Lancaster, SC Commercial Real Estate for Sale

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57 properties

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Updated: May 28

Prime Development Land Lancaster, SC

2383 Charlotte Highway, Lancaster, SC 29720

$2,200,000

15.55 AC lot

Prime development opportunity on Charlotte Hwy/Hwy 521, Lancaster County's fastest‑growing corridor.
Zoned General Business with a high daily traffic count of 27,500.
Located beside Lancaster Medical Park and surrounded by new residential communities.
Proximity to major upcoming developments: Lennar Homes' Roselyn Community (1.3 miles) and DR Horton's New Community (0.5 miles).
Total of 15.55 acres (8.88 Acres & 6.67 Acres) with 463 feet of road frontage.

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Updated: May 15

Vacant Storefront Building

401 E Gay Street, Lancaster, SC 29720

$139,999

0.12 AC lot

Storefront building constructed in 1960
Vacant for approximately one year
0.12‑acre lot
Parking lot included with the property
Parking area located beside the barbershop

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Commercial Land Near Planned Intersection

Charlotte Hwy lot: 2, Lancaster, SC 29720

$2,500,000

18.00 AC lot

Land positioned for commercial planning subject to county approval and verification of access, utilities, and permitted uses.

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NNN Automotive Property

1878 Great Falls Hwy, Lancaster, SC 29720

$1,400,000

7,000 sqft

Net-leased automotive retail property with a corporate guarantee and more than seven years remaining on the lease.

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General Business Development Land

2383 Charlotte Highway, Lancaster, SC 29720

$2,200,000

15.55 AC lot

Two-parcel tract with 463 feet of road frontage on Charlotte Highway, positioned beside Lancaster Medical Park in a growing residential corridor.

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Fenced Agricultural Land

1049 Culp Ferguson Road, Lancaster, SC 29720

$2,775,000

84.67 AC lot

Fenced farmland features open fields, pastures, wooded buffers, rolling terrain, and a pond.

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Rolling Farmland with Barn

992 S Potter Road, Lancaster, SC 29720

$799,900

39.80 AC lot

Nearly 40 acres of rolling farmland with a barn featuring an elevator and two ponds, zoned LDR.

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Commercial Building with Fenced Parking

305 E Arch Street #36, Lancaster, SC 29720

$250,000

1,653 sqft

Commercial building with open area, offices, and parking.

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Farmland Tract with Road Frontage

6327 Witherspoon Trail, Lancaster, SC 29720

$625,000

19.32 AC lot

Zoned RN farmland tract with county water available and septic needed, plus natural water features along the property.

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Wooded Acreage with Open Areas

Bath Lane, Lancaster, SC 29720

$199,500

11.12 AC lot

11.12-acre parcel with mature trees and open areas, offering flexibility for residential, agricultural, or recreational use.

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Retail Buildings For Sale

1317 Hwy 9 ByPass W, Lancaster, SC 29720

$550,000

2,100 sqft

Two commercial buildings for sale in a growing area.

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Two-Building Medical Office Property

1201 Colonial Commons Court, Lancaster, SC 29720

$975,000

0.82 AC lot

Professional office compound with medical layouts, reception areas, waiting rooms, and separate work areas across two buildings.

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Land For Sale, Lancaster SC

10129 Lakeshore Drive, Lancaster, SC 29720

$75,000

0.47 AC lot

Commercial land available in Lancaster, South Carolina.

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Specialty Property for Sale

209 W Barr Street, Lancaster, SC 29720

$218,000

1,208 sqft

Specialty property for sale in Lancaster County, with directions available via Main St and W Barr St.

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Land, Lancaster, SC

329 Pineview Court Lane, Lancaster, SC 29720

$115,000

3.05 AC lot

Agricultural land / Farmland · 3.05 Acres

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Brick Storefront Property

2836 Lynwood Drive, Lancaster, SC 29720

$149,900

0.47 AC lot

Commercial space with central air, electric heat, carpet flooring, and a bathroom.

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Thriving Child Development Center

1699 N Rocky River Road, Lancaster, SC 29720

$3,200,000

9,648 sqft

Child development center with two buildings and outdoor playground.

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Commercial Land on Corner Lot

S Main Street, Lancaster, SC 29720

$272,500

1.81 AC lot

Corner lot commercial land with road frontage and utilities.

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Historic Mixed-Use Retail/Office Buildings

209-227 S. Main Street, Lancaster, SC 29720

Contact for pricing

29,151 sqft

Vacant 1930s buildings offer retail or office space and renovation opportunity in downtown Lancaster, South Carolina.

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Corner Commercial Land

Hwy 200 Bypass, Lancaster, SC 29720

$392,000

3.14 AC lot

Three adjoining lots offer commercial land with public water and sewer at a multi-lane intersection.

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Downtown Mixed-Use Building for Renovation

229 S. Main Street, Lancaster, SC 29720

Contact for pricing

15,266 sqft

Vacant 1930s mixed-use property in downtown Lancaster, built for retail or office re-activation with renovation underway.

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Downtown Mixed-Use Redevelopment Property

210 S. White Street, Lancaster, SC 29720

Contact for pricing

22,251 sqft

Vacant 1930s retail/office buildings in downtown Lancaster offer a renovation-ready canvas for mixed-use redevelopment.

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1930s Retail/Office Building Portfolio

116 Arch Street, Lancaster, SC 29720

Contact for pricing

29,444 sqft

Vacant, renovation-needed buildings offering flexible retail or office space in downtown Lancaster with convenient highway access.

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Office Building

312 N Main Street N, Lancaster, SC 29720

Contact for pricing

2,706 sqft

Office building with some furnishings staying, and utility split where tenant pays electricity and natural gas.

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Lancaster, SC Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in Lancaster, SC, showcased through 57 active listings on our real estate platform. These investment opportunities span a total of 500,207 square feet of properties for sale, with an estimated market value of $26,976,053.

Sale prices for business properties in Lancaster, SC start at $75,000, averaging $817,456, and reaching up to $3,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 52K

Population Growth (5Y) +8.0%

Median Household Income $59,039

College Educated 9.5%

High-Yield Neighborhoods for Investment

Identify Lancaster submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
Lancaster	$797.5K
Fort Mill	$2M

Taxes & Financing

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Lancaster County

New Delisted

Property Size Breakdown

The majority of commercial real estate listings in Lancaster fall within the 5,000 to 10,000 square foot range.

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