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    Seneca, SC Commercial Real Estate for Sale

    105 results
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    Established Hibachi Restaurant for Sale
    $219,000

    Established Hibachi Restaurant for Sale

    1510 Blue Ridge Blvd, Seneca, SC 29672

    Turnkey Hibachi restaurant with existing lease and equipment included.

    • Established and successful Hibachi restaurant.
    • Includes all equipment and decorations.
    • Five‑year lease in place (two years remaining).
    • Ideal for investment or existing restaurant business expansion.
    • Avoid the challenges of starting a restaurant from scratch.
    Updated: Feb 20
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    Commercial Property on Radio Station Rd
    $250,000
    0.63 Acres

    Commercial Property on Radio Station Rd

    11081 N Radio Station Rd, Seneca, SC 29678

    Commercial property with road frontage, suitable for business location.

    • High‑traffic location on Radio Station Rd just outside Seneca city limits.
    • Great road frontage.
    • Suitable for remodeling or new construction.
    • Ideal for commercial property investors or business owners.
    • Existing building is block construction with concrete flooring.
    Updated: Dec 30, 2025
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    Turn-Key Restaurant Franchise Opportunity
    $1,900,000
    0.78 Acres

    Turn-Key Restaurant Franchise Opportunity

    Turn-key national franchise restaurant with real estate for sale.

    1053 By Pass 123 Byp, Seneca, SC 29678
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    Seneca Retail/Warehouse Opportunity
    $1,800,000
    1.01 Acres

    Seneca Retail/Warehouse Opportunity

    All brick/concrete building with existing tenants and expansion potential.

    518 N 1 St, Seneca, SC 29678
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    Commercial Land in Seneca, SC
    $275,000
    2.50 Acres

    Commercial Land in Seneca, SC

    2.5-acre commercial lot in Seneca, ready for development.

    13000 S Radio Station Rd, Seneca, SC 29678
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    Prime Downtown Seneca Land Parcel
    $65,000
    1.15 Acres

    Prime Downtown Seneca Land Parcel

    Private, wooded 1.15-acre lot near downtown Seneca, SC.

    Tbd - Lot B Grey Fox Ln, Seneca, SC 29678
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    Seneca Land for Sale
    $65,000
    1.03 Acres

    Seneca Land for Sale

    Over an acre of wooded land close to downtown Seneca.

    Tbd - Lot A Grey Fox Ln, Seneca, SC 29678
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    Commercial Land Near Highway 123
    $699,000
    1.80 Acres

    Commercial Land Near Highway 123

    Unrestricted 1.8-acre commercial land near major retailers and highways.

    1.8 Acres Rochester Hwy, Seneca, SC 29672
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    Prime Corner Parcel in Seneca
    $745,000
    5.10 Acres

    Prime Corner Parcel in Seneca

    5.1 acre commercial land with utilities and road frontage.

    Hwy 130 & Katelynn Ln, Seneca, SC 29672
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    Seneca Land Parcel For Sale
    $895,000
    6.90 Acres

    Seneca Land Parcel For Sale

    6.9 acre parcel approved for luxury garage condos.

    510-590 Brks Way, Seneca, SC 29672
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    Commercial Lot Near Wells Highway
    $395,000
    0.99 Acres

    Commercial Lot Near Wells Highway

    0.99-acre commercial lot with high visibility and easy access.

    Cor Of Wl Hwy. & Return Church Rd. Hwy, Seneca, SC 29678
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    Cleared Land Near Lake Keowee
    $125,000
    1.00 Acre

    Cleared Land Near Lake Keowee

    Cleared, level lot with lake views and road access.

    Maughan Trail/Mallard Bnd Rd, Seneca, SC 29672
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    Seneca Commercial Property with Expansion Potential
    $687,500
    3.95 Acres

    Seneca Commercial Property with Expansion Potential

    High-visibility commercial property ideal for storage, sales, or service center.

    298 Worth St, Seneca, SC 29678
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    Historical Brick Building in Seneca
    $999,949

    Historical Brick Building in Seneca

    Three-level, 15,600 SF building in Seneca's Opportunity Zone.

    235 Main St, Seneca, SC 29678
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    Commercial Land in Seneca, SC
    $325,000
    1.29 Acres

    Commercial Land in Seneca, SC

    Corner lot near downtown Seneca, suitable for various commercial uses.

    911 North 1St St, Seneca, SC 29678
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    Highway Frontage Commercial Land Opportunity
    $985,000
    1.45 Acres

    Highway Frontage Commercial Land Opportunity

    1.45 acres with highway frontage, ideal for development or lease.

    994 Lots, Seneca, SC 29678
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    Commercial Lot in Seneca, SC
    $590,000
    0.84 Acres

    Commercial Lot in Seneca, SC

    0.84 acre commercial lot in high-traffic Seneca location.

    994 By Pass 123 Hwy, Seneca, SC 29678
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    Prime Commercial Land in Seneca
    $3,500,000
    4.33 Acres

    Prime Commercial Land in Seneca

    4.3 acres with high visibility, ideal for retail development.

    1018 North 1St St, Seneca, SC 29678
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    Seneca Commercial Buildings For Sale
    $450,000
    1.02 Acres

    Seneca Commercial Buildings For Sale

    Two industrial buildings with flexible space and manufacturing potential.

    306 Byp Unit Building B And, Seneca, SC 29678
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    Prime Commercial Land Opportunity
    $545,000
    2.65 Acres

    Prime Commercial Land Opportunity

    2.65-acre commercial parcel in high-growth area, ideal for development.

    1800 Sandifer Blvd, Seneca, SC 29678
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    Seneca Commercial Land on Highway
    Pending
    $1,900,000
    102.70 Acres

    Seneca Commercial Land on Highway

    102.7 acres of commercial land with highway frontage.

    125 Armstrong Rd, Seneca, SC 29678
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    Seneca Commercial Land For Sale
    $3,833,000
    76.54 Acres

    Seneca Commercial Land For Sale

    76.66 acres of commercial land with utilities in Seneca, SC.

    unit Keowee Interior 76.66 Acres Frontage Rd And Knollwood Dr Rd, Seneca, SC 29678
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    Lake Keowee Interior Acreage
    $2,250,000
    45.00 Acres

    Lake Keowee Interior Acreage

    45+/- acres within Seneca city limits, utilities available.

    unit Keowee Interior 45+/- Acres Knollwood Dr, Seneca, SC 29678
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    Commercial Land in Seneca, SC
    $2,000,000
    3.94 Acres

    Commercial Land in Seneca, SC

    3.94 acres of commercial land with road frontage.

    10149 Clemson Blvd, Seneca, SC 29678
    View details

    Seneca, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 48 commercial real estate for sale in Seneca, SC, showcased through 105 active listings on our real estate platform. These investment opportunities span a total of 22,363,268 square feet of properties for sale, with an estimated market value of $46,196,944.

    Sale prices for business properties in Seneca, SC start at $65,000, averaging $1,215,709, and reaching up to $3,833,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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