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Two-Story Live-Work Building with Apartment
For Sale
$475,000

421 W Twohig Avenue, San Angelo, TX 76903

COMMERCIAL - San Angelo, TX

Property Size4,366 SF
Lot Size0.36 Acres
Price / SF$108.80
Days on Market20

Property Features for 421 W Twohig Avenue

General Information

Property type Commercial Sale
Property subtype Office
Zoning description General Commercial
Parking features Carport, On Street, Driveway
Subdivision San Angelo
Standard status Active
APN 23-41700-0300-013-00
Size 4,366 SF
Lot size 0.36 Acres

Taxes and HOA fees

Tax Description Acres: 0.364 Lot: 15 & E33.5 Of 14 Blk: 30 Subd: San Angelo Addition
Legal Description Acres: 0.364 Lot: 15 & E33.5 Of 14 Blk: 30 Subd: San Angelo Addition

Utilities

Sewer type Public Sewer
Heating system Electric (Heating), Forced Air, Central
Cooling system Electric, Central Air
Water source Public

Building Details

Year built 1962
Floors in Building 2
Flooring type Wood, Tile, Carpet
Building materials Brick
Roof type Composition, Metal
Listing Agency: Keller Williams Synergy · Keller Williams Realty
Listed By: Danielle Ellise Group
Added: Jul 24 Changed: Aug 4 Last Checked: Aug 12 at 1:06AM
MLS# 201758

Copyright © 2026 San Angelo Association of Realtors. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified.

Investment Insights

Based on property information with market context.

Located at 421 W Twohig Avenue in San Angelo, this two-story live-work building combines commercial and residential use in a single structure. The property includes an apartment upstairs, while the main level offers space for a variety of business ventures. Interior details include soaring ceilings, exquisite millwork, and a prominent staircase, supporting the building’s distinct historic character.

Exterior features include a wraparound porch and patio areas upstairs and downstairs, along with a rear carport that provides convenient parking plus separate storage. The lot size is approximately 0.36 acres, with a total building size of 4,366 square feet.

For buyers considering renovations or exterior improvements, the remarks note potential TIRZ funding through the City of San Angelo for qualifying exterior work and possible qualification for Texas state historic tax credits. This combination of flexible layout and period character can fit a range of owner-user and investor strategies.

Key Highlights

  • Two‑story brick building built in 1962 with historic architectural details including soaring ceilings and a staircase
  • Mixed‑use design with an apartment upstairs and flexible main‑level space for commercial or residential use
  • Wraparound porch plus patio areas upstairs and downstairs

Property Analytics

Current Use

Anderson Thomas F ... Dental Office

Suggested Use

Top Pick Parking Lot & Garage Dental Office (Bike/Boat/Book/etc) Store Veterinary Clinic Catering Service Daycare Center

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Location Intelligence

Trade Area within ½ mile

1,927
Businesses Nearby

Demographics for 76903, TX

32,215
Population
14,169
Households
2.3
Avg Household Size
37
Median Age
16%
College-Educated
78%
High-School Grad
25.0 sq mi
ZIP Area
1,289
Density / Sq Mi
$49,045
Median Household Income
$33,077
Median Earnings
$1,051
Median Rent
$115,900
Median Home Value

Market

Vacancy Rate% for Office in South region

14.4% 2019
16.4% 2020
17.3% 2021
18% 2022
18.6% 2023
20.3% 2024
20.2% 2025
Rey
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Frequently Asked Questions

What type of property is this?
Live-work space - Two-story building with a commercial main level and an apartment upstairs, plus a wraparound porch and rear carport parking.
Where is this live-work space located?
The property is located at 421 W Twohig Avenue San Angelo, TX.
What is the asking price?
The asking price for this property is $475,000.
What are key features of this property?
This property features: Two‑story brick building built in 1962 with historic architectural details including soaring ceilings and a staircase; Mixed‑use design with an apartment upstairs and flexible main‑level space for commercial or residential use; Wraparound porch plus patio areas upstairs and downstairs
More about this property
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