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    GMP Biomanufacturing Facility for Lease Title is generated by Realmo AI

    535 Science Drive, Madison, WI 53711

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    Turnkey 41,000 SF GMP-compliant biomanufacturing facility in Madison, WI.

    Type:LifeSciences
    Property size:
    41,000 SF
    Added:
    Mar 25, 2026
    Days on Market:
    68
    Last Refresh:
    Mar 18 at 8:28 am

    Property Features for 535 Science Drive

    General Information

    Standard status
    Active
    Size
    41,000 SF
    Property subtype
    LifeSciences

    We can help!

    Listing Contact
    Chase Brieman
    Chase Brieman

    Listing agent Chase Brieman License #54278

    Listing office CBRE - Madison

    Listing date Mar 25, 2026

    Source Cbre

    Displayed information is deemed reliable but is not guaranteed and should be independently verified.

    All listing content including descriptions, pricing, images are the copyrighted material of CBRE - Madison

    HighLights

    • Turnkey, GMP‑compliant biomanufacturing facility (41,000 sq ft) ready for immediate operation.
    • Validated cold storage with three mapped 2–8°C cold rooms and redundant systems.
    • Five ISO‑7 cleanrooms (6,000 sq ft) with advanced HVAC (MERV 14 + HEPA), airlocks, and differential pressure sensors.
    • On‑site BSL‑2 and QC laboratories located within the cleanroom boundary.
    • Robust shipping/receiving infrastructure with temperature‑controlled dual docks and secure material flow.
    • Strategic location in Madison, WI, a thriving bioscience hub with a strong economy and a highly educated workforce.

    Overview

    The property at 535 Science Drive, Madison, WI, is a 41,000-square-foot GMP-compliant biomanufacturing facility. It offers a solution for life sciences companies seeking infrastructure in a strategic location. The facility features five ISO-7 cleanrooms totaling 6,000 square feet, equipped with airlocks, differential pressure sensors, epoxy finishes, and advanced HVAC systems with MERV 14 and HEPA filtration delivering 30–40 air changes per hour. ISO-8 spaces are supported with 20 ACH. The facility includes BSL-2 and QC laboratories within the cleanroom boundary, offering clean air, robust power capacity, and proximity to EM and specialty labs. Office and amenity spaces are modern and thoughtfully designed, including conference rooms, reception areas, and support zones. Validated cold storage is available, with three mapped 2–8°C cold rooms supported by redundant systems. The shipping and receiving infrastructure features temperature-controlled dual docks, secure material flow pathways, and a high-bay warehouse with both ambient and cold storage capabilities.
    Property Profile Location Intelligence

    Current Use by Public Records

    Manufacturing properties

    Suggested Use

    Real Estate Agency Law Firm Restaurant Spa & Massage Center Dental Office Hair Salon Nail Salon Building Supply Gym & Fitness Center Auto Repair Shop

    Zoning and permitted uses should be independently verified with local authorities.

    Location Insight

    • Map
    • Local Demand
    City
    Madison
    County
    Dane
    State
    Wisconsin
    Longitude
    -89.4669742
    Latitude
    43.0566456

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    FAQs

    What type of property is this?
    Manufacturing property - Turnkey 41,000 SF GMP-compliant biomanufacturing facility in Madison, WI.
    Where is this manufacturing property located?
    The property is located at 535 Science Drive Madison, WI.
    What are key features of this property?
    This property features: Turnkey, GMP‑compliant biomanufacturing facility (41,000 sq ft) ready for immediate operation.; Validated cold storage with three mapped 2–8°C cold rooms and redundant systems.; Five ISO‑7 cleanrooms (6,000 sq ft) with advanced HVAC (MERV 14 + HEPA), airlocks, and differential pressure sensors.
    (608) 441-7571
    We can help!
    Listing Contact
    Chase Brieman
    Chase Brieman
    Real Estate License ID: 54278
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    Realmo Value Estimations

    Realmo estimates a property’s market value using a proprietary methodology that incorporates public data and user-submitted information. This cumulative value is generated by integrating a variety of conventional and innovative methods. 

    Disclaimer

    These figures are not official appraisals and should not be used as a substitute for a valuation performed by a licensed appraiser.
    Actual market value may differ due to factors not captured in the data. Estimates are offered for informational purposes only, and users should conduct independent research before making financial or investment decisions.
    By using this feature, you acknowledge that Realmo is not responsible for actions taken based on these estimates.

    AI approach

    Realmo AI Method estimates property value using machine learning models trained on millions of comparable listings, transactions, and market signals. It analyzes property features, location intelligence data, and current market dynamics to predict the most probable market value in real time.

    Realmo CapRate Calculation

    Realmo calculates the Capitalization Rate (Cap Rate) to help estimate a property's potential return on investment. The Cap Rate is a fundamental metric in commercial real estate that measures the relationship between a property's net operating income and its market value.

    How We Calculate Cap Rate

    Cap Rate Formula:
    Cap Rate (%) = (Net Operating Income / Property Value) × 100

    Net Operating Income (NOI) Formula:
    NOI = Area × Lease Rate × (1 - Vacancy Rate) × (1 - Operating Expense Ratio)

    Components

    Net Operating Income (NOI) represents the annual income a property generates after operating expenses:

    • Area: Building square footage from property records
    • Lease Rate: Annual $/sqft based on market data for the property type and geographic location
    • Vacancy Rate: Percentage of unoccupied space based on market data for the property type and location
    • Operating Expense Ratio: Operating costs as a percentage of income, varies by property type

    Property Value is derived from:

    • Recent sale price (if available)
    • Statistical models using comparable sales
    • AI-powered valuation estimates

    Example Calculation

    For a 100,000 sqft Office Building:

    • Lease Rate: $25.00/sqft/year (market data for Office in this area)
    • Vacancy Rate: 8% (market data for Office in this area)
    • Operating Expense Ratio: 35% (typical for Office properties)
    • Property Value: $15,000,000

    Step 1: Calculate NOI

    NOI = 100,000 × $25.00 × (1 - 0.08) × (1 - 0.35)
    NOI = 100,000 × $25.00 × 0.92 × 0.65
    NOI = $1,495,000/year

    Step 2: Calculate Cap Rate

    Cap Rate = ($1,495,000 / $15,000,000) × 100
    Cap Rate = 9.97%

    Property Type Considerations

    Net Operating Income calculations vary by property type due to different operating expense ratios:

    • Office: Higher expenses (30-40%) for HVAC, utilities, maintenance
    • Retail: Moderate expenses (25-35%) for common area maintenance
    • Industrial/Warehouse: Lower expenses (15-25%) for minimal tenant services
    • Multifamily: Moderate expenses (35-45%) including property management
    • Self-Storage: Lower expenses (25-35%) due to minimal maintenance

    Market lease rates and vacancy rates are specific to each property type and geographic location, reflecting local market conditions.

    Disclaimer

    These calculations are estimates for informational purposes only and should not be used as a substitute for professional financial analysis or appraisal.

    • Cap Rate calculations depend on market data that may change over time
    • Actual operating expenses, lease rates, and vacancy rates may differ from market averages
    • Individual property conditions, lease terms, and tenant quality significantly impact actual NOI
    • Property value estimates are approximations and not official appraisals
    • Cap rates vary widely by market, property condition, and investment risk profile

    Professional Guidance Recommended: Before making any investment or financial decisions, consult with licensed appraisers, commercial real estate brokers, and financial advisors who can evaluate your specific property and circumstances.
    By using this feature, you acknowledge that Realmo is not responsible for investment decisions or actions taken based on these estimates.

    Cap approach

    Capitalization Method calculates value based on estimated net operating income (NOI) and applying a market-based capitalization rate (cap rate), we estimate what a typical investor might be willing to pay for it.

    Comparable approach

    Comparable estimate is based on recent sales of similar nearby properties, adjusted for factors like size, condition, and location.

    Relative

    Relative property class coefficient uses factors that account for typical price differences between various asset types (e.g., retail vs. industrial) to provide a more accurate market-aligned estimate.

    Geo

    Comparable Sales Method, enhanced by Geo coefficients — location-based adjustment factors that reflect differences in price levels across neighborhoods, cities, or regions ensuring a more accurate, market-sensitive valuation.

    Stat Estimate

    This method estimates value based on actual market adjusted recent (~5 years) sales of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all similar sales ($/sqft) are above this value
    • Range-to: 75% of all similar sales ($/sqft) are below this value
    AI Estimate

    This method estimates value based on AI market estimation of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all estimations ($/sqft) are above this value
    • Range-to: 75% of all estimations ($/sqft) are below this value
    Alternative use

    Estimate considers the property’s potential value if used for a different purpose-based on zoning, demand, and market feasibility.

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