4220 Duncan Ave St Saint Louis, MO

Spaces For Lease

at 4220 Duncan Ave St Contact us

Listing Agency: Colliers Show Phone

Listed By: Tony Kennedy, CCIM · License #MO 1999080493 Show Phone

Source: Moodyscre

Added: Nov 23, 2025 Changed: Jul 6 Last Checked: Jul 21 at 4:17AM

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Investment Insights

Based on property information with market context.

A 5,263 square-foot restaurant space is available for lease. The property is located in the heart of the Cortex Innovation District and is ready for immediate occupancy. The fully built-out restaurant includes two expansive outdoor patios totaling 2,126 square feet. The patios are suitable for high-volume dining, events, and seasonal activation. The property is suitable for restaurants, retail properties, and turnkey restaurants.

Key Highlights

• Turnkey 5,263 SF restaurant space ready for immediate occupancy.
• Located in the heart of the Cortex Innovation District.
• Includes two expansive outdoor patios totaling 2,126 square feet.

Property Analytics

Location Intelligence

Current Use

Isalis (Bike/Boat/Book/etc) Store Party City Party Supply Store Skunk Funk Big Box & Wholesale Store Carl's Trading Co Hat Shop Bushka's Kitchen LLC (Bike/Boat/Book/etc) Store

Suggested Use

Top Pick Auto Parts Store Grocery & Convenience Store HVAC Service (Bike/Boat/Book/etc) Store Barber Shop Veterinary Clinic

Zoning and permitted uses should be independently verified with authorities.

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Frequently Asked Questions

What type of property is this?

Restaurant - Ready-to-operate restaurant with patios in the Cortex Innovation District.

Where is this restaurant located?

The property is located at 4220 Duncan Ave St Saint Louis, MO.

What are key features of this property?

This property features: Turnkey 5,263 SF restaurant space ready for immediate occupancy.; Located in the heart of the Cortex Innovation District.; Includes two expansive outdoor patios totaling 2,126 square feet.