Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Des Peres, MO Commercial Real Estate for Lease

    13 results
    List
    Map
    Prime Land for Development
    Contact for pricing

    Prime Land for Development

    13205 Manchester Rd, Des Peres, MO 63131

    2 acres available in busy retail corridor near I-270.

    • High traffic location on Manchester Road (70,000+ vehicles per day).
    • Strong co‑tenants including Shake Shack, Panera, Chipotle, and Trader Joe’s.
    • Strong demographics with high average income ($174,273 within 3 miles).
    • Approximately 2 acres available for development.
    • Close proximity to Interstate 270 (1 mile) with high traffic (167,000+ vehicles per day).
    View details
    Des Peres Office Space Available
    Contact for pricing
    2,079 SF

    Des Peres Office Space Available

    13100 Manchester Rd, Des Peres, MO 63131

    Office space for rent in a convenient location.

    • Convenient Manchester/I‑270 Location
    • Abundant Parking
    • Common Corridors Recently Updated
    • Near Restaurants, West County Mall, Trader Joe’s & St. Louis Bread Company
    • Last Suite Available
    Updated: Dec 3, 2025
    View details
    Des Peres Office Space Available
    $32 SF/Yr
    5,630 SF

    Des Peres Office Space Available

    5,630 square feet of office space for lease.

    13075 Manchester Rd, Des Peres, MO 63131
    View details
    Des Peres Retail Space Available
    Contact for pricing
    5,335 SF

    Des Peres Retail Space Available

    Retail space in high-traffic Des Peres location for lease.

    12340-12360 Manchester Rd, Des Peres, MO 63131
    View details
    Retail Space Near West County
    Contact for pricing
    1,080 SF

    Retail Space Near West County

    Retail space with major renovations and high traffic location.

    1131-1193 Colonnade Ctr, Des Peres, MO
    View details
    Retail and Office Space Available
    Contact for pricing
    163 SF

    Retail and Office Space Available

    Mixed-use building with retail, office, and lower level space.

    12005-12085 Manchester Rd, Des Peres, MO 63131
    View details
    Des Peres Retail Space For Lease
    Contact for pricing
    2,186 SF

    Des Peres Retail Space For Lease

    Prime Des Peres location, 2186 sq ft retail space.

    12100 Manchester Rd, Des Peres, MO 63131
    View details
    Des Peres Medical Office Building
    $20 SF/Yr
    48,000 SF

    Des Peres Medical Office Building

    Class A, 1,989 SF Available

    2315 Dougherty Fry Rd, Des Peres, MO 63131
    View details
    Retail Space in Des Peres
    Contact for pricing
    1,396 SF

    Retail Space in Des Peres

    Retail space available in a shopping center in Des Peres.

    11925-11955 Manchester Rd, Des Peres, MO 63122
    View details
    Des Peres Corners Retail Space
    Contact for pricing
    120,673 SF

    Des Peres Corners Retail Space

    Prime St. Louis County retail, multiple spaces available.

    12332 Manchester Rd, Des Peres, MO 63131
    View details
    Retail Space in Des Peres
    Contact for pricing
    3,164 SF

    Retail Space in Des Peres

    Retail space available in Olympic Oaks Village, Des Peres, MO.

    12107-12129 Manchester Rd, Des Peres, MO 63122
    View details
    Retail Space in Des Peres
    Contact for pricing
    1,386 SF

    Retail Space in Des Peres

    Retail space available at a high-traffic intersection.

    1052-1090 N Ballas Rd, Des Peres, MO
    View details
    Medical Office Space Available
    Contact for pricing
    13,515 SF

    Medical Office Space Available

    Medical office space for lease in Des Peres, Missouri.

    1000 Des Peres Rd, Des Peres, MO
    View details
    Based on your search, we've compiled 22 Potential Opportunities for your consideration. Besides 13 Active listings in Des Peres, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office Space with Building Amenities
    $28 SF/Yr
    28,375 SF

    Office Space with Building Amenities

    Office space featuring 24/7 access and on-site management.

    1245 Jj Kelley Memorial Dr, Saint Louis, MO 63101
    View details
    Commercial Pad Site on Manchester
    Contact for pricing

    Commercial Pad Site on Manchester

    Pad site with great visibility and possible drive-thru.

    11768 Manchester Rd, Saint Louis, MO 63131
    View details
    Renovated Office Building Near I-270
    $21 SF/Yr

    Renovated Office Building Near I-270

    Recently renovated 30,000 SF office building with ample parking.

    1715 Deer Tracks Trl, Town and Country, MO 63131
    View details
    Office Space with Open Floorplan
    Contact for pricing
    8,121 SF

    Office Space with Open Floorplan

    First floor office suite with open layout and amenities.

    660-670 Mason Rdg Ctr Dr, Town and Country, MO
    View details

    Explore Similar Spaces for Sale in Des Peres, MO

    Consider Similar Space for Sale. We found 5 Spaces in Nearby Locations matching your search parameters.

    New Shake Shack with Drive-Thru
    Contact for pricing

    New Shake Shack with Drive-Thru

    2023 construction Shake Shack with drive-thru in St. Louis.

    13239 Manchester Rd, Des Peres, MO 63131
    View details
    Class A Office Building Package
    Contact for pricing

    Class A Office Building Package

    Three Class A office buildings totaling 289,380 SF for sale.

    1650 Des Peres Rd, Des Peres, MO 63131
    View details
    Des Peres Office Condo Suite
    Contact for pricing
    4,000 SF

    Des Peres Office Condo Suite

    Office condo with high-end finishes and easy highway access.

    13421 Manchester Rd, Des Peres, MO 63131
    View details
    Des Peres Commercial Building For Sale
    $1,250,000

    Des Peres Commercial Building For Sale

    8,310 SF building on 5 acres near Sam’s Club.

    2141-2153 Sams Dr, Des Peres, MO
    View details
    Leased Commercial Building with Homes
    Contact for pricing

    Leased Commercial Building with Homes

    Fully leased commercial building plus two residential homes for rent.

    1091 Kinstern Dr, Des Peres, MO
    View details

    Des Peres, MO Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Des Peres, MO with 18 listings featured on our commercial real estate exchange. The current inventory includes 2,336,122,800 square feet of properties with an estimated lease value of $52 SF/Yr.

    Estimated lease rates for Commercial real estate in Des Peres, MO begin at $20 SF/Yr, with an average of $26 SF/Yr and extend to $32 SF/Yr.
    List
    Map

    Browse Commercial real estate for Lease Near Des Peres, MO

    Popular Searches in Des Peres, MO

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!