355 South Main Street Greenville, SC 29601

Spaces For Lease

at 355 South Main Street Contact us

Listing office CBRE | Greenville b***@cbre.com Show Phone

Listing date Nov 22, 2025

Source Cbre

Displayed information is deemed reliable but is not guaranteed and should be independently verified.

All listing content including descriptions, pricing, images are the copyrighted material of CBRE | Greenville

Report an issue

---

Investment Insights

Based on property information with market context.

This office space offers a fully furnished environment with a double-door glass entrance. The 5692-square-foot layout includes a mix of private offices, conference rooms, open space, and a large break room. The property is located at 355 South Main Street, Greenville, SC, 29601.

Key Highlights

• Move‑in ready condition
• Fully furnished
• Mix of private offices, conference rooms, and open space

Property Analytics

Property Profile Location Intelligence

Similar For Rent Nearby

• 

  $1,500/Mo

  Lower-Level Office Suite

  Lower-level office/studio space with one bath in Park Square Center, freshly painted and ready for occupancy.

  1322 E Washington Street, Greenville, SC 29607

  View Details
• 

  $550/Mo

  Main Street Professional Office Space

  Newly renovated office spaces overlooking Main Street in Greenville, SC.

  200 N Main Street, Greenville, SC 29601

  View Details
• 

  $3,800/Mo

  2,000 SF

  High-Visibility Commercial Site on White Horse

  One-acre commercial site ideal for auto sales or similar uses.

  4707 White Horse Road, Greenville, SC 29611

  View Details
• 

  $2,750/Mo

  Renovated Office Suite with ADA Access

  Newly renovated office suite offers two private offices, two conference rooms, reception, and an ADA bathroom.

  413 Vardry Street, Greenville, SC 29601

  View Details
• 

  $2,550/Mo

  Updated Office Suite with Parking

  Updated office suite with vaulted ceilings, exposed ductwork, multiple private offices, and five dedicated parking spaces.

  413 Vardry Street, Greenville, SC 29601

  View Details
• 

  $19 SF/Yr

  3,309 SF

  Turn-Key Retail Space at Intersection

  Recently upgraded retail building with flexible, tenant-customizable buildouts and full-service rental terms.

  33 Villa Rd, Greenville, SC 29615

  View Details
• Sponsored

  

  $129-$24,365/Mo

  11-2,123 SF

  SC, Greenville - E Stone Avenue

  17 1St St, Unit 2ND, Greenville, SC 29609

  View Details
• 

  $129-$21,652/Mo

  11-2,174 SF

  Millport at Butler

  128 Millport Cir, Unit 200, Greenville, SC 29607

  View Details
• 

  $129-$22,570/Mo

  11-2,002 SF

  NOMA Tower

  220 Main St, Unit 500, Greenville, SC 29601

  View Details
• 

  $800/Mo

  All-Brick One-Level Office Building

  All-brick, one-level office space with multiple window offices and a bright, naturally lit lobby.

  413 Vardry Street, Greenville, SC 29601

  View Details
• 

  $18 SF/Yr

  2,336 SF

  Medical Office Suite with Reception

  New LVP flooring supports a patient-ready layout with reception, private offices, and accessible restrooms.

  30 Memorial Medical Dr, Greenville, SC 29605

  View Details
• 

  $16.50 SF/Yr

  4,000 SF

  Single-Story Freestanding Office Building

  Functional single-story office layout with multiple private offices, open bullpen space, conference room, and on-site parking.

  1313A Miller Road, Greenville, SC 29607

  View Details

FAQs

What type of property is this?

Office units - Move-in ready, furnished office space with private offices and conference rooms.

Where is this office units located?

The property is located at 355 South Main Street Greenville, SC.

What is the lease rate?

The lease rate is $47.50 SF/Yr.

What are key features of this property?

This property features: Move‑in ready condition; Fully furnished; Mix of private offices, conference rooms, and open space