Sign Up Successful!
You now have access to more from Realmo!
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Adrian, MI Commercial Real Estate for Lease

    14 results
    List
    Map
    Renovated Office Space in Adrian
    $1,400 / Mo
    1,212 SF

    Renovated Office Space in Adrian

    115 N Main St, Adrian, MI 49221

    Newly renovated office space with convenient parking and updated features.

    • Newly renovated office space.
    • Features a reception area.
    • Ample sized offices.
    • Includes a Michigan Barrier Free lavatory.
    • Benefit from the side entrance with access to the rear municipal parking lot.
    Updated: Oct 24, 2025
    View details
    Equipped Space for Wellness Provider
    $900 / Mo
    1,716 SF

    Equipped Space for Wellness Provider

    750 High St, Adrian, MI 49221

    Fully equipped space ideal for wellness providers in Adrian, MI.

    • Fully equipped space ideal for various wellness practices (massage, lash, coaching, counseling, acupuncture, general office).
    • Utilities included in the rental price.
    • Supportive and professional environment fostering collaboration.
    • Private room with sink.
    • Large parking lot available.
    Updated: Nov 8, 2025
    View details
    Turnkey Restaurant Space in Adrian
    $1,500 / Mo
    1,763 SF

    Turnkey Restaurant Space in Adrian

    Turnkey restaurant space for lease in downtown Adrian.

    125 E Maumee St, Adrian, MI 49221
    View details
    Downtown Adrian Office Space Available
    $1,150 / Mo
    1,332 SF

    Downtown Adrian Office Space Available

    Office space near downtown Adrian with reception and private offices.

    111 N Main St, Adrian, MI 49221
    View details
    Adrian Retail Space - High Traffic Area
    $11 SF/Yr
    18,800 SF

    Adrian Retail Space - High Traffic Area

    Three suites available, 1,600-2,400 sq ft

    1114 Winter St, Adrian, MI 49221
    View details
    Adrian Retail Space For Lease
    Contact for pricing
    5,280 SF

    Adrian Retail Space For Lease

    Prime Adrian storefront, flexible space available.

    217 Hwy 223, Adrian, MI 49221
    View details
    Adrian Hwy Warehouse - Huge Potential
    $4 SF/Yr
    9,758 SF

    Adrian Hwy Warehouse - Huge Potential

    9,758 SF Warehouse, 6.21 Acres

    3131 Adrian Hwy, Adrian, MI 49221
    View details
    Adrian Retail Center: Prime Location
    Contact for pricing
    8,233 SF

    Adrian Retail Center: Prime Location

    8,233 SF Retail Space Available

    1407 Maumee St, Adrian, MI 49221
    View details
    Adrian Medical Office Suites
    $13 SF/Yr
    18,048 SF

    Adrian Medical Office Suites

    Prime Adrian location, 4,329 SF available.

    770 Riverside Ave, Adrian, MI 49221
    View details
    Retail Space on US-223
    $12 SF/Yr
    1,633 SF

    Retail Space on US-223

    Retail space available in Eastpointe Plaza, Adrian, Michigan.

    1675-1693 Us-223, Adrian, MI
    View details
    Retail Space with Drive-Thru
    $13 SF/Yr
    2,800 SF

    Retail Space with Drive-Thru

    End-cap retail space with drive-thru window and high visibility.

    1325 N Main St, Adrian, MI 49221
    View details
    Retail Space Near High-Traffic Location
    $2,500 / Mo
    3,294 SF

    Retail Space Near High-Traffic Location

    3,294 SF retail space with high visibility and traffic.

    2982 W Beecher Rd, Adrian, MI 49221
    View details
    Industrial Warehouse Space Available
    $7,500 / Mo
    16,000 SF

    Industrial Warehouse Space Available

    16,000 SF warehouse space for lease in Adrian, MI.

    540 S Center St, Adrian, MI 49221
    View details
    Restaurant Space with Liquor License
    $20 SF/Yr
    1,800 SF

    Restaurant Space with Liquor License

    Restaurant space with full buildout and liquor license available.

    2070 E Us Highway 223, Adrian, MI 49221
    View details
    Based on your search, we've compiled 46 Potential Opportunities for your consideration. Besides 14 Active listings in Adrian, MI, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 28 Properties for Sales.

    Explore Commercial Real Estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Former Bank Building Available
    $305,000
    3,337 SF

    Former Bank Building Available

    Vacant bank building with drive-thru and vault.

    616 W Adrian St, Blissfield, MI 49228
    View details
    Former Bank Building Available
    $305,000

    Former Bank Building Available

    Vacant bank building with drive-thru, previously used as pharmacy.

    616 W Adrian Hwy, Blissfield, MI 49228
    View details
    Retail Space in Brooklyn, MI
    $10 SF/Yr
    1,500 SF

    Retail Space in Brooklyn, MI

    Retail property available for lease in Brooklyn, Michigan.

    145 Wamplers Lake Rd, Brooklyn, MI 49230
    View details
    Updated Office and Retail Space
    $10 SF/Yr
    1,500 SF

    Updated Office and Retail Space

    Prime office and retail space in Columbia Township available for rent.

    145 Wamplers Lk Rd Unit, Brooklyn, MI 49230
    View details

    Explore Similar Spaces for Sale in Adrian, MI

    Consider Similar Space for Sale. We found 28 Spaces in Nearby Locations matching your search parameters.

    West Adrian Professional Office Building
    $525,000
    5,800 SF

    West Adrian Professional Office Building

    Two-level commercial building suitable for medical or office use.

    1542 West Maple Ave, Adrian, MI 49221
    View details
    Commercial/Industrial Property in Adrian, MI
    $129,900
    5,940 SF

    Commercial/Industrial Property in Adrian, MI

    Commercial/Industrial property for sale in Adrian, Michigan.

    401 S Tecumseh St, Adrian, MI 49221
    View details
    Adrian, MI Investment Opportunity
    $333,000
    6,720 SF

    Adrian, MI Investment Opportunity

    Commercial/Industrial property with existing leases and potential income.

    725 W Beecher St, Adrian, MI 49221
    View details
    Corner Commercial Property in Adrian
    Pending
    $295,000
    3,624 SF

    Corner Commercial Property in Adrian

    Commercial property in Adrian, Michigan, suitable for retail or investment.

    4497 N Adrian Hwy, Adrian, MI 49221
    View details
    Versatile Mixed-Use Commercial Space
    $895,000
    16,582 SF

    Versatile Mixed-Use Commercial Space

    Mixed-use property with restaurant, bar, offices, and retail spaces.

    113 E Maumee St, Adrian, MI 49221
    View details
    Former Hospital Redevelopment Opportunity
    $140,000
    23,975 SF

    Former Hospital Redevelopment Opportunity

    Historic building in Adrian, Michigan, suitable for redevelopment.

    120 North Locust St, Adrian, MI 49221
    View details
    Downtown Corner Building with Parking
    $399,900
    16,722 SF

    Downtown Corner Building with Parking

    Two-story commercial building with basement and on-site parking.

    148 S Winter St, Adrian, MI 49221
    View details
    Adrian, MI Dollar Tree Store
    $1,644,068
    19,500 SF

    Adrian, MI Dollar Tree Store

    Single tenant Dollar Tree store with long-term lease.

    408 West Maumee St, Adrian, MI 49221
    View details
    Luxury Multi-Unit Property Near Lake
    $949,900

    Luxury Multi-Unit Property Near Lake

    High-income potential property near Lake Adrian for recreation.

    2550 Bent Oak Ave, Adrian, MI 49221
    View details
    Approved Adult-Use Provisioning Center
    $1,700,000
    4,092 SF

    Approved Adult-Use Provisioning Center

    Municipal approved adult-use provisioning center for sale.

    1032 S Main St, Adrian, MI 49221
    View details

    Adrian, MI Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Adrian, MI with 42 listings featured on our commercial real estate exchange. The current inventory includes 3,404,475,360 square feet of properties with an estimated lease value of $132 SF/Yr.

    Estimated lease rates for Commercial Real Estate in Adrian, MI begin at $4 SF/Yr, with an average of $11 SF/Yr and extend to $20 SF/Yr.

    In Adrian, MI, current lease rates show:

    • Retail properties positioned at $11
    • Individual retail properties measuring $11
    • Office Properties & Spaces assessed at $11
    • Retail space calculated at $11
    List
    Map

    Browse Commercial real estate for Lease Near Adrian, MI

    Popular Searches in Adrian, MI

    Most Searched ZIP Codes in Adrian, MI

    • 49221

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Create New Password
    • At least 8 characters
    • Contains both letters and numbers
    • Contains uppercase and lowercase letters
    • At most 32 characters
    • Password required
    • Password reset link has expired. Please request a new one.