St Francois County, MO Storefront properties for sale

$850,000

15,500 SF

De Soto Retail Business Opportunity

400 S Main St, De Soto, MO 63020

Own a business and a piece of history!

Established, family‑owned business with included inventory and seller assistance during transition.
Dual storefronts offer the opportunity to operate a business while renting out the other side for additional income.
Large main office, great prep space, and an open upper level with unique features like a glass floor and lift elevator.
Recent maintenance includes roof work, updated electric, and HVAC improvements.
Historic brick building built in 1870.

Updated: Dec 17, 2025

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Versatile Commercial Property on Highway 67

$1,399,000

15,000 SF

Versatile Commercial Property on Highway 67

3350 Highway O, Park Hills, MO 63601

Commercial property with high-traffic location, multiple buildings, and income streams.

Nearly 1,000 feet of prime road frontage on Highway 67 with high visibility and accessibility.
15,000 square feet of flexible space suitable for various commercial purposes (church, restaurant, office, etc.).
Existing income streams from billboard ($2,400/year) and cell tower ($7,200/year).
44 self‑storage units available to rent for additional income (potential of $3500/month).
Strategic location directly across from Mineral Area College, ensuring high traffic.

Updated: Dec 27, 2025

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Based on your search, we've compiled 3 Potential Opportunities for your consideration. Besides 2 Active listings in St Francois County, MO, we suggest exploring several alternatives: plus 1 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Pending

$160,000

5,210 SF

Bonne Terre Mixed-Use Property

Income-producing mixed-use property with development potential in Bonne Terre.

32 W School St, Bonne Terre, MO 63628

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St Francois County, MO Storefront Properties Investment Opportunities Market Analysis

Explore 2 storefront properties for sale in St Francois County, MO on our real estate platform. These investment opportunities span a total of 304,920 square feet of properties for sale, with an estimated market value of $2,249,000.

Prices for retail units in St Francois County, MO start at $850,000, averaging $1,124,500, and reaching up to $1,399,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

St Francois County, MO Storefront Properties for Sale

De Soto Retail Business Opportunity

Own a business and a piece of history!

Versatile Commercial Property on Highway 67

Commercial property with high-traffic location, multiple buildings, and income streams.

Potential Development Sites for Consideration

Bonne Terre Mixed-Use Property

St Francois County, MO Storefront Properties Investment Opportunities Market Analysis

Browse Storefront properties for Sale Near St Francois, MO

St Francois County, MO Storefront Properties for Sale

De Soto Retail Business Opportunity

Own a business and a piece of history!

Versatile Commercial Property on Highway 67

Commercial property with high-traffic location, multiple buildings, and income streams.

Potential Development Sites for Consideration

Bonne Terre Mixed-Use Property

St Francois County, MO Storefront Properties Investment Opportunities Market Analysis

Browse Storefront properties for Sale Near St Francois, MO

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