

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Renovated Multi-Tenant Office Suites
Renovated Multi-Tenant Office Suites

2387 Professional Heights Dr, Lexington, KY 40503

$18 SF/Yr

Flexible configurations, included utilities, and P-1 zoning support professional and service-oriented office uses.

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Single-Story Class A Office Building
Single-Story Class A Office Building

1745 Alysheba Way, Lexington, KY 40509

$17 SF/Yr
22,160 sqft

Professional, medical, and lab-oriented suites occupy a P-1-zoned office property with substantial specialized infrastructure.

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Class A Office Sublease Space
Class A Office Sublease Space

220 Lexington Green Circle, Lexington, KY 40503

Contact for pricing
1,505 sqft

Four-story office building with ample parking and natural light.

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Downtown Lexington Office/Retail Complex
Downtown Lexington Office/Retail Complex

401 W Main St, Lexington, KY 40507

$14.50 SF/Yr
207,801 sqft

140,000 SF office/retail complex in downtown Lexington.

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Lexington Office Building For Lease
Lexington Office Building For Lease

993 Mason Headley Rd, Lexington, KY 40504

$20.50 SF/Yr
13,594 sqft

Office building with high visibility and easy access.

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Class A Office Building
Class A Office Building

1792 Alysheba Way, Lexington, KY 40509

$24 SF/Yr
82,920 sqft

Premier Hamburg location with interstate access and ample parking.

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Lexington Office Building For Lease
Lexington Office Building For Lease

2401 Regency Rd, Lexington, KY 40503

$1,933/Mo
25,000 sqft

Office building near Nicholasville Road available for lease.

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Based on your search, we've compiled 57 Potential Opportunities for your consideration. Besides 19 Active listings in Lexington, KY, we suggest exploring alternatives. Similar 38 Properties for Sales.

Similar Spaces for Sale in Lexington, KY

Consider Similar Space for Sale. We found 38 Spaces matching your search parameters.

Brick Mixed-Use Office Property
Brick Mixed-Use Office Property

1618 Harrodsburg Road, Lexington, KY 40504

$500,000
2,240 sqft 0.28 AC lot

Main-level offices include reception, waiting, conference, and private work areas.

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Renovated Medical Office Building
Renovated Medical Office Building

160 Prosperous Place, Lexington, KY 40509

$1,650,000
6,840 sqft 0.57 AC lot

Two-story healthcare facility with exam rooms, procedure space, private offices, basement storage, and expansion area.

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Three-Story Office Building
Three-Story Office Building

997 Governors Lane, Lexington, KY 40513

$7,100,000
31,208 sqft 1.93 AC lot

Fully occupied professional offices with elevator service and a recently fitted second-floor suite.

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Renovated Multi-Tenant Office Building
Renovated Multi-Tenant Office Building

250 E Short Street, Lexington, KY 40507

$1,895,000
8,102 sqft 0.12 AC lot

Downtown office property with updated interiors, dedicated parking, and multiple existing occupants.

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Renovated Historic Office Building
Renovated Historic Office Building

146 E Third Street, Lexington, KY 40508

$1,750,000
6,848 sqft 0.21 AC lot

Two-story professional workspace with original architectural details, updated systems, elevator access, and flexible interior areas.

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Lexington, KY Office buildings Lease Rates & Market Statistics

Browse 19 Office buildings for lease in Lexington, KY on Realmo, a commercial real estate marketplace serving the Lexington area. The current inventory totals 946,277 square feet of properties — an average of ~49,800 SF per listing.

Asking lease rates for Office buildings in Lexington start at $13.50 SF/Yr, average $18.78 SF/Yr, and reach $24 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $18.78 SF/Yr is 6% below the Kentucky state average of $19.89 SF/Yr.

Lexington accounts for 100% of the 19 office buildings currently available across Fayette County. Office buildings make up 9% of the 220 Office Spaces currently for lease in Lexington, with asking rates averaging $18.78 SF/Yr — 21% below the citywide Office Spaces average of $23.78 SF/Yr. Also worth a look for tenants weighing alternatives: Office Units (192 listings) and Medical Office Space (24 listings) elsewhere in the Lexington market.

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