Chicago, IL Medical space for Rent & Lease

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West Town Storefront with Clinical Build-Out

1638 W Chicago Ave, Chicago, IL 60622

B1-2 zoned storefront with clinical infrastructure in West Town.

Rare B1‑2 zoning allows for a wide range of commercial uses.
Clinical infrastructure already in place, including 2 wet rooms with plumbing and a private shower.
Recently updated dual‑zone HVAC system.
Located in the high‑traffic West Town/Ukrainian Village commercial corridor.
Eligible for West Town SSA #29 rebates for signage, security, and facade improvements.

Updated: Dec 10, 2025

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$25 SF/Yr

High-Traffic Retail/Office/Medical Space Available

1325 W Wilson Ave, Chicago, IL 60640

Renovated space suitable for retail, office, or medical use.

High traffic location on Wilson Avenue.
Suitable for diverse uses: retail, office, medical, personal service.
Located in a building with 121 renovated apartment units.
Close to Harry S Truman College.
Near CTA Red and Purple Lines (Wilson Station).

Updated: Jul 15, 2025

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$35 SF/Yr

River North Multi-Use Space

Versatile space in River North, suitable for office, retail, or medical.

16 W Ontario St, Chicago, IL 60654

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$35 SF/Yr

River North Versatile Space For Rent

Multi-room space in River North suitable for various businesses.

16 W Ontario St, Chicago, IL 60654

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$117 SF/Yr

Milwaukee Avenue Private Suite

Private suite ideal for licensed professionals in Logan Square.

2839 N Milwaukee Ave, Chicago, IL 60618

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$41 SF/Yr

Turnkey Medical Office in Gold Coast

4,400 SF medical office space for lease in Chicago's Gold Coast.

33 W Delaware Pl, Chicago, IL 60610

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$12 SF/Yr

12,000 SF

Prime Retail Space, South Shore

12,000 SF, High-Visibility Location

2015 79Th St, Chicago, IL 60649

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1,915 SF

Printer's Row Retail Space Available

1915 sq ft Retail Space - Prime Location

642 Clark St, Chicago, IL 60605

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$70 SF/Yr

Millennium Station Retail/Office/Medical Space

Storefront retail, office, or medical spaces in Millennium Station.

151 N Michigan Ave, Chicago, IL 60602

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$35 SF/Yr

Prime Retail Space on Belmont

High-traffic retail space with excellent street exposure and flexible usage.

906 W Belmont Ave, Chicago, IL 60657

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$30 SF/Yr

New Retail Spaces on Lincoln

New construction retail/office/medical spaces in North Center near public transit.

3914 N Lincoln Ave, Chicago, IL 60613

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$20 SF/Yr

Available Storefronts North of Irving

Three storefronts available for lease in a local business corridor.

4075 N Broadway St, Chicago, IL 60613

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$24 SF/Yr

Renovated Gold Coast Retail/Office Space

Recently renovated retail or office space in Gold Coast location.

1221 N La Salle St, Chicago, IL 60610

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$12 SF/Yr

West Town/Kinzie Corridor Office Space

Economical office and lab spaces available for lease.

2450 W Hubbard St, Chicago, IL 60612

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$21 SF/Yr

Division Street Commercial Condo for Lease

Ground-floor commercial condo in Old Town, ideal for various uses.

511 W Division St, Chicago, IL 60610

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$27 SF/Yr

1,290 SF

Turnkey Retail/Office Space Available

1,290 SF retail/office space in a high-visibility location.

2040 W Belmont Ave, Chicago, IL 60657

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160,008 SF

Retail Space Near Loyola Campus

Storefront in a 152-unit building near Loyola University.

6466 N Sheridan Rd, Chicago, IL 60626

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1,836 SF

Medical and Spa Space Available

Second-generation medical and spa spaces in a high-traffic location.

730 N La Salle Dr, Chicago, IL 60654

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$28 SF/Yr

5,838 SF

Retail Space Near Loyola Campus

Retail space near Loyola's Rogers Park campus, high visibility.

6418-6438 N Sheridan Rd, Chicago, IL 60613

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900 SF

Medical/Retail Space Near Rush Hospital

Located in Illinois Medical District near hospitals and transportation.

1438-1550 W Harrison St, Chicago, IL 60607

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Streeterville Retail/Office/Medical Space Available

$20 SF/Yr

4,042 SF

Streeterville Retail/Office/Medical Space Available

Move-in ready space adaptable for salon, spa, medical, or office.

200 E Delaware Pl, Chicago, IL 60611

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$27 SF/Yr

2,464 SF

Retail Space Near Loyola Campus

Retail, restaurant, or medical space near Loyola University campus.

1209-6470 W Arthur Ave, Chicago, IL 60626

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Retail/Healthcare Space Near Pulaski Road

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3,174 SF

Retail/Healthcare Space Near Pulaski Road

3,174 SF retail/healthcare space with convenient access and parking.

11500 S Pulaski Rd, Alsip, IL 60803

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Roseland Healthcare Facility Opportunity

Pending

$229,900

1,926 SF

Roseland Healthcare Facility Opportunity

Turnkey medical/dental clinic, pharmacy, or daycare opportunity in Chicago.

1 E 111Th St, Chicago, IL 60628

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Chicago, IL Medical space Leasing Opportunities Market Analysis

Explore Medical space leasing options in Chicago, IL with 29 listings featured on our commercial real estate exchange. The current inventory includes 1,116,617,040 square feet of properties with an estimated lease value of $114 SF/Yr.

Estimated lease rates for Medical space in Chicago, IL begin at $12 SF/Yr, with an average of $22 SF/Yr and extend to $28 SF/Yr.

Chicago, IL Medical Space for Lease

West Town Storefront with Clinical Build-Out

B1-2 zoned storefront with clinical infrastructure in West Town.