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    Louisville, KY Commercial Real Estate for Lease

    281 results
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    KY, Louisville - East Witherspoon St
    Contact for pricing

    KY, Louisville - East Witherspoon St

    Discover many ways to work your way in KY, Louisville - East Witherspoon St

    222 Witherspoon St, Louisville, KY 40202
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    Retail Building with Drive-Thru
    $12 SF/Yr
    14,500 SF

    Retail Building with Drive-Thru

    701 Valley College Drive, Louisville, KY 40272

    14,500 SF retail building with drive-thru and ample parking.

    • 14,500 SF single‑story retail building with C‑1 zoning allowing diverse commercial uses.
    • Located in a high‑density residential and commercial area with retail, schools, and medical facilities.
    • High traffic location: 1 mile from Stonestreet Rd (ADT 11,960) & Dixie Hwy (ADT 29,531) intersection.
    • 64 parking spaces and one drive‑thru.
    • Across the street from U of L Health Medical Center Southwest and Jefferson Community & Technical College Southwest Campus.
    Updated: Nov 20, 2025
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    St. Matthews Class A Office
    $26 SF/Yr
    12,710 SF

    St. Matthews Class A Office

    4500 Bowling Boulevard, Louisville, KY 40207

    Prime office space in St. Matthews near medical district.

    • Prime "Plug & Play" office space available immediately with furniture included.
    • Unparalleled access to downtown and the East End with convenient access to I‑64 and I‑264.
    • Located in the Dupont Medical District, less than a half mile from three major hospitals.
    • Lowest vacancy rate in the market.
    • Abundant amenities within a mile, including restaurants, hospitality, fitness centers, and shopping.
    Updated: Mar 25
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    Well-Maintained Office Condominium For Rent
    $1,400 /Mo

    Well-Maintained Office Condominium For Rent

    Office condominium with three private offices, reception, and restroom.

    1404 Browns Ln, Louisville, KY 40207
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    Medical Office Freestanding Building
    $18 SF/Yr
    5,300 SF

    Medical Office Freestanding Building

    5,300 SF medical office building for lease in Louisville.

    927 E. Broadway, Louisville, KY 40204
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    KY, Louisville - Linn Station Road
    Contact for pricing

    KY, Louisville - Linn Station Road

    Flexible workspace in KY, Louisville - Linn Station Road

    10200 Linn Station Rd, Louisville, KY 10200
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    Brownsboro Crossing
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    Brownsboro Crossing

    Discover many ways to work your way in Brownsboro Crossing

    9850 Von Allmen Ct, Unit 201, Louisville, KY 40241
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    MET Building
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    MET Building

    Discover many ways to work your way in MET Building

    312 4Th St, Unit 700, Louisville, KY 40202
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    Restaurant Space in Retail Center
    $25 SF/Yr
    3,000 SF

    Restaurant Space in Retail Center

    Restaurant space with existing infrastructure, located in high-traffic area.

    Louisville, KY 40291
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    Updated Office Building For Rent
    $16 SF/Yr
    13,707 SF

    Updated Office Building For Rent

    Two-story office building with professional management and ample parking.

    10180 Linn Station Rd, Louisville, KY 40223
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    Class A Office Building
    $27 SF/Yr
    9,784 SF

    Class A Office Building

    Six-story office building with modern amenities and easy highway access.

    10200 Forest Green Blvd, Louisville, KY 40223
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    Retail Space in Auburndale Center
    $14 SF/Yr

    Retail Space in Auburndale Center

    Retail space with showroom, storage, and high-traffic location.

    7415 3rd Street Road, Louisville, KY 40214
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    Medical Office Space For Rent
    $24 SF/Yr
    2,627 SF

    Medical Office Space For Rent

    Medical office space in high-traffic location near major retailers.

    9370 Cedar Center Way, Louisville, KY 40291
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    Retail Space in High-Traffic Center
    $8 SF/Yr
    27,347 SF

    Retail Space in High-Traffic Center

    Retail space available in a popular Louisville shopping center.

    5518 New Cut Road, Louisville, KY 40214
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    Downtown Louisville Leasing Opportunity
    $12 SF/Yr

    Downtown Louisville Leasing Opportunity

    Prime location with parking, highway access, and modern amenities.

    431 W Oak St, Louisville, KY 40203
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    Freestanding Office/Retail Building For Rent
    $18 SF/Yr
    4,058 SF

    Freestanding Office/Retail Building For Rent

    Office/retail building with monument signage and ample parking available for rent.

    708 Lyndon Ln, Louisville, KY 40222
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    Prime Commercial Space in Fern Creek
    $21 SF/Yr
    4,980 SF

    Prime Commercial Space in Fern Creek

    4980 sqft C1 zoned space available December 2025.

    5700 Bardstown Rd, Louisville, KY
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    Downtown Louisville Warehouse and Showroom
    $5 SF/Yr
    21,710 SF

    Downtown Louisville Warehouse and Showroom

    Warehouse with showroom and office space in downtown Louisville.

    1709-1711 W Main St, Louisville, KY 40203
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    Suburban Office Space For Rent
    $16 SF/Yr
    8,745 SF

    Suburban Office Space For Rent

    Office space in Louisville's premier suburban corridor, ample parking.

    320 Whittington Parkway, Louisville, KY 40222
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    Versatile Flex Space in Louisville
    $6 SF/Yr
    17,479 SF

    Versatile Flex Space in Louisville

    Mix of office, shop, and open areas with crane.

    1900 W Muhammad Ali Blvd, Louisville, KY 40203
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    Class A Office Building Space
    $23 SF/Yr
    11,457 SF

    Class A Office Building Space

    Class A office building with vacancies in Eastpoint area.

    1700 Eastpoint Parkway, Louisville, KY 40223
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    Renovated Office Space For Rent
    $19 SF/Yr
    7,460 SF

    Renovated Office Space For Rent

    7,460 SF office space near 4th Street Live!

    501 South 2nd Street, Louisville, KY 40202
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    Suburban Office Space Available
    $16 SF/Yr
    4,856 SF

    Suburban Office Space Available

    Conveniently located office space in Louisville's premier suburban corridor.

    9110 Leesgate Road, Louisville, KY 40222
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    Retail Space in High-Traffic Area
    $24 SF/Yr
    1,600 SF

    Retail Space in High-Traffic Area

    Retail space with high visibility near major retailers and healthcare.

    9314 Cedar Center Way, Louisville, KY 40291
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    Louisville, KY Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Louisville, KY with 281 listings featured on our commercial real estate exchange. The current inventory includes 59,857,538,400 square feet of properties with an estimated lease value of $561 /Mo.

    Estimated lease rates for Commercial real estate in Louisville, KY begin at $5 SF/Yr, with an average of $14 SF/Yr and extend to $27 SF/Yr.
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    Browse Commercial real estate for Lease Near Louisville, KY

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    Most Searched ZIP Codes in Louisville, KY

    • 40299
    • 40223
    • 40202
    • 40214
    • 40258
    • 40219
    • 40220
    • 40222
    • 40203
    • 40241
    • 40245

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