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    Port St Lucie, FL Commercial Real Estate for Lease

    74 results
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    Freestanding Building on US Highway
    $26 SF/Yr
    46,609 SF

    Freestanding Building on US Highway

    10244 S Us Highway 1, Port St Lucie, FL 34952

    General Commercial zoning ideal for retail, medical, or restaurant.

    • High‑traffic location on US Hwy 1 with 35,500 AADT and 187' frontage.
    • General Commercial zoning suitable for retail, medical, restaurant, or professional use.
    • Ideal sub‑lease option with two separate entrances.
    • Existing electronic and media infrastructure wiring throughout.
    • Modular interior wall system allows for easy reconfiguration.
    Updated: Nov 16, 2025
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    Medical Office Space For Rent
    $24 SF/Yr
    998 SF

    Medical Office Space For Rent

    1801 SE Hillmoor Dr, Port St Lucie, FL 34952

    Updated medical office space available for rent in Port St. Lucie.

    • Updated with new vinyl plank flooring, paint, and cabinetry.
    • Features 3 exam rooms and 1 lab/kitchen.
    • Includes 2 bathrooms and 2 business offices.
    • Equipped with central heating and air conditioning.
    • Built in 1996 with block and concrete construction.
    Updated: Aug 31, 2025
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    Port St. Lucie Executive Office
    $1,527 / Mo
    998 SF

    Port St. Lucie Executive Office

    Executive office suite in Port St. Lucie medical corridor.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Professional Office Space Available
    $2,287 / Mo
    998 SF

    Professional Office Space Available

    Class A office suite with private offices and open space.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Executive Office Suites For Rent
    $500 / Mo
    231 SF

    Executive Office Suites For Rent

    Executive office suites available for lease in Port St. Lucie.

    951 SW Country Clb Dr, Port St Lucie, FL
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    Retail Space in Publix-Anchored Center
    $30 SF/Yr
    563 SF

    Retail Space in Publix-Anchored Center

    Retail space available in a busy, renovated shopping center.

    9020-9164 Us Highway 1, Port St Lucie, FL 34952
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    Visible Corner Office Space Available
    $24 SF/Yr
    3,900 SF

    Visible Corner Office Space Available

    Office space with high visibility and convenient access.

    481 Southwest Port St Lucie Blvd, Port St Lucie, FL 34953
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    Freestanding Office Space Available
    $25 SF/Yr

    Freestanding Office Space Available

    Office space for rent in high-visibility freestanding building.

    1399 SE Port St Lucie Blvd, Port St Lucie, FL 34952
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    Port St. Lucie Retail Center
    $23 SF/Yr

    Port St. Lucie Retail Center

    Retail strip center with high-traffic exposure on US-1 Highway.

    7630 S Us Highway 1, Port St Lucie, FL 34952
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    Commercial Plaza in Growing Tradition
    $40 SF/Yr
    2,122 SF

    Commercial Plaza in Growing Tradition

    Future commercial plaza in rapidly growing Tradition area.

    11650 SW Vlg Pkwy, Port St Lucie, FL
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    St. Lucie West Office Space
    $23 SF/Yr
    2,021 SF

    St. Lucie West Office Space

    Professional and medical office space in St. Lucie West.

    1660 SW St Lucie Blvd W, Port St Lucie, FL
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    Tradition Village Square Office Space
    $27 SF/Yr
    28,959 SF

    Tradition Village Square Office Space

    Office space for lease in vibrant Tradition community.

    10801 SW Tradition Sq, Port St Lucie, FL 34987
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    Anchored Retail Center For Lease
    $12 SF/Yr
    214,854 SF

    Anchored Retail Center For Lease

    Large retail center with national tenants on high-traffic intersection.

    10055 South Federal Hwy, Port St Lucie, FL 34952
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    Medical Office Space on US-1
    $18 SF/Yr
    5,473 SF

    Medical Office Space on US-1

    Newly renovated medical space with high visibility and convenient access.

    7664 South Hwy U.S, Port St Lucie, FL 34952
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    Office/Warehouse Space on Biltmore Street
    $1,600 / Mo

    Office/Warehouse Space on Biltmore Street

    Office and warehouse space available in a prime location.

    1720 SW Biltmore St, Port St Lucie, FL 34953
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    Retail/Office Space on US Highway
    $12 SF/Yr
    19,008 SF

    Retail/Office Space on US Highway

    Retail, office, or medical spaces with high visibility.

    10600-10642 South Federal Hwy, Port St Lucie, FL 34952
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    Retail Space For Lease
    $24 SF/Yr
    1,600 SF

    Retail Space For Lease

    Retail space available for lease in Port St. Lucie.

    10921-10941 Us 1, Port St Lucie, FL
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    Port St. Lucie Warehouse Space
    $1,331 / Mo

    Port St. Lucie Warehouse Space

    940 SF warehouse with office and loft for rent.

    1576 South Niemeyer Cir, Port St Lucie, FL 34952
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    Retail Space on Village Parkway
    Contact for pricing
    8,960 SF

    Retail Space on Village Parkway

    Versatile retail spaces in rapidly growing Port St. Lucie, Florida.

    10704 SW Vlg Pkwy, Port St Lucie, FL
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    Prime Retail Outparcel For Lease
    Contact for pricing
    10,000 SF

    Prime Retail Outparcel For Lease

    Retail outparcel for lease in high-traffic Port St. Lucie.

    10400 S Us Highway 1, Port St Lucie, FL 34952
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    St. Lucie West Office Building
    $35 SF/Yr
    18,000 SF

    St. Lucie West Office Building

    Office building in a fast-growing area with excellent visibility.

    9265 SW Commerce Ctr Dr, Port St Lucie, FL
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    St. Lucie West Office Building
    $35 SF/Yr
    18,000 SF

    St. Lucie West Office Building

    Office building in a high-growth area with excellent visibility.

    9265 Commerce Ctr Dr, Port St Lucie, FL 34986
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    Port St. Lucie Flex Warehouse
    $20 SF/Yr
    26,880 SF

    Port St. Lucie Flex Warehouse

    Flex warehouse buildings with office space and roll-up doors.

    532-534 Northwest Mercantile Pl, Port St Lucie, FL 34986
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    New Medical Building End Cap
    $32 SF/Yr
    12,784 SF

    New Medical Building End Cap

    End cap space in a newly constructed medical building.

    1070 Southwest Gatlin Blvd, Port St Lucie, FL 34953
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    Port St Lucie, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Port St Lucie, FL with 194 listings featured on our commercial real estate exchange. The current inventory includes 23,566,516,313 square feet of properties with an estimated lease value of $605 /Mo.

    Estimated lease rates for Commercial real estate in Port St Lucie, FL begin at $2 SF/Yr, with an average of $21 SF/Yr and extend to $40 SF/Yr.
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