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    Poplar Bluff, MO Commercial Real Estate for Sale

    105 results
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    Westwood Blvd Commercial Opportunity
    $599,500
    5,280 SF

    Westwood Blvd Commercial Opportunity

    2016 N Westwood Blvd, Poplar Bluff, MO 63901

    Prime commercial building on main thoroughfare with income potential.

    • Prime commercial location on Westwood Blvd with high visibility and traffic.
    • 5,280 sq ft +/- building with ample on‑site parking.
    • Existing lease with reputable medical tenant generating $3,322/month income.
    • Second unit (up to 2,640 sq ft +/-) available for lease or owner occupancy.
    • Attractive lease rate of $10/sq ft for the available unit.
    Updated: Dec 1, 2025
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    Commercial Building on 3.82 Acres
    $750,000
    4,560 SF

    Commercial Building on 3.82 Acres

    140 W Outer Rd, Poplar Bluff, MO 63901

    Multi-use building with expansion potential near future Interstate 57.

    • High‑visibility location near future Interstate 57 and M Hwy.
    • Multi‑use commercial building with 4560 sq ft under roof.
    • Includes existing spaces for both retail (salon) and office/sales.
    • Features a 1520 sq ft shop/garage area with 14 ft sidewalls.
    • Sits on 3.82 acres with room for expansion or additional buildings.
    Updated: Oct 27, 2025
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    Commercial Building with Rental Income
    $399,000
    3,600 SF

    Commercial Building with Rental Income

    3600 sq ft commercial building with three fully rented units.

    1600 W Maud St, Poplar Bluff, MO 63901
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    Turnkey Commercial Space with Warehouses
    $599,000
    4,337 SF

    Turnkey Commercial Space with Warehouses

    Two commercial buildings totaling 7437 SF on 3 acres.

    1401 Black Riv Industrial Park Rd, Poplar Bluff, MO 63901
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    Prime Commercial Building For Sale
    $1,500,000

    Prime Commercial Building For Sale

    Commercial building with four occupied units and highway visibility.

    2000 N Westwood Blvd, Poplar Bluff, MO 63901
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    Versatile Building in Poplar Bluff
    $325,000
    12,351 SF

    Versatile Building in Poplar Bluff

    12351 SF building suitable for various purposes in Poplar Bluff.

    338 Hazel St, Poplar Bluff, MO 63901
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    Versatile Commercial Space in Poplar Bluff
    $299,900
    3,475 SF

    Versatile Commercial Space in Poplar Bluff

    High-traffic location with remodeled space suitable for various business ventures.

    1025 S Westwood Blvd, Poplar Bluff, MO 63901
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    Versatile Commercial Property in Poplar Bluff
    $495,000

    Versatile Commercial Property in Poplar Bluff

    Two buildings with income potential in a high-traffic location.

    1029 S Westwood Rd, Poplar Bluff, MO 63901
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    Renovated Mixed-Use Commercial Space
    $79,900
    975 SF

    Renovated Mixed-Use Commercial Space

    Renovated commercial space with high visibility, suitable for various businesses.

    1614 S Broadway St, Poplar Bluff, MO 63901
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    Commercial Land in Poplar Bluff
    $399,000
    6.64 Acres

    Commercial Land in Poplar Bluff

    6.64 acres of commercial land ready for development.

    3387 Kanell Blvd, Poplar Bluff, MO 63901
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    Commercial Property in Poplar Bluff
    $1,495,000
    0.72 Acres

    Commercial Property in Poplar Bluff

    Commercial property with high traffic visibility and multiple business opportunities.

    3999 Highway Pp, Poplar Bluff, MO 63901
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    Mixed-Use Property in Rural Setting
    $220,000
    4,800 SF

    Mixed-Use Property in Rural Setting

    Live and work property bordering national forest near Poplar Bluff.

    5914 Highway W, Poplar Bluff, MO 63901
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    Poplar Bluff Commercial Building For Sale
    $950,000
    6,500 SF

    Poplar Bluff Commercial Building For Sale

    6,500 sq ft building on 1.74 acres in Poplar Bluff.

    1026 Us Highway 67 S, Poplar Bluff, MO 63901
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    Commercial Land in Poplar Bluff
    $950,000
    1.50 Acres

    Commercial Land in Poplar Bluff

    1.5 acre commercial land with two buildings in high-traffic area.

    1030 Us Highway 67 S, Poplar Bluff, MO 63901
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    Commercial Property in Poplar Bluff
    $48,000
    768 SF

    Commercial Property in Poplar Bluff

    Centrally-located commercial property suitable for investors or owner occupants.

    1517 Grove St, Poplar Bluff, MO 63901
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    Former Police Station For Sale
    $499,000
    8,000 SF

    Former Police Station For Sale

    8000 sq ft commercial property in Poplar Bluff, Missouri.

    1111 Poplar St, Poplar Bluff, MO 63901
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    Income-Producing Property in Poplar Bluff
    $300,000

    Income-Producing Property in Poplar Bluff

    Commercial property with storage units, office, and residential rental income.

    2710- Oakmoore Dr, Poplar Bluff, MO 63901
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    Commercial Lot in Poplar Bluff
    $89,500

    Commercial Lot in Poplar Bluff

    Level commercial lot with utilities in a retail center.

    Eugene Blvd, Poplar Bluff, MO 63901
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    Historic Mixed-Use Building
    $299,900
    0.29 Acres

    Historic Mixed-Use Building

    Charming downtown building with storefront and potential living quarters.

    400 Vine St, Poplar Bluff, MO 63901
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    Poplar Bluff Farmland Opportunity
    $60,000
    8.40 Acres

    Poplar Bluff Farmland Opportunity

    8 +/- acres of open farmland in a rural setting.

    693 County Road 605, Poplar Bluff, MO 63901
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    Commercial Lot on Highway 53
    $199,500

    Commercial Lot on Highway 53

    Commercial land with frontage on Highway 53 and city street.

    53 & Cross Highway, Poplar Bluff, MO 63901
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    Commercial Lot on Highway 53
    $249,500

    Commercial Lot on Highway 53

    One-acre commercial lot with highway frontage and utilities.

    800 Highway 53, Poplar Bluff, MO 63901
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    Poplar Bluff Land For Sale
    $399,000
    4.00 Acres

    Poplar Bluff Land For Sale

    4 acre commercial land tract with highway frontage and utilities.

    Hwy. 67 South, Poplar Bluff, MO 63901
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    Commercial Land in Poplar Bluff
    $65,000
    0.67 Acres

    Commercial Land in Poplar Bluff

    Commercial land available in Poplar Bluff, Missouri.

    2335 Cheshire Blvd, Poplar Bluff, MO 63901
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    Poplar Bluff, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 43 commercial real estate for sale in Poplar Bluff, MO, showcased through 105 active listings on our real estate platform. These investment opportunities span a total of 5,459,584 square feet of properties for sale, with an estimated market value of $8,112,000.

    Sale prices for business properties in Poplar Bluff, MO start at $48,000, averaging $386,285, and reaching up to $1,495,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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