Mission Street Storefront for Rent

4221 Mission St, San Francisco, CA 94112

View on Map

For Lease

$1,999 /Mo

Prime commercial space with high visibility and foot traffic.

Type:Commercial

HighLights

Prime ground‑floor commercial space on highly trafficked Mission Street.
Strong foot and vehicle traffic with excellent visibility.
Flexible open layout suitable for various retail or service uses.
Close proximity to BART, MUNI, and bus lines (Excellent Transit Score: 71).
Surrounded by dense residential and commercial uses.
High Walk Score (89) and Bike Score (75).

We can help!

Listing Contact

Wilson Yee

Learn more

For Lease

$1,999 /Mo

Prime commercial space with high visibility and foot traffic.

Type:Commercial

Added:: Apr 24, 2026
Days on Market:: 49
Last Refresh:: Apr 24 at 5:56 pm

Property Features for 4221 Mission St

General Information

Standard status: Active
Property subtype: Commercial

Building Details

Year Built: 1977

We can help!

Listing Contact

Wilson Yee

Listing agent Wilson Yee

Listing office

Listing date Apr 24, 2026

Source Elliman

Displayed information is deemed reliable but is not guaranteed and should be independently verified.

All listing content including descriptions, pricing, images are the copyrighted material of Wilson Yee

HighLights

Prime ground‑floor commercial space on highly trafficked Mission Street.
Strong foot and vehicle traffic with excellent visibility.
Flexible open layout suitable for various retail or service uses.
Close proximity to BART, MUNI, and bus lines (Excellent Transit Score: 71).
Surrounded by dense residential and commercial uses.
High Walk Score (89) and Bike Score (75).

Overview

This ground-floor commercial space is available for rent along the highly trafficked Mission Street corridor. The storefront benefits from excellent visibility, strong pedestrian activity, and convenient access to public transportation. The space features a wide frontage, large display windows, and an efficient open layout. It is suitable for a variety of neighborhood-serving retail or service uses. Located in a dense residential and commercial area, the property benefits from consistent foot traffic and nearby amenities. It is ideal for retail, personal services, professional offices, or other permitted commercial uses. The location offers close proximity to BART, MUNI, and bus lines. The bike score is 75, indicating it is very bikeable. The walk score is 89, indicating it is very walkable. The transit score is 71, indicating excellent transit.

Location Intelligence

Current Use by Public Records

Octavio Ramirez - State ... Insurance Agency D & S Financial ... Tax Preparation Pestec Garden Center

Suggested Use

Similar Places Nearby

beija flor gallery — 4786 Mission St, San Francisco, CA 94112
John David Florist - Flower Delivery San Francisco CA — 4773 Mission St, San Francisco, CA 94112, United States
Glen Park Flower Stand — 2901 diamond st, san francisco, ca 94131
Black Lockett Florals and Foliages — 409 Cortland Ave, San Francisco, CA 94110

Location Insight

Map
Local Demand

City: San Francisco
County: San Mateo
State: California
Longitude: -122.429944
Latitude: 37.729579

Nearby Similar for Lease

$2,400/Mo

547 SF

Turnkey Medical Office Suite

Professional office suite in premier medical building, Union Square.

490 Post Street 1554, San Francisco, CA 94102

View Details
$6,500/Mo

592 SF

Retail Storefront in San Francisco

Newly constructed retail space with modern design and great street presence.

1525 Franklin Street, San Francisco, CA 94109

View Details
$30 SF/Yr

1,000 SF

Mission District Retail Space Available

Prime retail space in vibrant Mission District location for lease.

3327 24th Street, San Francisco, CA 94110

View Details
$2,500/Mo

1,190 SF

Streetfront Retail Storefront

Retail storefront on a high-visibility street directly in front of a busy bus stop.

5654 Mission Street, San Francisco, CA 94112

View Details
$3,800/Mo

Ground-Floor Retail Storefront

Ground-floor retail space with large display windows, restroom, and street-facing signage on a neighborhood commercial corridor.

1226 Pacific Ave, SAN FRANCISCO, CA 94109

View Details
$39 SF/Yr

2,000-2,100 SF

Versatile Space on Taraval Street

Adaptable space for medical, dental, retail use in San Francisco.

2143-2145 Taraval St, San Francisco, CA 94112

View Details
Sponsored

$129-$7,948/Mo

11-1,292 SF

CA, San Francisco - 101 Montgomery

101 Montgomery St, Unit 900, San Francisco, CA 94111

View Details
$129-$235/Mo

54-108 SF

CA, San Francisco - 720 Market St

720 Market St, San Francisco, CA 94210

View Details
$8,000/Mo

3,795 SF

San Francisco Commercial Space Available

Two-story commercial building in Lower Nob Hill for rent.

729 Bush Street, San Francisco, CA 94108

View Details
$129-$10,166/Mo

11-1,292 SF

Spaces Mission & 3rd

95 3Rd St, San Francisco, CA 94103

View Details
$129-$5,116/Mo

11-1,292 SF

Spaces Levi's Plaza

1160 Battery St, San Francisco, CA 94111

View Details
$129-$6,436/Mo

11-1,292 SF

California Street

50 California St, Unit 1500, San Francisco, CA 94111

View Details

For lease
Storefront properties
CA
San Francisco
94112
4221 Mission St

What type of property is this?

Storefront property - Prime commercial space with high visibility and foot traffic.

Where is this storefront property located?

The property is located at 4221 Mission St San Francisco, CA.

What is the lease rate?

The lease rate is $1,999 /Mo.

What are key features of this property?

This property features: Prime ground‑floor commercial space on highly trafficked Mission Street.; Strong foot and vehicle traffic with excellent visibility.; Flexible open layout suitable for various retail or service uses.