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Knoxville, PA Commercial Real Estate for Sale

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Commercial Property on Route 49
$119,000
0.19 Acres

Commercial Property on Route 49

5036 Route 49, Knoxville, PA 16928

Commercial property with endless potential on Route 49, Knoxville, PA.

  • Prime location on Route 49 in Knoxville.
  • Suitable for a variety of business ventures (hobby garage, repair shop, turnkey operation).
  • Building has great curb appeal and is larger than it appears.
  • Includes a 1962 VW Berry car, 1992 homemade car trailer, and 60‑gallon air compressor.
  • Heating system uses forced air and natural gas.
Updated: Aug 19, 2025
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Based on your search, we've compiled 45 Potential Opportunities for your consideration. Besides 1 Active listings in Knoxville, PA, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 40 Off-Market properties to explore as potential leads

Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Land with Mountain Views
$175,500
29.25 Acres

Land with Mountain Views

29.25-acre parcel with mountain views, ideal for a hobby farm.

Meak Rd, Westfield, PA 16950
View details
Westfield Car Wash Business Opportunity
$225,000
0.82 Acres

Westfield Car Wash Business Opportunity

Car wash business for sale in downtown Westfield, Pennsylvania.

121 Riv Rd, Westfield, PA 16950
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Historic Building with Brew House
$375,000
0.11 Acres

Historic Building with Brew House

Renovated historic building with brew house and apartments for sale.

204 W Main St, Elkland, PA 16929
View details
Renovated Two-Unit Multifamily Property
$189,900
0.53 Acres

Renovated Two-Unit Multifamily Property

Well-maintained, renovated two-unit multifamily property on over half acre.

109 E Main St, Elkland, PA 16920
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Explore Off-Market Properties in Knoxville, PA

Consider similar Off-Market properties in Knoxville, PA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

206 1st St

206 1st St

WAREHOUSE, STORAGE • 19,989 SF
Value Estimation
$385,000
206 1st St, Knoxville, PA 16928-9515
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5487 Rte 49

5487 Rte 49

MINI-WAREHOUSE, STORAGE • 3,300 SF
Value Estimation
$180,000
5487 Rte 49, Knoxville, PA 16928
View details
314 Water St

314 Water St

MANUFACTURING (LIGHT) • 15,646 SF
Value Estimation
$385,000
314 Water St, Knoxville, PA 16928-9702
View details
4410 Rte 49

4410 Rte 49

MINI-WAREHOUSE, STORAGE • 19,650 SF
Value Estimation
$440,000
4410 Rte 49, Knoxville, PA 16928-9645
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117 Main St

117 Main St

PROCESSING PLANT (CEMENT, GRAVEL) • 8,327 SF
Value Estimation
$200,000
117 Main St, Knoxville, PA 16928-9788
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102 Railroad Ave

102 Railroad Ave

WAREHOUSE, STORAGE • 20,375 SF
Value Estimation
$45,000
102 Railroad Ave, Knoxville, PA 16928-9603
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105 Main St

105 Main St

OFFICE/RESIDENTIAL (MIXED USE) • 4,080 SF
Value Estimation
$195,000
105 Main St, Knoxville, PA 16928
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5596 Rte 49

5596 Rte 49

VEHICLE SALES, RENTALS • 22,500 SF
Value Estimation
$330,000
5596 Rte 49, Knoxville, PA 16928-9418
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103 1st St

103 1st St

OFFICE/RESIDENTIAL (MIXED USE) • 5,160 SF
Value Estimation
$220,000
103 1st St, Knoxville, PA 16928
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113 Water St

113 Water St

RETAIL STORES (PERSONAL SERVICES) • 1,080 SF
Value Estimation by Request
113 Water St, Knoxville, PA 16928-9712
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102 Railroad Ave

102 Railroad Ave

COMMERCIAL (GENERAL) • 1,700 SF
Value Estimation
$60,000
102 Railroad Ave, Knoxville, PA 16928-9603
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102 Main St

102 Main St

FINANCIAL BUILDING • 2,173 SF
Value Estimation
$355,000
102 Main St, Knoxville, PA 16928-9745
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Locey Crk Rd

Locey Crk Rd

COMMERCIAL (GENERAL) • 0.49 Acres
Value Estimation by Request
Locey Crk Rd, Knoxville, PA 16928
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110 Main St

110 Main St

PROFESSIONAL CLUBS/ASSOCIATIONS • 2,250 SF
Value Estimation
$360,000
110 Main St, Knoxville, PA 16928
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211 Main St

211 Main St

RETAIL STORES (PERSONAL SERVICES) • 2,680 SF
Value Estimation
$320,000
211 Main St, Knoxville, PA 16928-9714
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4313 Rte 49

4313 Rte 49

AUTO REPAIR, GARAGE • 2,868 SF
Value Estimation by Request
4313 Rte 49, Knoxville, PA 16928-9638
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Main St

Main St

COMMERCIAL (GENERAL) • 960 SF
Value Estimation by Request
Main St, Knoxville, PA 16928
View details
5587 Rte 49

5587 Rte 49

AUTO REPAIR, GARAGE • 2,184 SF
Value Estimation
$80,000
5587 Rte 49, Knoxville, PA 16928-9419
View details
112 Main St

112 Main St

OFFICE (GENERAL) • 648 SF
Value Estimation
$45,000
112 Main St, Knoxville, PA 16928-9744
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127 Main St

127 Main St

OFFICE/RESIDENTIAL (MIXED USE) • 5,880 SF
Value Estimation by Request
127 Main St, Knoxville, PA 16928
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1156 Boatman Rd

1156 Boatman Rd

COMMERCIAL (GENERAL) • 330 SF
Value Estimation by Request
1156 Boatman Rd, Knoxville, PA 16928
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111  St

111 St

OFFICE/RESIDENTIAL (MIXED USE) • 4,996 SF
Value Estimation
$365,000
111 St, Knoxville, PA 16928-9700
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10737 Rte 249

10737 Rte 249

CONVENIENCE STORE • 2,035 SF
Value Estimation
$190,000
10737 Rte 249, Knoxville, PA 16928-9693
View details

Knoxville, PA Commercial Real Estate Investment Opportunities Market Analysis

Explore 32 commercial real estate investment opportunities in Knoxville, PA on our commercial real estate marketplace. The current inventory includes 806,940 square feet of properties with an estimated value of $6,434,000.

Estimated prices for commercial real estate in Knoxville, PA begin at $50,000, with an average of $279,739 and extend to $1,470,000.

In Knoxville, PA, current investment values show:

  • Retail properties positioned at $385,500
  • Industrial properties measuring $250,000
  • Individual retail properties assessed at $489,000
  • Investment properties calculated at $249,000
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