Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Back to Search
    Medical/Office Investment Opportunity Title is generated by Realmo AI

    15421 Clayton Rd St., Louis, MO

    View on Map
    Claim this Listing
    Loading data...
    Loading data...
    Loading data...
    For Lease
    Contact for pricing

    Medical/Office building for sale in desirable West County submarket.

    Type:OFFICE
    Property size:
    16,200 SF
    Lot size:
    0.41 Acres
    Added:
    Nov 24, 2025
    Days on Market:
    180
    Last Refresh:
    Apr 5 at 9:02 pm

    Property Features for 15421 Clayton Rd St.

    General Information

    Standard status
    Active
    Size
    16,200 SF
    Lot size
    0.41 Acres
    Property subtype
    OFFICE

    We can help!

    Listing Contact
    Matt J Ruck

    Listing agent Corbin P Cox

    Listing office NAI DESCO

    Listing date Nov 24, 2025

    Source Moodyscre

    Displayed information is deemed reliable but is not guaranteed and should be independently verified.

    All listing content including descriptions, pricing, images are the copyrighted material of NAI DESCO

    HighLights

    • High 8.8% Cap Rate based on current financials.
    • Prime location with easy access to Hwy 141, Clarkson Rd, and Manchester Rd in an affluent West County submarket.
    • Strong tenant mix with staggered lease expirations.
    • High‑efficiency building with solar panels, LED lighting, and modern fixtures.
    • Ample on‑site surface parking for tenants and visitors.
    • Elevator‑served for full accessibility.

    Overview

    This medical/office building presents an investment opportunity with a cap rate of 8.8% based on current financials. The property is a high-efficiency building equipped with solar panels, LED lighting, and modern fixtures. It is elevator-served, ensuring full accessibility throughout. Ample on-site surface parking is available for both tenants and visitors. The location offers convenient access to Hwy 141, Clarkson Rd, and Manchester Rd, situated in an affluent and highly desirable West County submarket. The building features a strong tenant mix with staggered lease expirations. One remaining vacancy exists, comprising 1,040 square feet in white box condition, complete with new paint, flooring, and a ceiling grid. The property has a total size of 16,200 square feet and is located at 15421 Clayton Rd, St. Louis, MO.
    Location Intelligence

    Current Use by Public Records

    Isalis (Bike/Boat/Book/etc) Store Party City Party Supply Store Skunk Funk Big Box & Wholesale Store Carl's Trading Co Hat Shop Bushka's Kitchen LLC (Bike/Boat/Book/etc) Store

    Suggested Use

    Real Estate Agency Law Firm Restaurant Spa & Massage Center Dental Office Hair Salon Nail Salon Building Supply Gym & Fitness Center Auto Repair Shop

    Zoning and permitted uses should be independently verified with local authorities.

    Similar Places Nearby

    • Kehrs Mill Veterinary Care — 15479 Clayton Rd, Ballwin, MO 63011

    Location Insight

    • Map
    • Local Demand
    City
    Louis
    County
    St. Louis
    State
    Missouri
    Longitude
    -90.1928
    Latitude
    38.6305

    Nearby Similar for Lease

    • $3,830/Mo
      2,702 SF

      Professional Office Space Available

      Office suite for lease near Westport and I-270/Page.
      2258 Schuetz Road, St Louis, MO 63146
      View Details
    • $1,600/Mo
      2,300 SF

      Historic Landmark Commercial Space

      Renovated 2300 SF space ideal for office or studio.
      3660 Gravois Avenue, St Louis, MO 63116
      View Details
    • $500/Mo
      14,256 SF

      Office Space in St Louis

      Office spaces available for lease in St Louis, MO.
      4301 Page Boulevard, St Louis, MO 63113
      View Details
    • $4,630/Mo
      3,268 SF

      Office Space in St Louis

      Professional office space for lease near I-270/Page.
      2258 Schuetz Road, St Louis, MO 63146
      View Details
    • $1,000/Mo
      900 SF

      High-Visibility Storefront in St Louis

      Functional retail space with offices, kitchen, storage, and parking.
      8206 Gravois Road, St Louis, MO 63123
      View Details
    • $14 SF/Yr
      2,859 SF

      Macklind Avenue Office Space Available

      Office space for lease in the Macklind Graphics Building.
      1327 Macklind Avenue, St Louis, MO 63110
      View Details
    • $400/Mo

      Office Spaces Near University

      Two office spaces available for lease near the University.
      7320 Florissant Road, St Louis, MO 63121
      View Details
    • $628/Mo

      Downtown St Louis Office Space

      Flexible office solutions in the heart of downtown St Louis.
      6 Cardinal Way, St Louis, MO 63102
      View Details
    • $1,000/Mo
      14,256 SF

      Sanctuary Available For Lease

      Church shared space available for lease in St. Louis.
      4301 Page, St Louis, MO 63113
      View Details
    • $400/Mo

      Retail Space in High-Traffic Area

      Retail spaces available in high-traffic St. Louis location.
      7954 N Broadway N, St Louis, MO 63147
      View Details
    • $1,500/Mo

      Retail Space in St Louis

      Recently renovated retail space suitable for various businesses.
      3355 S Jefferson Avenue, St Louis, MO 63118
      View Details
    • $1.00 SF/Yr

      Restaurant Space in Crown District

      Second generation restaurant space with potential patio access.
      4247 S Kingshighway, St Louis, MO 63110
      View Details

    FAQs

    What type of property is this?
    Medical Office Space - Medical/Office building for sale in desirable West County submarket.
    Where is this medical office space located?
    The property is located at 15421 Clayton Rd St. Louis, MO.
    What are key features of this property?
    This property features: High 8.8% Cap Rate based on current financials.; Prime location with easy access to Hwy 141, Clarkson Rd, and Manchester Rd in an affluent West County submarket.; Strong tenant mix with staggered lease expirations.
    (314) 994-4444 Call to check price and availability
    We can help!
    Contact for Pricing
    Please call us for current price
    and status of this listing
    Matt J Ruck
    Learn More
    Request Owner's contact information
    Message sent successfully
    Error
    If you are the owner or broker of this property and would like to edit or remove this listing please send a message to web site administrator.
    Message sent successfully
    Error
    Email to Your Friends
    Link copied to clipboard
    Separate multiple addresses with a comma
    Message sent successfully
    Error

    Realmo Value Estimations

    Realmo estimates a property’s market value using a proprietary methodology that incorporates public data and user-submitted information. This cumulative value is generated by integrating a variety of conventional and innovative methods. 

    Disclaimer

    These figures are not official appraisals and should not be used as a substitute for a valuation performed by a licensed appraiser.
    Actual market value may differ due to factors not captured in the data. Estimates are offered for informational purposes only, and users should conduct independent research before making financial or investment decisions.
    By using this feature, you acknowledge that Realmo is not responsible for actions taken based on these estimates.

    AI approach

    Realmo AI Method estimates property value using machine learning models trained on millions of comparable listings, transactions, and market signals. It analyzes property features, location intelligence data, and current market dynamics to predict the most probable market value in real time.

    Realmo CapRate Calculation

    Realmo calculates the Capitalization Rate (Cap Rate) to help estimate a property's potential return on investment. The Cap Rate is a fundamental metric in commercial real estate that measures the relationship between a property's net operating income and its market value.

    How We Calculate Cap Rate

    Cap Rate Formula:
    Cap Rate (%) = (Net Operating Income / Property Value) × 100

    Net Operating Income (NOI) Formula:
    NOI = Area × Lease Rate × (1 - Vacancy Rate) × (1 - Operating Expense Ratio)

    Components

    Net Operating Income (NOI) represents the annual income a property generates after operating expenses:

    • Area: Building square footage from property records
    • Lease Rate: Annual $/sqft based on market data for the property type and geographic location
    • Vacancy Rate: Percentage of unoccupied space based on market data for the property type and location
    • Operating Expense Ratio: Operating costs as a percentage of income, varies by property type

    Property Value is derived from:

    • Recent sale price (if available)
    • Statistical models using comparable sales
    • AI-powered valuation estimates

    Example Calculation

    For a 100,000 sqft Office Building:

    • Lease Rate: $25.00/sqft/year (market data for Office in this area)
    • Vacancy Rate: 8% (market data for Office in this area)
    • Operating Expense Ratio: 35% (typical for Office properties)
    • Property Value: $15,000,000

    Step 1: Calculate NOI

    NOI = 100,000 × $25.00 × (1 - 0.08) × (1 - 0.35)
    NOI = 100,000 × $25.00 × 0.92 × 0.65
    NOI = $1,495,000/year

    Step 2: Calculate Cap Rate

    Cap Rate = ($1,495,000 / $15,000,000) × 100
    Cap Rate = 9.97%

    Property Type Considerations

    Net Operating Income calculations vary by property type due to different operating expense ratios:

    • Office: Higher expenses (30-40%) for HVAC, utilities, maintenance
    • Retail: Moderate expenses (25-35%) for common area maintenance
    • Industrial/Warehouse: Lower expenses (15-25%) for minimal tenant services
    • Multifamily: Moderate expenses (35-45%) including property management
    • Self-Storage: Lower expenses (25-35%) due to minimal maintenance

    Market lease rates and vacancy rates are specific to each property type and geographic location, reflecting local market conditions.

    Disclaimer

    These calculations are estimates for informational purposes only and should not be used as a substitute for professional financial analysis or appraisal.

    • Cap Rate calculations depend on market data that may change over time
    • Actual operating expenses, lease rates, and vacancy rates may differ from market averages
    • Individual property conditions, lease terms, and tenant quality significantly impact actual NOI
    • Property value estimates are approximations and not official appraisals
    • Cap rates vary widely by market, property condition, and investment risk profile

    Professional Guidance Recommended: Before making any investment or financial decisions, consult with licensed appraisers, commercial real estate brokers, and financial advisors who can evaluate your specific property and circumstances.
    By using this feature, you acknowledge that Realmo is not responsible for investment decisions or actions taken based on these estimates.

    Cap approach

    Capitalization Method calculates value based on estimated net operating income (NOI) and applying a market-based capitalization rate (cap rate), we estimate what a typical investor might be willing to pay for it.

    Comparable approach

    Comparable estimate is based on recent sales of similar nearby properties, adjusted for factors like size, condition, and location.

    Relative

    Relative property class coefficient uses factors that account for typical price differences between various asset types (e.g., retail vs. industrial) to provide a more accurate market-aligned estimate.

    Geo

    Comparable Sales Method, enhanced by Geo coefficients — location-based adjustment factors that reflect differences in price levels across neighborhoods, cities, or regions ensuring a more accurate, market-sensitive valuation.

    Stat Estimate

    This method estimates value based on actual market adjusted recent (~5 years) sales of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all similar sales ($/sqft) are above this value
    • Range-to: 75% of all similar sales ($/sqft) are below this value
    AI Estimate

    This method estimates value based on AI market estimation of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all estimations ($/sqft) are above this value
    • Range-to: 75% of all estimations ($/sqft) are below this value
    Alternative use

    Estimate considers the property’s potential value if used for a different purpose-based on zoning, demand, and market feasibility.

    More about this property
    Thanks! Your message was sent.
    Error! Your message wasn't sent.
    Please enter your name
    Please enter email
    Please enter the email in the correct format
    Please enter phone
    Please enter the number in the correct format
    Please enter message
    Thank You

    You are Unsubscribed From Notifications

    Thank You for Inquiry
    15421 Clayton Rd, St. Louis, MO
    letter with green check mark
    Check your email
    We sent you the
    agent's contact details. yellow underline
    Can't find it?
    Please check your junk/spam folder.
    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!