5221-5335 McCullough Avenue, San Antonio, TX 78212

Spaces For Lease

at 5221-5335 McCullough Avenue Contact us

Listing agent Vicki Adelstein License #TX540915

Listing office Partners Real Estate

Listing date Jun 13, 2026

Source Crexi

Displayed information is deemed reliable but is not guaranteed and should be independently verified.

All listing content including descriptions, pricing, images are the copyrighted material of Partners Real Estate

Report an issue

---

Overview

This offering provides multi-tenant retail space with seven available suites for lease. Available space ranges from smaller footprints to larger configurations within the same property, giving tenants room to right-size their retail concept.

The property is located at 5221-5335 McCullough Avenue in San Antonio, Texas 78212. It’s a straightforward retail setup intended for businesses seeking dedicated storefront-style space within a shared commercial environment.

Suites of varying sizes can accommodate a range of retail operators, including service-focused and product-based businesses that need a dedicated space rather than a shared desk or kiosk arrangement. If you are evaluating locations for a retail rollout, pop-up, or established storefront, the availability of multiple suites in one property may simplify planning and leasing compared with searching across separate buildings.

For more leasing details on current availability and specific suite dimensions, contact the listing team.

Suggested Use

Real Estate Agency Law Firm Restaurant Spa & Massage Center Dental Office Hair Salon Nail Salon Building Supply Gym & Fitness Center Daycare Center

Zoning and permitted uses should be independently verified with local authorities.

Location Insight

• Map
• Local Demand

City

San Antonio

County

Comal

State

Texas

Longitude

-98.4917294

Latitude

29.4792575

Nearby Similar for Lease

• Sponsored

  

  $129-$10,768/Mo

  11-1,830 SF

  TX, San Antonio - Broadway Street

  4040 2Nd St, Unit 78209, San Antonio, TX 78209

  View Details
• 

  $3,000/Mo

  1,351 SF

  Live-Work or Office Property

  Flexible 2-bedroom, 2-bath layout with a fenced yard and fireplace, with a foundation replacement completed in 2014.

  821 E Quincy St, San Antonio, TX 78215

  View Details
• 

  $50 SF/Yr

  5,821 SF

  Turnkey Restaurant with Patio

  Turnkey 6,000+ sf restaurant with ADA features, a full FFE package, and patio seating for immediate operations.

  604 S ALAMO ST, San Antonio, TX 78205

  View Details
• 

  $11 SF/Yr

  3,200 SF

  Flex Industrial Warehouse with Office

  Move-in ready flex space with built-out office, fenced yard, and on-site property management.

  1890 South Brazos Street, San Antonio, TX 78207

  View Details
• 

  $129-$29,607/Mo

  11-2,137 SF

  TX, San Antonio - San Pedro Ave

  13750 San Pedro Ave, Unit 730, San Antonio, TX 78232

  View Details
• 

  $129-$16,480/Mo

  11-2,141 SF

  TX, San Antonio - NE Loop 410

  40 Loop 410, Unit 100, San Antonio, TX 78216

  View Details
• 

  $129-$28,355/Mo

  11-2,016 SF

  North Stone Oak

  18756 Stone Oak Pkwy, Unit 200, San Antonio, TX 78258

  View Details
• 

  $129-$17,650/Mo

  11-2,058 SF

  TX, San Antonio - Soledad St

  454 Soledad St, Unit 3RD, San Antonio, TX 78203

  View Details
• 

  $129-$28,261/Mo

  11-2,194 SF

  Two Twin Oaks

  227 Loop 1604, Unit 150, San Antonio, TX 78232

  View Details
• 

  $129-$19,720/Mo

  11-2,107 SF

  Sonterra

  401 Sonterra Blvd, Unit 375, San Antonio, TX 78258

  View Details
• 

  $129-$14,696/Mo

  11-2,004 SF

  San Antonio Airport

  1777 Loop 410, Unit 600, San Antonio, TX 78217

  View Details
• 

  $129-$26,283/Mo

  11-2,124 SF

  Eilan

  17806 Ih 10, Unit 300, San Antonio, TX 78257

  View Details

FAQs

What type of property is this?

Retail space - Seven retail suites are available for lease, offering flexible options for neighborhood-oriented users.

Where is this retail space located?

The property is located at 5221-5335 McCullough Avenue San Antonio, TX.

What are key features of this property?

This property features: Retail space for lease with 7 available suites; Suite sizes range from 495 SF to 1,760 SF