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Two-Story Mixed-Use Building
For Sale
$475,000

421 W Twohig Avenue, San Angelo, TX 76903

Commercial Sale, San Angelo, TX

Property Size4,366 SF
Lot Size0.36 Acres
Price / SF$108.80
Days on Market48

Property Features for 421 W Twohig Avenue

General Information

Property type Commercial Sale
Property subtype Office
Zoning description General Commercial
Parking features Carport, On Street, Driveway
Subdivision San Angelo
Standard status Active
APN R000005756
Size 4,366 SF
Lot size 0.36 Acres

Taxes and HOA fees

Tax Description Acres: 0.364 Lot: 15 & E33.5 Of 14 Blk: 30 Subd: San Angelo Addition
Legal Description Acres: 0.364 Lot: 15 & E33.5 Of 14 Blk: 30 Subd: San Angelo Addition

Utilities

Sewer type Public Sewer
Heating system Forced Air, Central, Electric (Heating)
Cooling system Central Air, Electric
Water source Public

Building Details

Year built 1962
Floors in Building 2
Flooring type Tile, Carpet, Wood
Building materials Brick
Roof type Metal, Composition
Listing Agency: Keller Williams Synergy · Keller Williams Realty
Listed By: Danielle Ellise Group
Added: Jul 24 Changed: Aug 26 Last Checked: Sep 9 at 1:06PM
MLS# 201758

Copyright © 2026 San Angelo Association of Realtors. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified.

Investment Insights

Based on property information with market context.

Built in 1962, this two-story mixed-use property contains 4,366 square feet on a 0.36-acre lot. The building combines commercial space on the first floor with an upstairs apartment, creating a live-work configuration within a brick structure. Interior finishes include tile, carpet, and wood flooring, while central air, forced-air heating, public water, and public sewer serve the property.

Outdoor features include a wraparound porch, patio areas on both levels, and rear parking with a carport, driveway, and on-street options. Separate rear storage adds functional support space. The property is located at 421 W Twohig Avenue in San Angelo, within the 76903 postal area. Potential TIRZ funding for qualifying exterior improvements and possible eligibility for a Texas state historic tax credit are identified as additional considerations.

Key Highlights

  • 4,366‑square‑foot mixed‑use building on a 0.36‑acre lot
  • Two‑story layout with commercial space below and an upstairs apartment
  • Brick construction with tile, carpet, and wood flooring

Property Analytics

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Current Use

Anderson Thomas F ... Dental Office

Suggested Use

Top Pick Parking Lot & Garage Dental Office (Bike/Boat/Book/etc) Store Veterinary Clinic Catering Service Daycare Center

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Location Intelligence

Trade Area within ½ mile

1,872
Businesses Nearby

Demographics for 76903, TX

32,215
Population
14,169
Households
2.3
Avg Household Size
37
Median Age
16%
College-Educated
78%
High-School Grad
25.0 sq mi
ZIP Area
1,289
Density / Sq Mi
$49,045
Median Household Income
$33,077
Median Earnings
$1,051
Median Rent
$115,900
Median Home Value
Check the figures for this property Cap Rate, Value Estimation, Potential NOI and more
View Realmo Analytics

Market

Vacancy Rate% for Office in South region

14.4% 2019
16.4% 2020
17.3% 2021
18% 2022
18.6% 2023
20.3% 2024
20.2% 2025
Rey
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Frequently Asked Questions

What type of property is this?
Mixed-use property - Main-level commercial space pairs with an upstairs apartment and outdoor areas.
Where is this mixed-use property located?
The property is located at 421 W Twohig Avenue San Angelo, TX.
What is the asking price?
The asking price for this property is $475,000.
What are key features of this property?
This property features: 4,366‑square‑foot mixed‑use building on a 0.36‑acre lot; Two‑story layout with commercial space below and an upstairs apartment; Brick construction with tile, carpet, and wood flooring
More about this property
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