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421 W Twohig Avenue, San Angelo, TX, 76903
Two-Story Live-Work Building with Apartment

421 W Twohig Avenue San Angelo, TX 76903

New
For Sale
$475,000

COMMERCIAL - San Angelo, TX

Property Size4,366 SF
Lot Size0.36 Acres
Price / SF$108.80
Days on Market3

Property Features for 421 W Twohig Avenue

General Information

Property type
Commercial Sale
Property subtype
Office
Parking features
Driveway, Carport, On Street
Standard status
Active
APN
23-41700-0300-013-00
Size
4,366 SF
Lot size
0.36 Acres

Taxes and HOA fees

Tax Description
Acres: 0.364 Lot: 15 & E33.5 Of 14 Blk: 30 Subd: San Angelo Addition

Utilities

Sewer type
Public Sewer
Heating system
Electric (Heating), Forced Air, Central
Cooling system
Electric, Central Air
Water source
Public

Building Details

Year built
1962
Floors in Building
2
Flooring type
Tile, Carpet, Wood
Building materials
Brick
Roof type
Composition, Metal
Listing Agency: Keller Williams Synergy
Listed By: Danielle Ellise Group
Added: Jul 24 Last Checked: Jul 26 at 8:06AM
MLS# 201758

Copyright © 2026 San Angelo Association of Realtors. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified.


Investment Insights

Based on property information with market context.

Located at 421 W Twohig Avenue in San Angelo, this two-story live-work building combines commercial and residential use in a single structure. The property includes an apartment upstairs, while the main level offers space for a variety of business ventures. Interior details include soaring ceilings, exquisite millwork, and a prominent staircase, supporting the building’s distinct historic character.

Exterior features include a wraparound porch and patio areas upstairs and downstairs, along with a rear carport that provides convenient parking plus separate storage. The lot size is approximately 0.36 acres, with a total building size of 4,366 square feet.

For buyers considering renovations or exterior improvements, the remarks note potential TIRZ funding through the City of San Angelo for qualifying exterior work and possible qualification for Texas state historic tax credits. This combination of flexible layout and period character can fit a range of owner-user and investor strategies.

Key Highlights

  • Two‑story brick building built in 1962 with historic architectural details including soaring ceilings and a staircase
  • Mixed‑use design with an apartment upstairs and flexible main‑level space for commercial or residential use
  • Wraparound porch plus patio areas upstairs and downstairs

Property Analytics

Property Profile Location Intelligence

Current Use by Public Records

Anderson Thomas F ... Dental Office

Suggested Use

Parking Lot & Garage Dental Office (Bike/Boat/Book/etc) Store (Bike/Boat/Book/etc) Store Veterinary Clinic Catering Service (Bike/Boat/Book/etc) Store Daycare Center Locksmith Computer & Electronic Repair

Zoning and permitted uses should be independently verified with local authorities.

FAQs

What type of property is this?
Live-work space - Two-story building with a commercial main level and an apartment upstairs, plus a wraparound porch and rear carport parking.
Where is this live-work space located?
The property is located at 421 W Twohig Avenue San Angelo, TX.
What is the asking price?
The asking price for this property is $475,000.
What are key features of this property?
This property features: Two‑story brick building built in 1962 with historic architectural details including soaring ceilings and a staircase; Mixed‑use design with an apartment upstairs and flexible main‑level space for commercial or residential use; Wraparound porch plus patio areas upstairs and downstairs
More about this property
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