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Turnkey Restaurant Space in Cortex
For Lease
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4220 Duncan Ave, Saint Louis, MO 63110

Ready-to-operate restaurant with patios in the Cortex Innovation District.

Space Size5,263 SF - 11,391 SF
Lot Size1.76 Acres
Days on Market315

Property Features for 4220 Duncan Ave

General Information

Standard status Active
Size 5,263 SF - 11,391 SF
Lot size 1.76 Acres
Property subtype RETAIL

Spaces For Lease

at 4220 Duncan Ave Contact us

Suite 303 AVAILABLE, Now

Floor 3
Size 7,707 SF
Type OFFICE
Rate Contact for pricing
Sublease No
4220 Duncan is an expanded venue for innovation and entrepreneurism for small and large companies seeking to locate in the hub of the St. Louis life science and technology marketplace. Suite 303 - 7,707 SF Office Space Available - Plug and Play Condition - Move-in Ready - Large Training Room
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Suite 403 AVAILABLE, Now

Floor 4
Size 11,391 SF
Type OFFICE
Rate Contact for pricing
Sublease No
4220 Duncan is an expanded venue for innovation and entrepreneurism for small and large companies seeking to locate in the hub of the St. Louis life science and technology marketplace. Suite 403 - 11,391 SF Office Space Available - Plug and Play Condition - Move-in Ready - New Furniture Included - Prime Elevator Lobby Entrance
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Turnkey Restaurant Space Available for Lease AVAILABLE, Now

Size 5,263 SF
Type RETAIL
Rate Contact for pricing
Lease Type GROSS
Turnkey Restaurant Space Available for Lease in the Heart of the Cortex Innovation District. Ready for Immediate Occupancy. This fully built-out 5,263 SF restaurant space is available immediately and includes two expansive outdoor patios totaling 2,126 square feet—ideal for high-volume dining, events, and seasonal activation.
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Listing Agency: SmartEquity
Listed By: Brandon Smart · License #2016006331
Source: Moodyscre
Added: Nov 23, 2025 Changed: Oct 3 Last Checked: Oct 4 at 6:10AM

Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of SmartEquity

Investment Insights

Based on property information with market context.

A 5,263 square-foot restaurant space is available for lease. The property is located in the heart of the Cortex Innovation District and is ready for immediate occupancy. The fully built-out restaurant includes two expansive outdoor patios totaling 2,126 square feet. The patios are suitable for high-volume dining, events, and seasonal activation. The property is suitable for restaurants, retail properties, and turnkey restaurants.

Key Highlights

  • Turnkey 5,263 SF restaurant space ready for immediate occupancy.
  • Located in the heart of the Cortex Innovation District.
  • Includes two expansive outdoor patios totaling 2,126 square feet.

Property Analytics

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Current Use

Turn key restaurants

Suggested Use

Top Pick Auto Parts Store Grocery & Convenience Store HVAC Service (Bike/Boat/Book/etc) Store Barber Shop Veterinary Clinic

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Lease Details

NNN (Triple Net)
Lease Type

Location Intelligence

Trade Area within ½ mile

5,302
Businesses Nearby
78k
Monthly Visits Nearby
Well-served
Demand for This Use

Foot Traffic Nearby

Hotels & Casinos 38% Dining 32% Groceries 16% Shops & Services 13%
McDonald's Dining
22,069 visits/mo 0.5 miles
Marriott St. Louis Grand Hotels & Casinos
13,023 visits/mo 0.1 miles
Schnucks Groceries
12,829 visits/mo 0.0 miles
Holiday Inn St. Louis - Downtown Conv Ctr Hotels & Casinos
7,878 visits/mo 0.2 miles
Hampton Inn St. Louis-Downtown at the Gateway Arch Hotels & Casinos
6,458 visits/mo 0.4 miles

Demographics for 63110, MO

18,199
Population
10,260
Households
1.8
Avg Household Size
33
Median Age
64%
College-Educated
97%
High-School Grad
6.6 sq mi
ZIP Area
2,757
Density / Sq Mi
$73,809
Median Household Income
$55,340
Median Earnings
$1,183
Median Rent
$314,600
Median Home Value
Check the figures for this property Cap Rate, Value Estimation, Potential NOI and more
View Realmo Analytics

Market

Vacancy Rate% for Retail in Midwest region

8% 2020
7.3% 2021
6.5% 2022
6% 2023
5.7% 2024
6.3% 2025
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Similar Off Market Nearby

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  • Red Zucchini PCS & Catering — 1610 Olive St, St. Louis, MO 63103
  • Nirvana Catering — 1610 Olive St, St. Louis, MO 63103
  • Centenary Commissary Kitchen — 1610 Olive St, St. Louis, MO 63103
  • The Croquetterie — 1610 Olive St, St. Louis, MO 63108

Frequently Asked Questions

What type of property is this?
Restaurant - Ready-to-operate restaurant with patios in the Cortex Innovation District.
Where is this restaurant located?
The property is located at 4220 Duncan Ave Saint Louis, MO.
What are key features of this property?
This property features: Turnkey 5,263 SF restaurant space ready for immediate occupancy.; Located in the heart of the Cortex Innovation District.; Includes two expansive outdoor patios totaling 2,126 square feet.
(314) 345-0533 Call to check price and availability
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