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    Anderson, SC Commercial Real Estate for Lease

    42 results
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    Downtown Anderson Commercial Space For Rent
    $1,150 / Mo
    2,614 SF

    Downtown Anderson Commercial Space For Rent

    122 W Whitner St, Anderson, SC 29624

    Versatile 1,300 SF space in historic downtown Anderson.

    • Prime location in historic downtown Anderson, across from the Anderson County Courthouse.
    • Versatile 1,300 square‑foot upper‑level space suitable for office, retail, or studio.
    • Adjacent to the City Parking Garage with ample street parking available.
    • Wood flooring throughout.
    • Adaptable floor plan.
    Updated: Feb 25
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    Class A Office Space
    $3,400 / Mo

    Class A Office Space

    2315 N Main St, Anderson, SC 29621

    Professional office suite for rent in Anderson, SC.

    • Prime Main Street location ideal for high‑visibility professional business.
    • Class A office building with included maintenance, electric, and water.
    • Versatile 2,800 sq ft suite suitable for medical or professional use.
    • Functional layout with five private offices, open floor plan, two restrooms, and a kitchen area.
    • Includes a welcoming reception area and large parking space.
    Updated: Dec 9, 2025
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    Industrial Building in Anderson, SC
    $5,500 / Mo

    Industrial Building in Anderson, SC

    Industrial building suitable for wholesale distribution in Anderson, SC.

    1821 S Mcduffie St, Anderson, SC 29624
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    Retail Space Near Major Anchors
    Contact for pricing

    Retail Space Near Major Anchors

    Retail space for lease near Publix, Burlington, Walmart, Best Buy.

    3801 Clemson Blvd, Anderson, SC 29621
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    Office Space on Hwy 81
    $15 SF/Yr
    2,683 SF

    Office Space on Hwy 81

    Office space for lease near downtown Anderson and Anderson University.

    1704 E Greenville St, Anderson, SC 29621
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    Retail Space in Publix Anchored Center
    Contact for pricing
    2,800 SF

    Retail Space in Publix Anchored Center

    2,800 SF retail space available in Anderson, SC.

    3801 Clemson Blvd, Anderson, SC 29621
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    Heated Warehouse Near Clemson Boulevard
    $7 SF/Yr
    7,500 SF

    Heated Warehouse Near Clemson Boulevard

    5,000 sqft heated warehouse with office space for lease.

    107 Control Dr, Anderson, SC 29625
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    New Flex Space Available
    $15 SF/Yr
    6,721 SF

    New Flex Space Available

    New construction flex buildings with I-85 frontage for lease.

    2036 Frontage Rd, Anderson, SC 29621
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    Professional Office Space Available
    Contact for pricing
    3,000 SF

    Professional Office Space Available

    Well-maintained office park near US 178/N. Main St.

    341 E Beltline Blvd, Anderson, SC 29621
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    Publix Anchored Retail Space
    Contact for pricing

    Publix Anchored Retail Space

    Retail space available in a Publix-anchored shopping center.

    Anderson, SC 29621
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    121,000 SF Industrial Space Available
    Contact for pricing
    121,000 SF

    121,000 SF Industrial Space Available

    Industrial space with interstate access and laydown yard.

    2 Green Tree Rd, Anderson, SC 29625
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    Retail Space on Clemson Boulevard
    $14 SF/Yr
    8 SF

    Retail Space on Clemson Boulevard

    Retail space available for lease in Anderson, South Carolina.

    4132 Clemson Blvd, Anderson, SC 29621
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    Anderson SC Flex Building For Rent
    Contact for pricing
    12,380 SF

    Anderson SC Flex Building For Rent

    12,380 SF flex building with exceptional access and visibility.

    4106 Liberty Hwy, Anderson, SC 29621
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    Industrial Space for Lease
    $9 SF/Yr
    26 SF

    Industrial Space for Lease

    26,400 SF industrial space available for lease.

    111 Preamble Ct, Anderson, SC 29621
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    Retail Space Available For Rent
    Contact for pricing
    1,200 SF

    Retail Space Available For Rent

    Retail space available for lease, approximately 1,200 square feet.

    3003 S Main Street Ext, Anderson, SC 29624
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    Regional Mall Retail Space
    Contact for pricing
    90,750 SF

    Regional Mall Retail Space

    90,750 SF retail space in Anderson's main corridor.

    3101-3187 N Main St, Anderson, SC 29621
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    Retail Space in Power Center
    Contact for pricing
    1,200 SF

    Retail Space in Power Center

    Retail space available in a busy power center.

    172 Station Dr, Anderson, SC 29621
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    Retail Space in Anderson, SC
    Contact for pricing
    23,500 SF

    Retail Space in Anderson, SC

    Community shopping center with national and local tenants for rent.

    3104-3140 N Main St, Anderson, SC 29621
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    Retail Space in Anderson, SC
    Contact for pricing
    400 SF

    Retail Space in Anderson, SC

    Retail space available with recent renovations and strong anchor tenants.

    2905 N Main St, Anderson, SC 29624
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    Retail Space Near Downtown Anderson
    Contact for pricing
    2,696 SF

    Retail Space Near Downtown Anderson

    Retail space with high visibility near downtown Anderson, South Carolina.

    1626 N Main St, Anderson, SC 29621
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    Office Space with Recent Upgrades
    Contact for pricing
    4,200 SF

    Office Space with Recent Upgrades

    Office space featuring new exterior paint and resurfaced parking lot.

    120 E West Pkwy, Anderson, SC 29621
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    Industrial Space in Anderson, SC
    Contact for pricing
    125,000 SF

    Industrial Space in Anderson, SC

    125,000 SF industrial space for lease in Anderson, SC.

    230 Masters Blvd, Anderson, SC 29626
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    Retail Shop for Lease
    $5,000 / Mo

    Retail Shop for Lease

    Retail space available for lease.

    00 Burts Garage Rd, Anderson, SC 29626
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    Prime Highway Frontage Land Available
    Contact for pricing

    Prime Highway Frontage Land Available

    15 acres with 1,200+ feet of highway frontage.

    Hwy 81 & Cornelia Rd, Anderson, SC
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    Anderson, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Anderson, SC with 177 listings featured on our commercial real estate exchange. The current inventory includes 20,262,613,540 square feet of properties with an estimated lease value of $174 SF/Yr.

    Estimated lease rates for Commercial real estate in Anderson, SC begin at $1.00 SF/Yr, with an average of $11 SF/Yr and extend to $25 SF/Yr.
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