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    Transit-Oriented Life Science/Tech Space Title is generated by Realmo AI

    20 Southline Avenue- Bldg. 1- Phase 1, South San Francisco, CA 94080

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    Class A life science and tech campus near BART and Caltrain.

    Type:Industrial
    Property size:
    55,000 SF
    Lot size:
    7.00 Acres
    Added:
    Jan 27, 2026
    Days on Market:
    125
    Last Refresh:
    Apr 5 at 11:37 pm

    Property Features for 20 Southline Avenue- Bldg. 1- Phase 1

    General Information

    Standard status
    Active
    Size
    55,000 SF
    Lot size
    7.00 Acres
    Property subtype
    Industrial

    Spaces For Lease

    at 20 Southline Avenue- Bldg. 1- Phase 1 Contact us

    We can help!

    Listing Contact
    Dan Matteucci
    Dan Matteucci

    Listing agent Dan Matteucci License #CalDRE #01848064

    Listing office Newmark | San Mateo

    Listing date Jan 27, 2026

    Source Nmrk

    Displayed information is deemed reliable but is not guaranteed and should be independently verified.

    All listing content including descriptions, pricing, images are the copyrighted material of Newmark | San Mateo

    HighLights

    • Unparalleled Transit Access: Immediate access to 101/380/280, Caltrain, BART, and SFO.
    • Ideal Location: Situated directly between Downtown South San Francisco and Downtown San Bruno.
    • New Class A campus specifically designed for life science and technology companies.
    • Substantial Amenities: Includes an 80,000 SF amenities building with a restaurant and gym, plus a bar with an outdoor terrace.
    • Large Floorplates: Features 55,000 SF floorplates suitable for various layouts.
    • Extensive Outdoor Space: Offers 7 acres of outdoor space, including a beer garden.

    Overview

    This industrial space is available for lease in a new Class A life science and tech campus. The property is located directly at a BART station and 0.5 miles from Caltrain, offering immediate access to highways 101, 380, and 280, as well as SFO. Situated between Downtown South San Francisco and Downtown San Bruno, this transit site features 55,000 square foot floorplates and potential for spec suites. Phase 1 encompasses 720,000 square feet. An 80,000 square foot amenities building includes a restaurant and gym, along with a bar featuring an outdoor terrace. The site also offers 7 acres of outdoor space, including a beer garden. This location is suitable for life science and technology companies.
    Location Intelligence

    Current Use by Public Records

    Specialty properties

    Map

    City
    South San Francisco
    County
    San Mateo
    State
    California
    Longitude
    -122.426
    Latitude
    37.6562

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    FAQs

    What type of property is this?
    Specialty property - Class A life science and tech campus near BART and Caltrain.
    Where is this specialty property located?
    The property is located at 20 Southline Avenue- Bldg. 1- Phase 1 South San Francisco, CA.
    What are key features of this property?
    This property features: Unparalleled Transit Access: Immediate access to 101/380/280, Caltrain, BART, and SFO.; Ideal Location: Situated directly between Downtown South San Francisco and Downtown San Bruno.; New Class A campus specifically designed for life science and technology companies.
    (650) 358-5276
    We can help!
    Listing Contact
    Dan Matteucci
    Dan Matteucci
    Real Estate License ID: CalDRE #01848064
    Learn More
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    Realmo Value Estimations

    Realmo estimates a property’s market value using a proprietary methodology that incorporates public data and user-submitted information. This cumulative value is generated by integrating a variety of conventional and innovative methods. 

    Disclaimer

    These figures are not official appraisals and should not be used as a substitute for a valuation performed by a licensed appraiser.
    Actual market value may differ due to factors not captured in the data. Estimates are offered for informational purposes only, and users should conduct independent research before making financial or investment decisions.
    By using this feature, you acknowledge that Realmo is not responsible for actions taken based on these estimates.

    AI approach

    Realmo AI Method estimates property value using machine learning models trained on millions of comparable listings, transactions, and market signals. It analyzes property features, location intelligence data, and current market dynamics to predict the most probable market value in real time.

    Realmo CapRate Calculation

    Realmo calculates the Capitalization Rate (Cap Rate) to help estimate a property's potential return on investment. The Cap Rate is a fundamental metric in commercial real estate that measures the relationship between a property's net operating income and its market value.

    How We Calculate Cap Rate

    Cap Rate Formula:
    Cap Rate (%) = (Net Operating Income / Property Value) × 100

    Net Operating Income (NOI) Formula:
    NOI = Area × Lease Rate × (1 - Vacancy Rate) × (1 - Operating Expense Ratio)

    Components

    Net Operating Income (NOI) represents the annual income a property generates after operating expenses:

    • Area: Building square footage from property records
    • Lease Rate: Annual $/sqft based on market data for the property type and geographic location
    • Vacancy Rate: Percentage of unoccupied space based on market data for the property type and location
    • Operating Expense Ratio: Operating costs as a percentage of income, varies by property type

    Property Value is derived from:

    • Recent sale price (if available)
    • Statistical models using comparable sales
    • AI-powered valuation estimates

    Example Calculation

    For a 100,000 sqft Office Building:

    • Lease Rate: $25.00/sqft/year (market data for Office in this area)
    • Vacancy Rate: 8% (market data for Office in this area)
    • Operating Expense Ratio: 35% (typical for Office properties)
    • Property Value: $15,000,000

    Step 1: Calculate NOI

    NOI = 100,000 × $25.00 × (1 - 0.08) × (1 - 0.35)
    NOI = 100,000 × $25.00 × 0.92 × 0.65
    NOI = $1,495,000/year

    Step 2: Calculate Cap Rate

    Cap Rate = ($1,495,000 / $15,000,000) × 100
    Cap Rate = 9.97%

    Property Type Considerations

    Net Operating Income calculations vary by property type due to different operating expense ratios:

    • Office: Higher expenses (30-40%) for HVAC, utilities, maintenance
    • Retail: Moderate expenses (25-35%) for common area maintenance
    • Industrial/Warehouse: Lower expenses (15-25%) for minimal tenant services
    • Multifamily: Moderate expenses (35-45%) including property management
    • Self-Storage: Lower expenses (25-35%) due to minimal maintenance

    Market lease rates and vacancy rates are specific to each property type and geographic location, reflecting local market conditions.

    Disclaimer

    These calculations are estimates for informational purposes only and should not be used as a substitute for professional financial analysis or appraisal.

    • Cap Rate calculations depend on market data that may change over time
    • Actual operating expenses, lease rates, and vacancy rates may differ from market averages
    • Individual property conditions, lease terms, and tenant quality significantly impact actual NOI
    • Property value estimates are approximations and not official appraisals
    • Cap rates vary widely by market, property condition, and investment risk profile

    Professional Guidance Recommended: Before making any investment or financial decisions, consult with licensed appraisers, commercial real estate brokers, and financial advisors who can evaluate your specific property and circumstances.
    By using this feature, you acknowledge that Realmo is not responsible for investment decisions or actions taken based on these estimates.

    Cap approach

    Capitalization Method calculates value based on estimated net operating income (NOI) and applying a market-based capitalization rate (cap rate), we estimate what a typical investor might be willing to pay for it.

    Comparable approach

    Comparable estimate is based on recent sales of similar nearby properties, adjusted for factors like size, condition, and location.

    Relative

    Relative property class coefficient uses factors that account for typical price differences between various asset types (e.g., retail vs. industrial) to provide a more accurate market-aligned estimate.

    Geo

    Comparable Sales Method, enhanced by Geo coefficients — location-based adjustment factors that reflect differences in price levels across neighborhoods, cities, or regions ensuring a more accurate, market-sensitive valuation.

    Stat Estimate

    This method estimates value based on actual market adjusted recent (~5 years) sales of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all similar sales ($/sqft) are above this value
    • Range-to: 75% of all similar sales ($/sqft) are below this value
    AI Estimate

    This method estimates value based on AI market estimation of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all estimations ($/sqft) are above this value
    • Range-to: 75% of all estimations ($/sqft) are below this value
    Alternative use

    Estimate considers the property’s potential value if used for a different purpose-based on zoning, demand, and market feasibility.

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    20 Southline Avenue- Bldg. 1- Phase 1, South San Francisco, CA 94080
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